======= PARL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PARL
  * **<color #00a2e8>Official Name</color>**: presenilin associated rhomboid like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55486|55486]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H300|Q9H300]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PARL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PARL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607858|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the rhomboid family of intramembrane serine proteases that is localized to the inner mitochondrial membrane. The encoded protein regulates mitochondrial remodeling and apoptosis through regulated substrate proteolysis. Proteolytic processing of the encoded protein results in the release of a small peptide, P-beta, which may transit to the nucleus. Mutations in this gene may be associated with Parkinson's disease. [provided by RefSeq, May 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain. {ECO:0000250, ECO:0000269|PubMed:14732705, ECO:0000269|PubMed:17116872}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rhomboid|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial calcium ion transmembrane transport|
|membrane protein proteolysis|
|regulation of protein targeting to mitochondrion|
|regulation of establishment of protein localization to mitochondrion|
|endopeptidase activity|
|regulation of protein targeting|
|serine-type endopeptidase activity|
|regulation of reactive oxygen species metabolic process|
|regulation of mitochondrion organization|
|calcium ion transmembrane transport|
|regulation of intracellular protein transport|
|calcium ion transport|
|divalent metal ion transport|
|divalent inorganic cation transport|
|regulation of intracellular transport|
|mitochondrial inner membrane|
|regulation of cellular protein localization|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|regulation of protein transport|
|regulation of proteolysis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|cation transport|
|regulation of cellular localization|
|ion transmembrane transport|
|regulation of protein localization|
|mitochondrion|
|proteolysis|
|transmembrane transport|
|regulation of organelle organization|
|ion transport|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-4.71|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-3.01|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.62|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-2.41|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-2.18|
|[[:results:exp16|DABN 2μM R00 exp16]]|-2.15|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-2.03|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|-2|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-1.95|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|-1.92|
|[[:results:exp495|IWR1 50μM R08 exp495]]|-1.81|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.71|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.71|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.77|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|1.82|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.82|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.83|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.88|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.92|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.94|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.95|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.96|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.99|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|2.12|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.17|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2.22|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.49|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.55|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.56|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:crls1|CRLS1]]|0.537|
|[[:human genes:r:romo1|ROMO1]]|0.507|
|[[:human genes:t:triap1|TRIAP1]]|0.47|
|[[:human genes:t:taz|TAZ]]|0.451|
|[[:human genes:t:timm8a|TIMM8A]]|0.433|
|[[:human genes:t:trmt10a|TRMT10A]]|0.431|
|[[:human genes:s:sec62|SEC62]]|0.424|
|[[:human genes:t:timm8b|TIMM8B]]|0.416|
|[[:human genes:c:clpb|CLPB]]|0.416|
|[[:human genes:s:ssbp2|SSBP2]]|0.406|
|[[:human genes:s:sox7|SOX7]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11903
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PARL Expression in NALM6 Cells: 5.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>