======= PCK2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PCK2
  * **<color #00a2e8>Official Name</color>**: phosphoenolpyruvate carboxykinase 2, mitochondrial
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5106|5106]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16822|Q16822]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PCK2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PCK2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614095|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PEPCK|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphoenolpyruvate carboxykinase activity|
|glycerol biosynthetic process from pyruvate|
|propionate catabolic process|
|phosphoenolpyruvate carboxykinase (GTP) activity|
|glycerol biosynthetic process|
|propionate metabolic process|
|alditol biosynthetic process|
|short-chain fatty acid catabolic process|
|hepatocyte differentiation|
|short-chain fatty acid metabolic process|
|triglyceride biosynthetic process|
|glycerol metabolic process|
|acylglycerol biosynthetic process|
|neutral lipid biosynthetic process|
|alditol metabolic process|
|cellular response to dexamethasone stimulus|
|response to dexamethasone|
|gluconeogenesis|
|hexose biosynthetic process|
|antibiotic catabolic process|
|monosaccharide biosynthetic process|
|cellular response to glucocorticoid stimulus|
|cellular response to corticosteroid stimulus|
|polyol biosynthetic process|
|cellular carbohydrate biosynthetic process|
|manganese ion binding|
|cellular response to glucose stimulus|
|pyruvate metabolic process|
|cellular response to hexose stimulus|
|cellular response to monosaccharide stimulus|
|triglyceride metabolic process|
|cellular response to carbohydrate stimulus|
|cellular glucose homeostasis|
|cellular response to ketone|
|fatty acid catabolic process|
|response to antineoplastic agent|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|antibiotic metabolic process|
|polyol metabolic process|
|alcohol biosynthetic process|
|glucose metabolic process|
|monocarboxylic acid catabolic process|
|liver development|
|carbohydrate biosynthetic process|
|hepaticobiliary system development|
|response to glucose|
|response to hexose|
|response to glucocorticoid|
|drug catabolic process|
|response to monosaccharide|
|hexose metabolic process|
|response to corticosteroid|
|cellular response to insulin stimulus|
|cellular carbohydrate metabolic process|
|response to carbohydrate|
|glucose homeostasis|
|organic hydroxy compound biosynthetic process|
|carbohydrate homeostasis|
|cellular response to xenobiotic stimulus|
|cellular response to steroid hormone stimulus|
|response to ketone|
|response to starvation|
|cellular lipid catabolic process|
|monosaccharide metabolic process|
|glycerolipid biosynthetic process|
|response to insulin|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|cellular response to peptide hormone stimulus|
|lipid catabolic process|
|response to xenobiotic stimulus|
|alcohol metabolic process|
|fatty acid metabolic process|
|cellular response to peptide|
|response to steroid hormone|
|mitochondrial matrix|
|glycerolipid metabolic process|
|GTP binding|
|response to peptide hormone|
|cellular response to drug|
|gland development|
|small molecule catabolic process|
|organic hydroxy compound metabolic process|
|response to peptide|
|carbohydrate metabolic process|
|response to nutrient levels|
|drug metabolic process|
|cellular response to lipid|
|monocarboxylic acid metabolic process|
|response to extracellular stimulus|
|cellular response to organic cyclic compound|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|epithelial cell differentiation|
|cellular chemical homeostasis|
|response to lipid|
|cellular homeostasis|
|response to hormone|
|carboxylic acid metabolic process|
|response to organic cyclic compound|
|cellular lipid metabolic process|
|response to organonitrogen compound|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|chemical homeostasis|
|epithelium development|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|mitochondrion|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|homeostatic process|
|small molecule metabolic process|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-1.92|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|-1.91|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-1.78|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4907
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PCK2 Expression in NALM6 Cells: 5.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>