======= PDCD10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDCD10
  * **<color #00a2e8>Official Name</color>**: programmed cell death 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11235|11235]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BUL8|Q9BUL8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDCD10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDCD10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609118|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity (PubMed:27807006). Important for cell migration, and for normal structure and assembly of the Golgi complex (PubMed:27807006). Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). {ECO:0000250|UniProtKB:Q8VE70, ECO:0000269|PubMed:15543491, ECO:0000269|PubMed:17360971, ECO:0000269|PubMed:20332113, ECO:0000269|PubMed:27807006}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1241|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|programmed cell death in response to reactive oxygen species|
|intrinsic apoptotic signaling pathway in response to hydrogen peroxide|
|hydrogen peroxide-mediated programmed cell death|
|cell death in response to hydrogen peroxide|
|Golgi reassembly|
|negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|
|establishment of Golgi localization|
|organelle inheritance|
|Golgi inheritance|
|regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|
|Golgi localization|
|negative regulation of cell migration involved in sprouting angiogenesis|
|intrinsic apoptotic signaling pathway in response to oxidative stress|
|contractile actin filament bundle assembly|
|stress fiber assembly|
|cell death in response to oxidative stress|
|negative regulation of sprouting angiogenesis|
|wound healing, spreading of cells|
|epiboly involved in wound healing|
|epiboly|
|negative regulation of blood vessel endothelial cell migration|
|negative regulation of endothelial cell proliferation|
|regulation of cell migration involved in sprouting angiogenesis|
|negative regulation of endothelial cell migration|
|morphogenesis of an epithelial sheet|
|positive regulation of Notch signaling pathway|
|actin filament bundle assembly|
|actin filament bundle organization|
|negative regulation of epithelial cell migration|
|regulation of sprouting angiogenesis|
|cellular response to hydrogen peroxide|
|regulation of blood vessel endothelial cell migration|
|response to leukemia inhibitory factor|
|cellular response to leukemia inhibitory factor|
|regulation of Notch signaling pathway|
|negative regulation of angiogenesis|
|positive regulation of peptidyl-serine phosphorylation|
|negative regulation of blood vessel morphogenesis|
|protein N-terminus binding|
|actomyosin structure organization|
|negative regulation of vasculature development|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|negative regulation of epithelial cell proliferation|
|regulation of endothelial cell proliferation|
|cellular response to reactive oxygen species|
|Golgi organization|
|regulation of peptidyl-serine phosphorylation|
|regulation of Rho protein signal transduction|
|intrinsic apoptotic signaling pathway|
|positive regulation of intracellular protein transport|
|regulation of endothelial cell migration|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|protein stabilization|
|response to reactive oxygen species|
|positive regulation of intracellular transport|
|cellular response to toxic substance|
|regulation of epithelial cell migration|
|regulation of intracellular protein transport|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|actin filament organization|
|cellular response to oxidative stress|
|regulation of Ras protein signal transduction|
|negative regulation of cell migration|
|positive regulation of MAP kinase activity|
|negative regulation of cell motility|
|apoptotic signaling pathway|
|regulation of protein stability|
|regulation of angiogenesis|
|response to antibiotic|
|negative regulation of cellular component movement|
|angiogenesis|
|regulation of vasculature development|
|negative regulation of locomotion|
|positive regulation of cellular protein localization|
|regulation of epithelial cell proliferation|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|regulation of small GTPase mediated signal transduction|
|regulation of intracellular transport|
|establishment of organelle localization|
|response to oxidative stress|
|cellular response to drug|
|blood vessel morphogenesis|
|endomembrane system organization|
|positive regulation of protein transport|
|morphogenesis of an epithelium|
|supramolecular fiber organization|
|positive regulation of establishment of protein localization|
|protein kinase binding|
|wound healing|
|blood vessel development|
|actin cytoskeleton organization|
|positive regulation of cell migration|
|response to toxic substance|
|vasculature development|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|positive regulation of cell motility|
|positive regulation of protein kinase activity|
|response to inorganic substance|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|positive regulation of MAPK cascade|
|positive regulation of locomotion|
|tissue morphogenesis|
|actin filament-based process|
|response to wounding|
|positive regulation of kinase activity|
|organelle localization|
|Golgi membrane|
|tube morphogenesis|
|positive regulation of transferase activity|
|negative regulation of cell population proliferation|
|regulation of protein transport|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of MAPK cascade|
|regulation of protein kinase activity|
|tube development|
|regulation of cell migration|
|circulatory system development|
|regulation of kinase activity|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|apoptotic process|
|negative regulation of developmental process|
|cell migration|
|regulation of transferase activity|
|regulation of locomotion|
|Golgi apparatus|
|positive regulation of transport|
|negative regulation of cell death|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|programmed cell death|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|cell death|
|response to cytokine|
|cytoskeleton organization|
|epithelium development|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|locomotion|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.24|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.22|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-2.22|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-1.99|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.94|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.9|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.86|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.85|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-1.82|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-1.81|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-1.79|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-1.78|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.73|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-1.72|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.71|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.81|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.82|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.95|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.97|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|2.01|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.09|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.22|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.24|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|2.34|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.47|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.66|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:ccm2|CCM2]]|0.51|
|[[:human genes:m:mesdc1|MESDC1]]|0.439|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4351
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDCD10 Expression in NALM6 Cells: 4.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>