======= PCSK5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PCSK5
  * **<color #00a2e8>Official Name</color>**: proprotein convertase subtilisin/kexin type 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5125|5125]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92824|Q92824]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PCSK5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PCSK5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600488|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B). [provided by RefSeq, May 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. {ECO:0000269|PubMed:19764806, ECO:0000269|PubMed:20555025, ECO:0000269|PubMed:22740495}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|VSP|
|P proprotein|
|Peptidase S8|
|PLAC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure|
|renin secretion into blood stream|
|nerve growth factor processing|
|signal peptide processing|
|cytokine biosynthetic process|
|cytokine metabolic process|
|regulation of systemic arterial blood pressure by circulatory renin-angiotensin|
|regulation of lipoprotein lipase activity|
|regulation of systemic arterial blood pressure by renin-angiotensin|
|renal system process involved in regulation of systemic arterial blood pressure|
|peptide hormone processing|
|embryonic digestive tract development|
|regulation of systemic arterial blood pressure by hormone|
|embryo implantation|
|coronary vasculature development|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|endocrine process|
|peptide binding|
|integral component of Golgi membrane|
|endopeptidase activity|
|peptidase activity|
|secretory granule|
|regulation of systemic arterial blood pressure|
|regulation of lipase activity|
|Golgi lumen|
|cardiac septum development|
|renal system process|
|determination of left/right symmetry|
|determination of bilateral symmetry|
|specification of symmetry|
|embryonic skeletal system development|
|digestive tract development|
|digestive system development|
|limb morphogenesis|
|cytokine production|
|appendage morphogenesis|
|protein secretion|
|protein processing|
|establishment of protein localization to extracellular region|
|serine-type endopeptidase activity|
|protein localization to extracellular region|
|cardiac chamber development|
|trans-Golgi network|
|respiratory tube development|
|peptide secretion|
|appendage development|
|limb development|
|female pregnancy|
|regulation of blood pressure|
|viral life cycle|
|hormone metabolic process|
|multi-multicellular organism process|
|anterior/posterior pattern specification|
|protein maturation|
|kidney development|
|renal system development|
|urogenital system development|
|regionalization|
|blood circulation|
|circulatory system process|
|peptide biosynthetic process|
|embryonic organ development|
|pattern specification process|
|blood vessel development|
|skeletal system development|
|vasculature development|
|cardiovascular system development|
|heart development|
|amide biosynthetic process|
|peptide metabolic process|
|regulation of hormone levels|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|viral process|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|tube development|
|circulatory system development|
|embryo development|
|Golgi apparatus|
|multi-organism reproductive process|
|secretion by cell|
|export from cell|
|cell-cell signaling|
|secretion|
|proteolysis|
|regulation of hydrolase activity|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|protein transport|
|peptide transport|
|amide transport|
|extracellular space|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|macromolecule biosynthetic process|
|nitrogen compound transport|
|extracellular region|
|system process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.95|
|[[:results:exp518|RK-33 8μM R08 exp518]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11791
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PCSK5 Expression in NALM6 Cells: 3.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>