======= PCM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PCM1
  * **<color #00a2e8>Official Name</color>**: pericentriolar material 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5108|5108]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15154|Q15154]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PCM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PCM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600299|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome. Involved in the biogenesis of cilia. {ECO:0000269|PubMed:12403812, ECO:0000269|PubMed:15659651, ECO:0000269|PubMed:16943179, ECO:0000269|PubMed:20551181, ECO:0000269|PubMed:24121310}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interkinetic nuclear migration|
|microtubule anchoring at centrosome|
|microtubule anchoring at microtubule organizing center|
|protein localization to centrosome|
|pericentriolar material|
|protein localization to microtubule organizing center|
|neuronal stem cell population maintenance|
|nuclear migration|
|microtubule anchoring|
|nucleus localization|
|cell proliferation in forebrain|
|ciliary transition zone|
|centriolar satellite|
|non-motile cilium|
|protein localization to microtubule cytoskeleton|
|protein localization to cytoskeleton|
|intraciliary transport involved in cilium assembly|
|non-motile cilium assembly|
|intraciliary transport|
|social behavior|
|intraspecies interaction between organisms|
|cytoplasmic microtubule organization|
|microtubule-based protein transport|
|protein transport along microtubule|
|multi-organism behavior|
|apical part of cell|
|neural precursor cell proliferation|
|centrosome cycle|
|microtubule organizing center organization|
|ciliary basal body-plasma membrane docking|
|neuron migration|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|stem cell population maintenance|
|ciliary basal body|
|maintenance of cell number|
|centriole|
|positive regulation of intracellular protein transport|
|transport along microtubule|
|organelle localization by membrane tethering|
|cytoskeleton-dependent intracellular transport|
|membrane docking|
|microtubule-based transport|
|regulation of G2/M transition of mitotic cell cycle|
|positive regulation of intracellular transport|
|regulation of cell cycle G2/M phase transition|
|regulation of intracellular protein transport|
|nuclear membrane|
|protein-containing complex localization|
|mitotic cell cycle phase transition|
|microtubule-based movement|
|cell cycle phase transition|
|negative regulation of neurogenesis|
|negative regulation of nervous system development|
|positive regulation of cellular protein localization|
|negative regulation of cell development|
|cilium assembly|
|regulation of intracellular transport|
|establishment of organelle localization|
|cilium organization|
|forebrain development|
|regulation of mitotic cell cycle phase transition|
|positive regulation of protein transport|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|supramolecular fiber organization|
|cell projection assembly|
|positive regulation of establishment of protein localization|
|microtubule cytoskeleton organization|
|centrosome|
|regulation of cellular protein localization|
|cell population proliferation|
|behavior|
|organelle localization|
|protein-containing complex|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|microtubule-based process|
|mitotic cell cycle|
|regulation of protein transport|
|negative regulation of cell differentiation|
|protein localization to organelle|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|regulation of cell cycle process|
|organelle assembly|
|head development|
|regulation of neurogenesis|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|cell migration|
|central nervous system development|
|positive regulation of transport|
|intracellular protein transport|
|cell cycle process|
|regulation of protein localization|
|identical protein binding|
|localization of cell|
|cell motility|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|locomotion|
|cell cycle|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|regulation of cell differentiation|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.95|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-1.93|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.86|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-1.85|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|2/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13892
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PCM1 Expression in NALM6 Cells: 7.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>