======= PAN3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PAN3
  * **<color #00a2e8>Official Name</color>**: poly(A) specific ribonuclease subunit PAN3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=255967|255967]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q58A45|Q58A45]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PAN3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PAN3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617448|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|PAN complex|
|positive regulation of cytoplasmic mRNA processing body assembly|
|regulation of cytoplasmic mRNA processing body assembly|
|deadenylation-dependent decapping of nuclear-transcribed mRNA|
|poly(A)-specific ribonuclease activity|
|nuclear-transcribed mRNA poly(A) tail shortening|
|RNA phosphodiester bond hydrolysis, exonucleolytic|
|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|positive regulation of organelle assembly|
|P-body|
|RNA phosphodiester bond hydrolysis|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|regulation of organelle assembly|
|protein kinase activity|
|RNA catabolic process|
|positive regulation of protein complex assembly|
|nucleic acid phosphodiester bond hydrolysis|
|protein targeting|
|nucleobase-containing compound catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|regulation of protein complex assembly|
|mRNA processing|
|organic cyclic compound catabolic process|
|positive regulation of cellular component biogenesis|
|positive regulation of organelle organization|
|mRNA metabolic process|
|RNA processing|
|cellular macromolecule catabolic process|
|regulation of cellular component biogenesis|
|protein phosphorylation|
|intracellular protein transport|
|macromolecule catabolic process|
|positive regulation of cellular component organization|
|phosphorylation|
|regulation of organelle organization|
|RNA binding|
|ATP binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|RNA metabolic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp135|MS023 7μM R03 exp135]]|-1.83|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.81|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-1.79|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.76|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|-1.73|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.72|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|1.71|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.91|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.95|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pan2|PAN2]]|0.672|
|[[:human genes:v:vasn|VASN]]|0.598|
|[[:human genes:r:rrm1|RRM1]]|0.577|
|[[:human genes:c:chd4|CHD4]]|0.57|
|[[:human genes:s:smg7|SMG7]]|0.55|
|[[:human genes:d:dtl|DTL]]|0.549|
|[[:human genes:p:psmd11|PSMD11]]|0.548|
|[[:human genes:z:zfand5|ZFAND5]]|0.541|
|[[:human genes:p:psmc1|PSMC1]]|0.536|
|[[:human genes:p:psmd1|PSMD1]]|0.534|
|[[:human genes:k:kctd17|KCTD17]]|0.531|
|[[:human genes:s:supt6h|SUPT6H]]|0.529|
|[[:human genes:n:narfl|NARFL]]|0.528|
|[[:human genes:p:psmd3|PSMD3]]|0.526|
|[[:human genes:m:mt1e|MT1E]]|0.524|
|[[:human genes:c:copg1|COPG1]]|0.523|
|[[:human genes:p:pole|POLE]]|0.519|
|[[:human genes:k:kpnb1|KPNB1]]|0.517|
|[[:human genes:p:paf1|PAF1]]|0.516|
|[[:human genes:s:smg1|SMG1]]|0.514|
|[[:human genes:r:rpl35|RPL35]]|0.512|
|[[:human genes:p:psmc3|PSMC3]]|0.511|
|[[:human genes:p:psmb4|PSMB4]]|0.507|
|[[:human genes:o:orc1|ORC1]]|0.504|
|[[:human genes:r:rad21|RAD21]]|0.502|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.502|
|[[:human genes:c:copb1|COPB1]]|0.501|
|[[:human genes:a:ankle2|ANKLE2]]|0.5|
|[[:human genes:d:disp2|DISP2]]|0.498|
