======= PDCD6IP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDCD6IP
  * **<color #00a2e8>Official Name</color>**: programmed cell death 6 interacting protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10015|10015]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WUM4|Q8WUM4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDCD6IP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDCD6IP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608074|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. [provided by RefSeq, Jan 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes (PubMed:14739459). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:17853893, PubMed:17556548). Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis (PubMed:17853893, PubMed:17556548, PubMed:18641129). May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (PubMed:22660413). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity). {ECO:0000250|UniProtKB:Q9WU78, ECO:0000269|PubMed:14739459, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:18641129, ECO:0000269|PubMed:22660413}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BRO1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|proteinase activated receptor binding|
|positive regulation of extracellular exosome assembly|
|actomyosin contractile ring assembly|
|assembly of actomyosin apparatus involved in cytokinesis|
|ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway|
|regulation of extracellular exosome assembly|
|actomyosin contractile ring organization|
|maintenance of apical/basal cell polarity|
|maintenance of epithelial cell apical/basal polarity|
|actomyosin|
|positive regulation of exosomal secretion|
|midbody abscission|
|maintenance of cell polarity|
|regulation of exosomal secretion|
|viral budding via host ESCRT complex|
|mitotic cytokinetic process|
|regulation of mitotic spindle assembly|
|viral budding|
|regulation of spindle assembly|
|endoplasmic reticulum exit site|
|Flemming body|
|multivesicular body assembly|
|multivesicular body organization|
|immunological synapse|
|bicellular tight junction assembly|
|cytokinetic process|
|tight junction assembly|
|virion assembly|
|tight junction organization|
|regulation of mitotic spindle organization|
|cortical actin cytoskeleton organization|
|regulation of centrosome duplication|
|regulation of spindle organization|
|apical junction assembly|
|establishment or maintenance of epithelial cell apical/basal polarity|
|mitotic metaphase plate congression|
|cortical cytoskeleton organization|
|establishment or maintenance of bipolar cell polarity|
|establishment or maintenance of apical/basal cell polarity|
|metaphase plate congression|
|extracellular vesicle|
|regulation of centrosome cycle|
|calcium-dependent protein binding|
|mitotic cytokinesis|
|establishment of chromosome localization|
|positive regulation of organelle assembly|
|chromosome localization|
|endosome organization|
|regulation of membrane permeability|
|positive regulation of exocytosis|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|melanosome|
|cell-cell junction assembly|
|mitotic sister chromatid segregation|
|actomyosin structure organization|
|bicellular tight junction|
|nucleus organization|
|cell-cell junction organization|
|sister chromatid segregation|
|mitotic nuclear division|
|microtubule organizing center|
|cell junction assembly|
|regulation of mitotic nuclear division|
|regulation of microtubule cytoskeleton organization|
|regulation of nuclear division|
|establishment or maintenance of cell polarity|
|viral life cycle|
|cell junction organization|
|nuclear chromosome segregation|
|regulation of organelle assembly|
|regulation of microtubule-based process|
|regulation of exocytosis|
|chromosome segregation|
|nuclear division|
|vesicle organization|
|organelle fission|
|protein homooligomerization|
|establishment of organelle localization|
|positive regulation of secretion by cell|
|focal adhesion|
|endomembrane system organization|
|positive regulation of secretion|
|cell division|
|actin cytoskeleton organization|
|protein complex oligomerization|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|regulation of vesicle-mediated transport|
|actin filament-based process|
|organelle localization|
|proteolysis involved in cellular protein catabolic process|
|mitotic cell cycle process|
|cellular protein catabolic process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|protein catabolic process|
|mitotic cell cycle|
|viral process|
|regulation of secretion by cell|
|regulation of cell cycle process|
|organelle assembly|
|symbiotic process|
|regulation of secretion|
|interspecies interaction between organisms|
|membrane organization|
|protein homodimerization activity|
|cellular macromolecule catabolic process|
|apoptotic process|
|regulation of cellular component biogenesis|
|positive regulation of transport|
|cell cycle process|
|macromolecule catabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|chromosome organization|
|cell death|
|cytoskeleton organization|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|proteolysis|
|regulation of organelle organization|
|cell cycle|
|protein transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|establishment of protein localization|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-2.28|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.17|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-2|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-1.87|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-1.82|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cxorf56|CXorf56]]|0.45|
|[[:human genes:k:kdm8|KDM8]]|0.447|
|[[:human genes:p:ppp6c|PPP6C]]|0.412|
|[[:human genes:u:uap1|UAP1]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 35/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|1/26|
|breast|4/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|0/21|
|liver|0/20|
|lung|3/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|2/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/9|
|thyroid|1/2|
|upper aerodigestive|2/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7588
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDCD6IP Expression in NALM6 Cells: 7.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>