======= PDAP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDAP1
  * **<color #00a2e8>Official Name</color>**: PDGFA associated protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11333|11333]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13442|Q13442]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDAP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDAP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607075|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a phosphoprotein that may upregulate the PDGFA-stimulated growth of fibroblasts and also downregulate the mitogenicity of PDGFB. The encoded protein in rodents has been shown to bind PDGFA with a low affinity. [provided by RefSeq, Dec 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Enhances PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PP28|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ficolin-1-rich granule lumen|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|leukocyte activation|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|RNA binding|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-2.46|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.45|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-2.42|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|-2.34|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.27|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-2.21|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2.19|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.17|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.14|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-2.12|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-2.06|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-2.03|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|-1.98|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.93|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.86|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.83|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|-1.79|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-1.79|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-1.75|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.74|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|-1.73|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.73|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-1.71|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.71|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-1.71|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.71|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.94|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|2.05|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.563|
|[[:human genes:u:uap1|UAP1]]|0.515|
|[[:human genes:m:mbtps2|MBTPS2]]|0.507|
|[[:human genes:r:rptor|RPTOR]]|0.502|
|[[:human genes:t:ttc4|TTC4]]|0.497|
|[[:human genes:d:dpagt1|DPAGT1]]|0.493|
|[[:human genes:u:urm1|URM1]]|0.491|
|[[:human genes:p:ppp6c|PPP6C]]|0.487|
|[[:human genes:d:dohh|DOHH]]|0.486|
|[[:human genes:e:eef1e1|EEF1E1]]|0.483|
|[[:human genes:a:alg1|ALG1]]|0.482|
|[[:human genes:t:trmt10a|TRMT10A]]|0.478|
|[[:human genes:d:dhrsx|DHRSX]]|0.477|
|[[:human genes:e:elp3|ELP3]]|0.464|
|[[:human genes:p:pmm2|PMM2]]|0.464|
|[[:human genes:e:eif1|EIF1]]|0.462|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.46|
|[[:human genes:s:srp14|SRP14]]|0.459|
|[[:human genes:s:sec63|SEC63]]|0.458|
|[[:human genes:g:gmppb|GMPPB]]|0.457|
|[[:human genes:t:trmt61a|TRMT61A]]|0.454|
|[[:human genes:p:pelo|PELO]]|0.45|
|[[:human genes:n:nsd1|NSD1]]|0.45|
|[[:human genes:r:rpp21|RPP21]]|0.45|
|[[:human genes:r:rnmt|RNMT]]|0.449|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.445|
|[[:human genes:m:med16|MED16]]|0.445|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.444|
|[[:human genes:s:sec62|SEC62]]|0.443|
|[[:human genes:e:exoc4|EXOC4]]|0.443|
|[[:human genes:x:xpot|XPOT]]|0.443|
|[[:human genes:k:kdsr|KDSR]]|0.434|
|[[:human genes:o:oraov1|ORAOV1]]|0.434|
|[[:human genes:e:elp2|ELP2]]|0.432|
|[[:human genes:m:mtor|MTOR]]|0.43|
|[[:human genes:a:alg6|ALG6]]|0.429|
|[[:human genes:b:bap1|BAP1]]|0.429|
|[[:human genes:t:tsen54|TSEN54]]|0.428|
|[[:human genes:r:rtcb|RTCB]]|0.425|
|[[:human genes:f:fh|FH]]|0.424|
|[[:human genes:t:ten1|TEN1]]|0.424|
|[[:human genes:t:trim28|TRIM28]]|0.424|
|[[:human genes:c:cmtr1|CMTR1]]|0.424|
|[[:human genes:z:znf608|ZNF608]]|0.422|
|[[:human genes:e:elp6|ELP6]]|0.422|
|[[:human genes:r:romo1|ROMO1]]|0.421|
|[[:human genes:g:gfpt1|GFPT1]]|0.419|
|[[:human genes:t:tmem41b|TMEM41B]]|0.418|
|[[:human genes:d:dnajc3|DNAJC3]]|0.418|
|[[:human genes:s:ssb|SSB]]|0.416|
|[[:human genes:a:atxn10|ATXN10]]|0.413|
|[[:human genes:v:vezt|VEZT]]|0.413|
|[[:human genes:a:alg2|ALG2]]|0.408|
|[[:human genes:t:trmt5|TRMT5]]|0.406|
|[[:human genes:t:triap1|TRIAP1]]|0.406|
|[[:human genes:c:ctu1|CTU1]]|0.406|
|[[:human genes:s:slc25a19|SLC25A19]]|0.405|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.405|
|[[:human genes:n:nrd1|NRD1]]|0.404|
|[[:human genes:t:tti2|TTI2]]|0.404|
|[[:human genes:d:dnlz|DNLZ]]|0.403|
|[[:human genes:l:lsm11|LSM11]]|0.402|
|[[:human genes:u:ube2g2|UBE2G2]]|0.402|
|[[:human genes:x:xpo6|XPO6]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 462/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|17/28|
|blood|20/28|
|bone|15/26|
|breast|17/33|
|central nervous system|28/56|
|cervix|1/4|
|colorectal|15/17|
|esophagus|4/13|
|fibroblast|1/1|
|gastric|9/16|
|kidney|15/21|
|liver|17/20|
|lung|49/75|
|lymphocyte|10/16|
|ovary|10/26|
|pancreas|18/24|
|peripheral nervous system|11/16|
|plasma cell|5/15|
|prostate|1/1|
|skin|18/24|
|soft tissue|7/9|
|thyroid|1/2|
|upper aerodigestive|15/22|
|urinary tract|20/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6028
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDAP1 Expression in NALM6 Cells: 6.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>