======= PDCD2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDCD2
  * **<color #00a2e8>Official Name</color>**: programmed cell death 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5134|5134]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16342|Q16342]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDCD2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDCD2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600866|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-MYND|
|PDCD2 C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of hematopoietic stem cell proliferation|
|regulation of hematopoietic stem cell proliferation|
|positive regulation of stem cell proliferation|
|regulation of stem cell proliferation|
|regulation of hematopoietic progenitor cell differentiation|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of cysteine-type endopeptidase activity|
|positive regulation of endopeptidase activity|
|positive regulation of hemopoiesis|
|positive regulation of peptidase activity|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of cysteine-type endopeptidase activity|
|enzyme binding|
|positive regulation of proteolysis|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|regulation of hemopoiesis|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|regulation of proteolysis|
|positive regulation of hydrolase activity|
|positive regulation of cell population proliferation|
|apoptotic process|
|programmed cell death|
|cell death|
|positive regulation of immune system process|
|regulation of hydrolase activity|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|DNA binding|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.436|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 653/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|25/28|
|blood|23/28|
|bone|25/26|
|breast|27/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|14/17|
|esophagus|9/13|
|fibroblast|1/1|
|gastric|14/16|
|kidney|20/21|
|liver|18/20|
|lung|62/75|
|lymphocyte|12/16|
|ovary|23/26|
|pancreas|21/24|
|peripheral nervous system|13/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|18/22|
|urinary tract|29/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 956
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDCD2 Expression in NALM6 Cells: 6.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>