======= PCLO =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PCLO
  * **<color #00a2e8>Official Name</color>**: piccolo presynaptic cytomatrix protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27445|27445]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6V0|Q9Y6V0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PCLO&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PCLO|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604918|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is part of the presynaptic cytoskeletal matrix, which is involved in establishing active synaptic zones and in synaptic vesicle trafficking. Variations in this gene have been associated with bipolar disorder and major depressive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking. {ECO:0000250|UniProtKB:Q9QYX7}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C2|
|PDZ|
|zf-piccolo|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|presynaptic signal transduction|
|presynapse to nucleus signaling pathway|
|structural constituent of presynaptic active zone|
|maintenance of presynaptic active zone structure|
|cytoskeleton of presynaptic active zone|
|presynaptic active zone organization|
|synaptic vesicle clustering|
|profilin binding|
|maintenance of synapse structure|
|insulin secretion|
|synaptic vesicle localization|
|cellular component maintenance|
|calcium-dependent phospholipid binding|
|peptide hormone secretion|
|protein localization to synapse|
|synaptic vesicle exocytosis|
|hormone secretion|
|hormone transport|
|synapse assembly|
|signal release from synapse|
|neurotransmitter secretion|
|synaptic vesicle cycle|
|vesicle-mediated transport in synapse|
|cAMP-mediated signaling|
|protein secretion|
|establishment of protein localization to extracellular region|
|protein localization to extracellular region|
|signal release|
|cyclic-nucleotide-mediated signaling|
|peptide secretion|
|neurotransmitter transport|
|vesicle localization|
|regulation of exocytosis|
|postsynaptic density|
|synapse|
|synapse organization|
|second-messenger-mediated signaling|
|regulation of neurotransmitter levels|
|cytoskeleton|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|trans-synaptic signaling|
|synaptic signaling|
|regulation of hormone levels|
|cell junction|
|regulation of vesicle-mediated transport|
|organelle localization|
|regulated exocytosis|
|calcium ion binding|
|regulation of secretion by cell|
|exocytosis|
|regulation of secretion|
|secretion by cell|
|export from cell|
|cytoskeleton organization|
|cell-cell signaling|
|secretion|
|protein transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.94|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6872
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PCLO Expression in NALM6 Cells: -2.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>