======= PARS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PARS2
  * **<color #00a2e8>Official Name</color>**: prolyl-tRNA synthetase 2, mitochondrial
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25973|25973]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7L3T8|Q7L3T8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PARS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PARS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612036|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of proline to tRNA molecules. Mutations have been found in this gene in some patients with Alpers syndrome. [provided by RefSeq, Mar 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|tRNA-synt 2b|
|HGTP anticodon|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|proline-tRNA ligase activity|
|prolyl-tRNA aminoacylation|
|tRNA aminoacylation for protein translation|
|tRNA aminoacylation|
|amino acid activation|
|tRNA metabolic process|
|cellular amino acid metabolic process|
|mitochondrial matrix|
|translation|
|peptide biosynthetic process|
|ncRNA metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp124|GSK343 3μM R03 exp124]]|-1.76|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-1.75|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.76|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.8|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.86|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.86|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.87|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.9|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.95|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.97|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.98|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.02|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.15|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.31|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hsd17b10|HSD17B10]]|0.744|
|[[:human genes:t:tars2|TARS2]]|0.738|
|[[:human genes:y:yars2|YARS2]]|0.735|
|[[:human genes:d:dap3|DAP3]]|0.725|
|[[:human genes:n:nars2|NARS2]]|0.722|
|[[:human genes:s:selrc1|SELRC1]]|0.714|
|[[:human genes:m:mrps6|MRPS6]]|0.711|
|[[:human genes:m:mrpl23|MRPL23]]|0.709|
|[[:human genes:l:lars2|LARS2]]|0.691|
|[[:human genes:m:mrpl21|MRPL21]]|0.676|
|[[:human genes:e:ears2|EARS2]]|0.674|
|[[:human genes:q:qrsl1|QRSL1]]|0.666|
|[[:human genes:s:sco2|SCO2]]|0.665|
|[[:human genes:m:mrps34|MRPS34]]|0.662|
|[[:human genes:m:mrps21|MRPS21]]|0.658|
|[[:human genes:m:mrps16|MRPS16]]|0.657|
|[[:human genes:g:gfm1|GFM1]]|0.657|
|[[:human genes:v:vars2|VARS2]]|0.654|
|[[:human genes:r:rpusd4|RPUSD4]]|0.649|
|[[:human genes:r:rars2|RARS2]]|0.649|
|[[:human genes:h:hars2|HARS2]]|0.647|
|[[:human genes:m:mrps14|MRPS14]]|0.641|
|[[:human genes:d:dars2|DARS2]]|0.639|
|[[:human genes:w:wbscr16|WBSCR16]]|0.634|
|[[:human genes:g:gatc|GATC]]|0.63|
