======= PDGFD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDGFD
  * **<color #00a2e8>Official Name</color>**: platelet derived growth factor D
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80310|80310]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9GZP0|Q9GZP0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDGFD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDGFD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609673|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity). {ECO:0000250, ECO:0000269|PubMed:11331881, ECO:0000269|PubMed:15271796}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CUB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of monocyte extravasation|
|positive regulation of smooth muscle cell chemotaxis|
|regulation of monocyte extravasation|
|positive regulation of glomerular mesangial cell proliferation|
|regulation of smooth muscle cell chemotaxis|
|positive regulation of cell proliferation involved in kidney development|
|regulation of glomerular mesangial cell proliferation|
|positive regulation of glomerulus development|
|regulation of cell proliferation involved in kidney development|
|regulation of glomerulus development|
|platelet-derived growth factor receptor binding|
|positive regulation of cellular extravasation|
|cellular response to platelet-derived growth factor stimulus|
|response to platelet-derived growth factor|
|positive regulation of mononuclear cell migration|
|positive regulation of protein autophosphorylation|
|regulation of cellular extravasation|
|platelet-derived growth factor receptor signaling pathway|
|positive regulation of smooth muscle cell migration|
|positive regulation of kidney development|
|regulation of mononuclear cell migration|
|regulation of protein autophosphorylation|
|positive regulation of fibroblast proliferation|
|regulation of kidney development|
|regulation of smooth muscle cell migration|
|cellular response to amino acid stimulus|
|cellular response to hydrogen peroxide|
|regulation of fibroblast proliferation|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|positive regulation of smooth muscle cell proliferation|
|positive regulation of cell division|
|response to amino acid|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|regulation of phosphatidylinositol 3-kinase signaling|
|positive regulation of leukocyte migration|
|cellular response to reactive oxygen species|
|regulation of smooth muscle cell proliferation|
|positive regulation of chemotaxis|
|cellular response to transforming growth factor beta stimulus|
|response to transforming growth factor beta|
|growth factor activity|
|regulation of cell division|
|positive regulation of vasculature development|
|response to reactive oxygen species|
|regulation of leukocyte migration|
|cellular response to acid chemical|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of chemotaxis|
|cellular response to toxic substance|
|cellular response to oxidative stress|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of MAP kinase activity|
|regulation of ERK1 and ERK2 cascade|
|response to antibiotic|
|endoplasmic reticulum lumen|
|regulation of vasculature development|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|response to acid chemical|
|response to oxidative stress|
|cellular response to drug|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|response to toxic substance|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cell motility|
|response to growth factor|
|positive regulation of protein kinase activity|
|response to inorganic substance|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|positive regulation of locomotion|
|positive regulation of kinase activity|
|cellular response to organonitrogen compound|
|positive regulation of response to external stimulus|
|Golgi membrane|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|enzyme linked receptor protein signaling pathway|
|regulation of MAPK cascade|
|regulation of protein kinase activity|
|regulation of cell migration|
|regulation of kinase activity|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|regulation of response to external stimulus|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of immune system process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|regulation of immune system process|
|positive regulation of signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp218|A-395 10μM R05 exp218]]|-1.88|
|[[:results:exp340|BN82002 4μM R07 exp340]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13252
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDGFD Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>