======= PDE4DIP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDE4DIP
  * **<color #00a2e8>Official Name</color>**: phosphodiesterase 4D interacting protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9659|9659]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5VU43|Q5VU43]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDE4DIP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDE4DIP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608117|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene serves to anchor phosphodiesterase 4D to the Golgi/centrosome region of the cell. Defects in this gene may be a cause of myeloproliferative disorder (MBD) associated with eosinophilia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Microtub assoc|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of Golgi organization|
|myofibril|
|molecular adaptor activity|
|enzyme binding|
|centrosome|
|cellular protein-containing complex assembly|
|Golgi apparatus|
|regulation of organelle organization|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.71|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|1.75|
|[[:results:exp303|39°C R06 exp303]]|1.76|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|1.77|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|1.78|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cgb2|CGB2]]|0.511|
|[[:human genes:p:pole|POLE]]|0.507|
|[[:human genes:c:cbwd3|CBWD3]]|0.505|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.504|
|[[:human genes:p:psmb2|PSMB2]]|0.499|
|[[:human genes:s:supt5h|SUPT5H]]|0.498|
|[[:human genes:p:pola1|POLA1]]|0.497|
|[[:human genes:m:med17|MED17]]|0.496|
|[[:human genes:c:cbwd5|CBWD5]]|0.49|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.485|
|[[:human genes:m:myo18a|MYO18A]]|0.482|
|[[:human genes:c:cbwd6|CBWD6]]|0.478|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.476|
|[[:human genes:c:c14orf93|C14orf93]]|0.473|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.471|
|[[:human genes:n:npipb5|NPIPB5]]|0.469|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.468|
|[[:human genes:t:twistnb|TWISTNB]]|0.467|
|[[:human genes:c:ccna2|CCNA2]]|0.465|
|[[:human genes:c:cope|COPE]]|0.463|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.462|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.462|
|[[:human genes:k:kctd17|KCTD17]]|0.462|
|[[:human genes:v:vasn|VASN]]|0.46|
|[[:human genes:r:rps2|RPS2]]|0.459|
|[[:human genes:t:trim52|TRIM52]]|0.458|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.457|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.456|
|[[:human genes:s:ssh2|SSH2]]|0.456|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.455|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.454|
|[[:human genes:p:psmd2|PSMD2]]|0.454|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.454|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.454|
|[[:human genes:m:mdm2|MDM2]]|0.452|
|[[:human genes:o:orc6|ORC6]]|0.45|
|[[:human genes:s:stil|STIL]]|0.447|
|[[:human genes:s:slc4a1|SLC4A1]]|0.446|
|[[:human genes:u:upf1|UPF1]]|0.445|
|[[:human genes:p:psmb4|PSMB4]]|0.445|
|[[:human genes:t:ticrr|TICRR]]|0.444|
|[[:human genes:d:dtl|DTL]]|0.442|
|[[:human genes:r:rrn3|RRN3]]|0.44|
|[[:human genes:t:tfip11|TFIP11]]|0.439|
|[[:human genes:p:psmb3|PSMB3]]|0.439|
|[[:human genes:e:exosc5|EXOSC5]]|0.439|
|[[:human genes:p:paf1|PAF1]]|0.439|
|[[:human genes:m:myo1h|MYO1H]]|0.437|
|[[:human genes:p:psma6|PSMA6]]|0.434|
|[[:human genes:a:akirin2|AKIRIN2]]|0.432|
|[[:human genes:b:bid|BID]]|0.432|
|[[:human genes:p:psmc2|PSMC2]]|0.432|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.432|
|[[:human genes:n:npipb8|NPIPB8]]|0.431|
|[[:human genes:c:chd4|CHD4]]|0.429|
|[[:human genes:r:rrm2|RRM2]]|0.428|
|[[:human genes:l:lrr1|LRR1]]|0.428|
|[[:human genes:p:psmd7|PSMD7]]|0.428|
|[[:human genes:p:psmd8|PSMD8]]|0.428|
|[[:human genes:r:rps5|RPS5]]|0.427|
|[[:human genes:r:rbbp5|RBBP5]]|0.426|
|[[:human genes:r:rrp7a|RRP7A]]|0.426|
|[[:human genes:r:rpl35|RPL35]]|0.425|
|[[:human genes:a:ankle2|ANKLE2]]|0.425|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.423|
|[[:human genes:p:pwp2|PWP2]]|0.421|
|[[:human genes:a:acsf2|ACSF2]]|0.421|
|[[:human genes:l:lad1|LAD1]]|0.421|
|[[:human genes:p:plxnb3|PLXNB3]]|0.42|
|[[:human genes:s:sap30bp|SAP30BP]]|0.419|
|[[:human genes:s:snip1|SNIP1]]|0.418|
|[[:human genes:p:polr2l|POLR2L]]|0.418|
|[[:human genes:w:wdr75|WDR75]]|0.418|
|[[:human genes:z:zfand5|ZFAND5]]|0.416|
|[[:human genes:c:cep192|CEP192]]|0.415|
|[[:human genes:p:psmb1|PSMB1]]|0.414|
|[[:human genes:n:nup155|NUP155]]|0.414|
|[[:human genes:p:psmc1|PSMC1]]|0.413|
|[[:human genes:b:bysl|BYSL]]|0.411|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.41|
|[[:human genes:n:nup43|NUP43]]|0.41|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.409|
|[[:human genes:p:polr2j3|POLR2J3]]|0.409|
|[[:human genes:a:aqr|AQR]]|0.409|
|[[:human genes:m:myt1l|MYT1L]]|0.409|
|[[:human genes:t:tceb3c|TCEB3C]]|0.409|
|[[:human genes:n:nupl1|NUPL1]]|0.408|
|[[:human genes:i:iscu|ISCU]]|0.407|
|[[:human genes:s:slc6a17|SLC6A17]]|0.406|
|[[:human genes:k:krt78|KRT78]]|0.406|
|[[:human genes:p:psmd6|PSMD6]]|0.406|
|[[:human genes:n:nbpf16|NBPF16]]|0.405|
|[[:human genes:h:hap1|HAP1]]|0.405|
|[[:human genes:p:psmd3|PSMD3]]|0.405|
|[[:human genes:x:xylt2|XYLT2]]|0.404|
|[[:human genes:c:chaf1a|CHAF1A]]|0.404|
|[[:human genes:s:supt6h|SUPT6H]]|0.404|
|[[:human genes:c:copz1|COPZ1]]|0.403|
|[[:human genes:p:polr2j|POLR2J]]|0.402|
|[[:human genes:c:col2a1|COL2A1]]|0.4|
|[[:human genes:p:polr2f|POLR2F]]|0.4|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1999
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDE4DIP Expression in NALM6 Cells: 6.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>