|[[:human genes:i:igfn1|IGFN1]]|0.497|
|[[:human genes:i:ik|IK]]|0.492|
|[[:human genes:n:nop16|NOP16]]|0.489|
|[[:human genes:s:supt5h|SUPT5H]]|0.489|
|[[:human genes:n:nup205|NUP205]]|0.488|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.487|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.487|
|[[:human genes:e:exosc9|EXOSC9]]|0.487|
|[[:human genes:t:tceb3c|TCEB3C]]|0.485|
|[[:human genes:l:lrr1|LRR1]]|0.484|
|[[:human genes:a:aamp|AAMP]]|0.484|
|[[:human genes:c:cdca3|CDCA3]]|0.483|
|[[:human genes:z:znf830|ZNF830]]|0.483|
|[[:human genes:s:sap30bp|SAP30BP]]|0.481|
|[[:human genes:c:copa|COPA]]|0.48|
|[[:human genes:c:c14orf93|C14orf93]]|0.48|
|[[:human genes:c:ccna2|CCNA2]]|0.478|
|[[:human genes:p:psmd14|PSMD14]]|0.478|
|[[:human genes:b:brd2|BRD2]]|0.477|
|[[:human genes:t:tsg101|TSG101]]|0.477|
|[[:human genes:d:dnm2|DNM2]]|0.476|
|[[:human genes:p:psmc6|PSMC6]]|0.475|
|[[:human genes:p:psmc2|PSMC2]]|0.474|
|[[:human genes:s:sfpq|SFPQ]]|0.474|
|[[:human genes:a:arcn1|ARCN1]]|0.473|
|[[:human genes:a:atxn1|ATXN1]]|0.472|
|[[:human genes:u:upf1|UPF1]]|0.472|
|[[:human genes:c:ctr9|CTR9]]|0.471|
|[[:human genes:c:copb2|COPB2]]|0.47|
|[[:human genes:e:exosc3|EXOSC3]]|0.469|
|[[:human genes:c:cbwd3|CBWD3]]|0.468|
|[[:human genes:n:nol10|NOL10]]|0.467|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.466|
|[[:human genes:c:col2a1|COL2A1]]|0.466|
|[[:human genes:t:ticrr|TICRR]]|0.466|
|[[:human genes:a:atp13a1|ATP13A1]]|0.466|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.465|
|[[:human genes:r:rps19|RPS19]]|0.464|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.464|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.464|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.463|
|[[:human genes:d:ddtl|DDTL]]|0.463|
|[[:human genes:s:scaf1|SCAF1]]|0.462|
|[[:human genes:r:rps9|RPS9]]|0.461|
|[[:human genes:r:ranbp2|RANBP2]]|0.461|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.46|
|[[:human genes:n:npipb5|NPIPB5]]|0.459|
|[[:human genes:p:pola1|POLA1]]|0.457|
|[[:human genes:o:orc6|ORC6]]|0.457|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.456|
|[[:human genes:s:sf3a1|SF3A1]]|0.455|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.454|
|[[:human genes:c:cdc73|CDC73]]|0.454|
|[[:human genes:n:nup160|NUP160]]|0.454|
|[[:human genes:t:terf2|TERF2]]|0.452|
|[[:human genes:h:hist2h3d|HIST2H3D]]|0.45|
|[[:human genes:n:nupl1|NUPL1]]|0.45|
|[[:human genes:p:prim1|PRIM1]]|0.45|
|[[:human genes:c:chaf1a|CHAF1A]]|0.45|
|[[:human genes:c:cope|COPE]]|0.449|
|[[:human genes:t:terf1|TERF1]]|0.448|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.447|
|[[:human genes:s:sf3a3|SF3A3]]|0.447|
|[[:human genes:k:krt2|KRT2]]|0.447|
|[[:human genes:p:pola2|POLA2]]|0.445|
|[[:human genes:g:golga8o|GOLGA8O]]|0.445|
|[[:human genes:d:dock6|DOCK6]]|0.444|
|[[:human genes:p:pcf11|PCF11]]|0.444|
|[[:human genes:u:uqcrh|UQCRH]]|0.443|
|[[:human genes:s:slc4a1|SLC4A1]]|0.442|
|[[:human genes:x:xylt2|XYLT2]]|0.442|
|[[:human genes:r:rad51|RAD51]]|0.442|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.441|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.441|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.441|
|[[:human genes:g:gid4|GID4]]|0.441|
|[[:human genes:a:aqr|AQR]]|0.441|
|[[:human genes:t:traip|TRAIP]]|0.441|
|[[:human genes:s:sart1|SART1]]|0.441|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.44|
|[[:human genes:r:rbm39|RBM39]]|0.439|
|[[:human genes:p:psmb2|PSMB2]]|0.439|
|[[:human genes:t:twistnb|TWISTNB]]|0.439|
|[[:human genes:s:snip1|SNIP1]]|0.438|
|[[:human genes:s:snrpa1|SNRPA1]]|0.438|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.438|
|[[:human genes:p:psma6|PSMA6]]|0.438|