|[[:human genes:m:mrps25|MRPS25]]|0.628|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.626|
|[[:human genes:m:mtg2|MTG2]]|0.623|
|[[:human genes:m:mars2|MARS2]]|0.621|
|[[:human genes:f:fastkd5|FASTKD5]]|0.621|
|[[:human genes:c:c10orf2|C10orf2]]|0.62|
|[[:human genes:m:mrps5|MRPS5]]|0.619|
|[[:human genes:n:ndufb11|NDUFB11]]|0.616|
|[[:human genes:a:aars2|AARS2]]|0.615|
|[[:human genes:m:mrp63|MRP63]]|0.611|
|[[:human genes:m:mrps26|MRPS26]]|0.611|
|[[:human genes:p:pet112|PET112]]|0.609|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.609|
|[[:human genes:m:mrpl47|MRPL47]]|0.606|
|[[:human genes:f:ftsj2|FTSJ2]]|0.604|
|[[:human genes:m:mrpl3|MRPL3]]|0.603|
|[[:human genes:c:cox16|COX16]]|0.6|
|[[:human genes:r:rbfa|RBFA]]|0.599|
|[[:human genes:b:bcs1l|BCS1L]]|0.599|
|[[:human genes:m:mettl17|METTL17]]|0.599|
|[[:human genes:m:mrps10|MRPS10]]|0.597|
|[[:human genes:m:mrpl53|MRPL53]]|0.596|
|[[:human genes:g:gfm2|GFM2]]|0.592|
|[[:human genes:c:coa3|COA3]]|0.592|
|[[:human genes:p:polrmt|POLRMT]]|0.592|
|[[:human genes:p:polg2|POLG2]]|0.591|
|[[:human genes:m:mrps2|MRPS2]]|0.591|
|[[:human genes:s:sars2|SARS2]]|0.585|
|[[:human genes:d:dnlz|DNLZ]]|0.58|
|[[:human genes:m:mrpl12|MRPL12]]|0.578|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.573|
|[[:human genes:p:polg|POLG]]|0.57|
|[[:human genes:m:mrpl20|MRPL20]]|0.57|
|[[:human genes:c:cox11|COX11]]|0.568|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.564|
|[[:human genes:m:mrps18a|MRPS18A]]|0.563|
|[[:human genes:m:mrps24|MRPS24]]|0.561|
|[[:human genes:c:coa6|COA6]]|0.56|
|[[:human genes:n:ndufa3|NDUFA3]]|0.558|
|[[:human genes:p:pet117|PET117]]|0.557|
|[[:human genes:p:pgm3|PGM3]]|0.556|
|[[:human genes:m:mrps12|MRPS12]]|0.555|
|[[:human genes:r:rpusd3|RPUSD3]]|0.553|
|[[:human genes:m:mrps9|MRPS9]]|0.551|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.551|
|[[:human genes:w:wars2|WARS2]]|0.548|
|[[:human genes:m:mrps35|MRPS35]]|0.547|
|[[:human genes:f:fars2|FARS2]]|0.545|
|[[:human genes:m:mrpl45|MRPL45]]|0.545|
|[[:human genes:m:mrpl15|MRPL15]]|0.542|
|[[:human genes:t:tefm|TEFM]]|0.542|
|[[:human genes:m:mrps33|MRPS33]]|0.54|
|[[:human genes:m:mrpl4|MRPL4]]|0.539|
|[[:human genes:a:atp5d|ATP5D]]|0.539|
|[[:human genes:m:mrpl42|MRPL42]]|0.538|
|[[:human genes:d:dhrsx|DHRSX]]|0.536|
|[[:human genes:p:pmvk|PMVK]]|0.535|
|[[:human genes:p:pnpt1|PNPT1]]|0.535|
|[[:human genes:a:atp5c1|ATP5C1]]|0.535|
|[[:human genes:m:mrps23|MRPS23]]|0.534|
|[[:human genes:m:mtg1|MTG1]]|0.534|
|[[:human genes:t:trmt61a|TRMT61A]]|0.534|
|[[:human genes:a:atp5a1|ATP5A1]]|0.533|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.53|
|[[:human genes:m:mrpl44|MRPL44]]|0.529|
|[[:human genes:s:slc25a26|SLC25A26]]|0.529|
|[[:human genes:c:cox15|COX15]]|0.525|
|[[:human genes:t:tufm|TUFM]]|0.524|
|[[:human genes:m:mrps7|MRPS7]]|0.523|
|[[:human genes:c:c12orf65|C12orf65]]|0.52|
|[[:human genes:c:cox7b|COX7B]]|0.519|
|[[:human genes:m:malsu1|MALSU1]]|0.519|
