======= PARD3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PARD3
  * **<color #00a2e8>Official Name</color>**: par-3 family cell polarity regulator
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56288|56288]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TEW0|Q8TEW0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PARD3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PARD3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606745|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3534|
|PDZ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|internode region of axon|
|establishment of centrosome localization|
|asymmetric cell division|
|positive regulation of myelination|
|negative regulation of peptidyl-threonine phosphorylation|
|apical junction complex|
|peripheral nervous system axon ensheathment|
|myelination in peripheral nervous system|
|axonal growth cone|
|protein kinase C-activating G protein-coupled receptor signaling pathway|
|Schwann cell development|
|centrosome localization|
|microtubule organizing center localization|
|establishment of epithelial cell polarity|
|Schwann cell differentiation|
|bicellular tight junction assembly|
|tight junction assembly|
|tight junction organization|
|phosphatidylinositol-3,4,5-trisphosphate binding|
|phosphatidylinositol-3-phosphate binding|
|regulation of myelination|
|regulation of peptidyl-threonine phosphorylation|
|apical junction assembly|
|establishment or maintenance of epithelial cell apical/basal polarity|
|establishment or maintenance of apical/basal cell polarity|
|establishment or maintenance of bipolar cell polarity|
|positive regulation of nervous system process|
|adherens junction|
|peripheral nervous system development|
|endomembrane system|
|phosphatidylinositol-4,5-bisphosphate binding|
|protein phosphatase binding|
|phosphatidylinositol binding|
|transforming growth factor beta receptor signaling pathway|
|cell-cell junction assembly|
|cell-cell adherens junction|
|myelination|
|glial cell development|
|ensheathment of neurons|
|axon ensheathment|
|establishment of cell polarity|
|bicellular tight junction|
|cell cortex|
|regulation of nervous system process|
|cell-cell junction organization|
|cellular response to transforming growth factor beta stimulus|
|protein targeting to membrane|
|response to transforming growth factor beta|
|cell junction assembly|
|glial cell differentiation|
|cell-cell junction|
|establishment or maintenance of cell polarity|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|cell junction organization|
|gliogenesis|
|establishment of protein localization to membrane|
|apical plasma membrane|
|protein targeting|
|establishment of organelle localization|
|cytoskeleton|
|axonogenesis|
|neuronal cell body|
|negative regulation of protein phosphorylation|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|negative regulation of phosphorylation|
|microtubule cytoskeleton organization|
|protein localization to membrane|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell division|
|cellular response to growth factor stimulus|
|cell part morphogenesis|
|response to growth factor|
|positive regulation of nervous system development|
|cell junction|
|cell morphogenesis involved in differentiation|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|organelle localization|
|regulation of system process|
|negative regulation of protein modification process|
|protein-containing complex|
|neuron projection development|
|microtubule-based process|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|regulation of cellular localization|
|regulation of nervous system development|
|cell adhesion|
|biological adhesion|
|intracellular protein transport|
|neuron differentiation|
|negative regulation of cellular protein metabolic process|
|identical protein binding|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|cellular response to endogenous stimulus|
|G protein-coupled receptor signaling pathway|
|cell cycle|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp115|A-366 10μM R03 exp115]]|-1.76|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.71|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.72|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|1.89|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|2.16|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4055
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PARD3 Expression in NALM6 Cells: 5.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>