|[[:human genes:d:dhx38|DHX38]]|0.437|
|[[:human genes:c:ctage9|CTAGE9]]|0.437|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.436|
|[[:human genes:p:polr2d|POLR2D]]|0.436|
|[[:human genes:c:cbwd6|CBWD6]]|0.435|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.435|
|[[:human genes:d:ddx56|DDX56]]|0.435|
|[[:human genes:c:cbwd5|CBWD5]]|0.435|
|[[:human genes:g:gprin2|GPRIN2]]|0.434|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.433|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.433|
|[[:human genes:u:utp3|UTP3]]|0.433|
|[[:human genes:z:znf106|ZNF106]]|0.43|
|[[:human genes:c:cgb2|CGB2]]|0.43|
|[[:human genes:m:med17|MED17]]|0.429|
|[[:human genes:p:pwp2|PWP2]]|0.429|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.429|
|[[:human genes:p:ppm1d|PPM1D]]|0.429|
|[[:human genes:v:vps28|VPS28]]|0.429|
|[[:human genes:t:tyms|TYMS]]|0.428|
|[[:human genes:r:rplp1|RPLP1]]|0.427|
|[[:human genes:s:slc6a17|SLC6A17]]|0.427|
|[[:human genes:s:sf3b3|SF3B3]]|0.426|
|[[:human genes:l:lad1|LAD1]]|0.425|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.425|
|[[:human genes:g:golga8j|GOLGA8J]]|0.424|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.423|
|[[:human genes:t:taf1|TAF1]]|0.423|
|[[:human genes:t:timeless|TIMELESS]]|0.423|
|[[:human genes:t:tagln|TAGLN]]|0.422|
|[[:human genes:e:ell|ELL]]|0.422|
|[[:human genes:c:clcn6|CLCN6]]|0.422|
|[[:human genes:s:ssh2|SSH2]]|0.422|
|[[:human genes:g:gar1|GAR1]]|0.421|
|[[:human genes:c:cdca5|CDCA5]]|0.421|
|[[:human genes:m:myo1h|MYO1H]]|0.421|
|[[:human genes:h:hist1h4b|HIST1H4B]]|0.42|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.42|
|[[:human genes:z:znf655|ZNF655]]|0.42|
|[[:human genes:w:wdr43|WDR43]]|0.419|
|[[:human genes:r:rpa2|RPA2]]|0.418|
|[[:human genes:p:psmd2|PSMD2]]|0.418|
|[[:human genes:r:rpl30|RPL30]]|0.418|
|[[:human genes:a:adrm1|ADRM1]]|0.418|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.418|
|[[:human genes:c:cep192|CEP192]]|0.417|
|[[:human genes:c:ctage4|CTAGE4]]|0.417|
|[[:human genes:s:sec13|SEC13]]|0.417|
|[[:human genes:p:plk1|PLK1]]|0.416|
|[[:human genes:p:psmd8|PSMD8]]|0.415|
|[[:human genes:p:parp3|PARP3]]|0.415|
|[[:human genes:o:osbp|OSBP]]|0.415|
|[[:human genes:d:ddt|DDT]]|0.415|
|[[:human genes:c:copz1|COPZ1]]|0.415|
|[[:human genes:m:mfsd12|MFSD12]]|0.414|
|[[:human genes:h:hap1|HAP1]]|0.414|
|[[:human genes:m:mylk3|MYLK3]]|0.414|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.414|
|[[:human genes:p:psmc4|PSMC4]]|0.412|
|[[:human genes:c:cln6|CLN6]]|0.412|
|[[:human genes:m:myh7b|MYH7B]]|0.412|
|[[:human genes:r:rps2|RPS2]]|0.411|
|[[:human genes:c:cdt1|CDT1]]|0.411|
|[[:human genes:h:hivep3|HIVEP3]]|0.411|
|[[:human genes:p:psmb1|PSMB1]]|0.41|
|[[:human genes:r:rnpc3|RNPC3]]|0.41|
|[[:human genes:v:vps54|VPS54]]|0.41|
|[[:human genes:d:ddx21|DDX21]]|0.41|
|[[:human genes:k:krt78|KRT78]]|0.409|
|[[:human genes:p:pigs|PIGS]]|0.408|
|[[:human genes:e:eif4a3|EIF4A3]]|0.406|
|[[:human genes:p:prkcz|PRKCZ]]|0.406|
|[[:human genes:r:rpl6|RPL6]]|0.405|
|[[:human genes:p:polr2f|POLR2F]]|0.405|
|[[:human genes:c:clptm1|CLPTM1]]|0.404|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.403|
|[[:human genes:p:polr2j3|POLR2J3]]|0.402|
|[[:human genes:k:kif3c|KIF3C]]|0.401|
|[[:human genes:n:nup85|NUP85]]|0.401|
|[[:human genes:i:iscu|ISCU]]|0.401|
|[[:human genes:e:exosc5|EXOSC5]]|0.4|
|[[:human genes:a:acsf2|ACSF2]]|0.4|
|[[:human genes:m:med14|MED14]]|0.4|
|[[:human genes:a:ankle1|ANKLE1]]|0.4|
|[[:human genes:c:ccdc116|CCDC116]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1888
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PAN3 Expression in NALM6 Cells: 6.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>