|[[:human genes:m:mrpl22|MRPL22]]|0.518|
|[[:human genes:a:aifm1|AIFM1]]|0.517|
|[[:human genes:c:cars2|CARS2]]|0.514|
|[[:human genes:m:mrps11|MRPS11]]|0.51|
|[[:human genes:t:trub2|TRUB2]]|0.509|
|[[:human genes:n:ndufa2|NDUFA2]]|0.508|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.508|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.504|
|[[:human genes:m:mrpl2|MRPL2]]|0.504|
|[[:human genes:m:mrpl18|MRPL18]]|0.502|
|[[:human genes:t:tmem242|TMEM242]]|0.501|
|[[:human genes:c:cox17|COX17]]|0.5|
|[[:human genes:m:mrpl43|MRPL43]]|0.5|
|[[:human genes:m:mrpl34|MRPL34]]|0.5|
|[[:human genes:m:mrpl39|MRPL39]]|0.499|
|[[:human genes:n:ndufb6|NDUFB6]]|0.494|
|[[:human genes:m:mrpl11|MRPL11]]|0.494|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.493|
|[[:human genes:m:mterfd2|MTERFD2]]|0.492|
|[[:human genes:n:ndufa1|NDUFA1]]|0.491|
|[[:human genes:l:lsm10|LSM10]]|0.491|
|[[:human genes:m:mrps27|MRPS27]]|0.49|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.488|
|[[:human genes:c:coq2|COQ2]]|0.488|
|[[:human genes:p:ptpmt1|PTPMT1]]|0.486|
|[[:human genes:p:pdss1|PDSS1]]|0.485|
|[[:human genes:e:elac2|ELAC2]]|0.484|
|[[:human genes:t:tfb1m|TFB1M]]|0.482|
|[[:human genes:m:mcat|MCAT]]|0.479|
|[[:human genes:a:atp5b|ATP5B]]|0.477|
|[[:human genes:n:ndufc2|NDUFC2]]|0.477|
|[[:human genes:m:mtpap|MTPAP]]|0.476|
|[[:human genes:m:mrpl51|MRPL51]]|0.476|
|[[:human genes:a:acad9|ACAD9]]|0.475|
|[[:human genes:m:mtif2|MTIF2]]|0.475|
|[[:human genes:r:rpia|RPIA]]|0.475|
|[[:human genes:n:ndufb5|NDUFB5]]|0.474|
|[[:human genes:m:mterfd1|MTERFD1]]|0.473|
|[[:human genes:d:ddx28|DDX28]]|0.473|
|[[:human genes:o:opa1|OPA1]]|0.472|
|[[:human genes:c:chchd1|CHCHD1]]|0.472|
|[[:human genes:s:ssbp1|SSBP1]]|0.472|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.469|
|[[:human genes:s:srd5a3|SRD5A3]]|0.468|
|[[:human genes:f:fh|FH]]|0.468|
|[[:human genes:c:c17orf89|C17orf89]]|0.468|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.467|
|[[:human genes:t:tomm20|TOMM20]]|0.467|
|[[:human genes:n:ndufs2|NDUFS2]]|0.466|
|[[:human genes:r:rft1|RFT1]]|0.466|
|[[:human genes:m:mrpl55|MRPL55]]|0.465|
|[[:human genes:a:alg8|ALG8]]|0.464|
|[[:human genes:e:eral1|ERAL1]]|0.464|
|[[:human genes:m:mrpl17|MRPL17]]|0.464|
|[[:human genes:c:cox20|COX20]]|0.462|
|[[:human genes:s:slc25a3|SLC25A3]]|0.458|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.457|
|[[:human genes:c:coq7|COQ7]]|0.456|
|[[:human genes:a:aldh18a1|ALDH18A1]]|0.455|
|[[:human genes:a:atp5sl|ATP5SL]]|0.454|
|[[:human genes:m:mrpl36|MRPL36]]|0.454|
|[[:human genes:i:iba57|IBA57]]|0.453|
|[[:human genes:d:dhx30|DHX30]]|0.452|
|[[:human genes:m:mtif3|MTIF3]]|0.452|
|[[:human genes:t:timm8b|TIMM8B]]|0.45|
|[[:human genes:a:alg6|ALG6]]|0.449|
|[[:human genes:c:coq3|COQ3]]|0.448|
|[[:human genes:t:tmem261|TMEM261]]|0.447|
|[[:human genes:m:mrpl13|MRPL13]]|0.446|
|[[:human genes:t:tfam|TFAM]]|0.446|
|[[:human genes:m:minos1|MINOS1]]|0.445|
|[[:human genes:p:ppcdc|PPCDC]]|0.445|
