======= PCYT2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PCYT2
  * **<color #00a2e8>Official Name</color>**: phosphate cytidylyltransferase 2, ethanolamine
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5833|5833]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99447|Q99447]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PCYT2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PCYT2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602679|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the formation of CDP-ethanolamine.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CTP transf 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ethanolamine-phosphate cytidylyltransferase activity|
|phosphatidylethanolamine biosynthetic process|
|phosphatidylethanolamine metabolic process|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|glycerophospholipid metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|cellular component|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|organophosphate metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|lipid metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-3|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-2.9|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.89|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.75|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.59|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|-2.3|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-2.21|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-2.19|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-2.06|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.02|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|-2|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|-1.97|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.89|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.88|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.81|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|-1.8|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-1.79|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-1.79|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-1.76|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-1.76|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|-1.74|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-1.72|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.71|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.76|
|[[:results:exp518|RK-33 8μM R08 exp518]]|1.86|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.06|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|2.16|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.21|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:ept1|EPT1]]|0.527|
|[[:human genes:p:pex7|PEX7]]|0.431|
|[[:human genes:p:pex1|PEX1]]|0.412|
|[[:human genes:a:arpc4|ARPC4]]|0.406|
|[[:human genes:a:acsl4|ACSL4]]|0.404|
|[[:human genes:e:etnk1|ETNK1]]|0.401|
|[[:human genes:t:tmem189|TMEM189]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3919
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PCYT2 Expression in NALM6 Cells: 5.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>