======= PARP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PARP2
  * **<color #00a2e8>Official Name</color>**: poly(ADP-ribose) polymerase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10038|10038]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UGN5|Q9UGN5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PARP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PARP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607725|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism (PubMed:10364231, PubMed:28190768). This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:10364231). Mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity (PubMed:28190768). {ECO:0000269|PubMed:10364231, ECO:0000269|PubMed:28190768}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PARP|
|PARP reg|
|WGR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NAD DNA ADP-ribosyltransferase activity|
|DNA ADP-ribosylation|
|peptidyl-serine ADP-ribosylation|
|positive regulation of cell growth involved in cardiac muscle cell development|
|protein poly-ADP-ribosylation|
|protein ADP-ribosylase activity|
|regulation of cell growth involved in cardiac muscle cell development|
|positive regulation of cardiac muscle cell differentiation|
|NAD+ ADP-ribosyltransferase activity|
|positive regulation of cardiocyte differentiation|
|positive regulation of cardiac muscle hypertrophy|
|protein ADP-ribosylation|
|positive regulation of muscle hypertrophy|
|positive regulation of cardiac muscle tissue growth|
|regulation of cardiac muscle cell differentiation|
|positive regulation of heart growth|
|base-excision repair|
|positive regulation of cardiac muscle tissue development|
|positive regulation of organ growth|
|regulation of cardiocyte differentiation|
|regulation of cardiac muscle hypertrophy|
|positive regulation of striated muscle cell differentiation|
|regulation of cardiac muscle tissue growth|
|regulation of muscle hypertrophy|
|regulation of heart growth|
|positive regulation of muscle organ development|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle tissue development|
|regulation of cardiac muscle tissue development|
|regulation of muscle adaptation|
|positive regulation of muscle cell differentiation|
|DNA modification|
|regulation of organ growth|
|extrinsic apoptotic signaling pathway|
|regulation of striated muscle cell differentiation|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|regulation of muscle cell differentiation|
|positive regulation of cell growth|
|positive regulation of developmental growth|
|double-strand break repair|
|peptidyl-serine modification|
|negative regulation of neuron death|
|regulation of muscle system process|
|positive regulation of growth|
|apoptotic signaling pathway|
|regulation of neuron death|
|regulation of developmental growth|
|regulation of cell growth|
|DNA repair|
|positive regulation of cell development|
|regulation of system process|
|regulation of growth|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|nucleolus|
|peptidyl-amino acid modification|
|apoptotic process|
|regulation of cell development|
|positive regulation of cell differentiation|
|negative regulation of cell death|
|programmed cell death|
|cell death|
|positive regulation of developmental process|
|DNA binding|
|regulation of cell death|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.7|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|1.82|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|2.21|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|2.4|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|2.74|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|2.83|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|4.53|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18478
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PARP2 Expression in NALM6 Cells: 6.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>