|[[:human genes:p:ptcd3|PTCD3]]|0.443|
|[[:human genes:t:tomm6|TOMM6]]|0.443|
|[[:human genes:t:tfb2m|TFB2M]]|0.443|
|[[:human genes:u:uqcr10|UQCR10]]|0.443|
|[[:human genes:c:cox5a|COX5A]]|0.442|
|[[:human genes:t:triap1|TRIAP1]]|0.442|
|[[:human genes:c:coa5|COA5]]|0.442|
|[[:human genes:c:chchd4|CHCHD4]]|0.44|
|[[:human genes:m:mrpl52|MRPL52]]|0.439|
|[[:human genes:p:ptcd1|PTCD1]]|0.439|
|[[:human genes:a:atp5h|ATP5H]]|0.439|
|[[:human genes:r:romo1|ROMO1]]|0.438|
|[[:human genes:p:ppcs|PPCS]]|0.435|
|[[:human genes:c:cox19|COX19]]|0.433|
|[[:human genes:t:tpk1|TPK1]]|0.433|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.433|
|[[:human genes:n:ndufa11|NDUFA11]]|0.432|
|[[:human genes:p:pet100|PET100]]|0.432|
|[[:human genes:m:mrpl46|MRPL46]]|0.431|
|[[:human genes:m:mrpl33|MRPL33]]|0.431|
|[[:human genes:s:sec62|SEC62]]|0.431|
|[[:human genes:c:cox6c|COX6C]]|0.43|
|[[:human genes:p:pitrm1|PITRM1]]|0.43|
|[[:human genes:g:g6pd|G6PD]]|0.43|
|[[:human genes:m:mrps22|MRPS22]]|0.43|
|[[:human genes:c:crls1|CRLS1]]|0.429|
|[[:human genes:a:atp5e|ATP5E]]|0.429|
|[[:human genes:f:fastkd2|FASTKD2]]|0.429|
|[[:human genes:m:mrps17|MRPS17]]|0.429|
|[[:human genes:p:pgs1|PGS1]]|0.425|
|[[:human genes:m:mipep|MIPEP]]|0.425|
|[[:human genes:n:ndufb9|NDUFB9]]|0.425|
|[[:human genes:m:mrpl37|MRPL37]]|0.424|
|[[:human genes:k:kdsr|KDSR]]|0.422|
|[[:human genes:m:mrpl28|MRPL28]]|0.422|
|[[:human genes:g:grsf1|GRSF1]]|0.422|
|[[:human genes:s:slc25a52|SLC25A52]]|0.422|
|[[:human genes:p:ppa2|PPA2]]|0.422|
|[[:human genes:d:dolk|DOLK]]|0.422|
|[[:human genes:s:ssb|SSB]]|0.421|
|[[:human genes:n:ndufc1|NDUFC1]]|0.419|
|[[:human genes:n:nsun4|NSUN4]]|0.419|
|[[:human genes:a:atp5l|ATP5L]]|0.418|
|[[:human genes:h:higd2a|HIGD2A]]|0.418|
|[[:human genes:t:taz|TAZ]]|0.414|
|[[:human genes:c:cox6b1|COX6B1]]|0.414|
|[[:human genes:f:fastkd1|FASTKD1]]|0.412|
|[[:human genes:s:slc25a51|SLC25A51]]|0.411|
|[[:human genes:e:ecsit|ECSIT]]|0.411|
|[[:human genes:m:mrpl41|MRPL41]]|0.409|
|[[:human genes:u:uqcc2|UQCC2]]|0.409|
|[[:human genes:n:nubpl|NUBPL]]|0.408|
|[[:human genes:c:coq6|COQ6]]|0.408|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.406|
|[[:human genes:a:atp5o|ATP5O]]|0.405|
|[[:human genes:m:mettl1|METTL1]]|0.405|
|[[:human genes:n:ndufs7|NDUFS7]]|0.404|
|[[:human genes:m:mrpl35|MRPL35]]|0.404|
|[[:human genes:l:lrpprc|LRPPRC]]|0.404|
|[[:human genes:m:mrps28|MRPS28]]|0.403|
|[[:human genes:n:ndufa10|NDUFA10]]|0.402|
|[[:human genes:c:coq5|COQ5]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 37/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|3/28|
|bone|1/26|
|breast|2/33|
|central nervous system|1/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|2/21|
|liver|2/20|
|lung|4/75|
|lymphocyte|2/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1030
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PARS2 Expression in NALM6 Cells: 2.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>