======= PDGFRA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDGFRA
  * **<color #00a2e8>Official Name</color>**: platelet derived growth factor receptor alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5156|5156]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P16234|P16234]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDGFRA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDGFRA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/173490|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. {ECO:0000269|PubMed:10734113, ECO:0000269|PubMed:10947961, ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:12522257, ECO:0000269|PubMed:1646396, ECO:0000269|PubMed:1709159, ECO:0000269|PubMed:17141222, ECO:0000269|PubMed:20972453, ECO:0000269|PubMed:21224473, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664, ECO:0000269|PubMed:8760137, ECO:0000269|PubMed:8943348}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|I-set|
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|platelet-derived growth factor receptor-alpha signaling pathway|
|platelet-derived growth factor alpha-receptor activity|
|metanephric glomerulus vasculature morphogenesis|
|metanephric glomerulus morphogenesis|
|metanephric glomerular capillary formation|
|VEGF-activated platelet-derived growth factor receptor signaling pathway|
|positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway|
|glomerular capillary formation|
|glomerulus vasculature morphogenesis|
|regulation of mesenchymal stem cell differentiation|
|metanephric glomerulus vasculature development|
|renal system vasculature morphogenesis|
|vascular endothelial growth factor-activated receptor activity|
|vascular endothelial growth factor binding|
|kidney vasculature morphogenesis|
|luteinization|
|glomerulus morphogenesis|
|metanephric glomerulus development|
|Leydig cell differentiation|
|platelet-derived growth factor binding|
|platelet-derived growth factor receptor binding|
|retina vasculature development in camera-type eye|
|embryonic digestive tract morphogenesis|
|glomerulus vasculature development|
|negative regulation of platelet activation|
|vascular endothelial growth factor signaling pathway|
|kidney vasculature development|
|signal transduction involved in regulation of gene expression|
|renal system vasculature development|
|male genitalia development|
|cardiac myofibril assembly|
|adrenal gland development|
|regulation of platelet activation|
|metanephric nephron development|
|face morphogenesis|
|positive regulation of phosphatidylinositol 3-kinase activity|
|estrogen metabolic process|
|platelet-derived growth factor receptor signaling pathway|
|embryonic digestive tract development|
|positive regulation of lipid kinase activity|
|intrinsic component of plasma membrane|
|head morphogenesis|
|regulation of actin cytoskeleton reorganization|
|cellular response to vascular endothelial growth factor stimulus|
|positive regulation of phospholipase C activity|
|ovulation cycle process|
|platelet aggregation|
|body morphogenesis|
|embryonic cranial skeleton morphogenesis|
|regulation of phospholipase C activity|
|genitalia development|
|face development|
|positive regulation of phospholipid metabolic process|
|digestive tract morphogenesis|
|negative regulation of blood coagulation|
|positive regulation of fibroblast proliferation|
|glomerulus development|
|negative regulation of hemostasis|
|negative regulation of coagulation|
|regulation of phosphatidylinositol 3-kinase activity|
|transmembrane receptor protein tyrosine kinase activity|
|homotypic cell-cell adhesion|
|positive regulation of phospholipase activity|
|cardiac muscle cell development|
|regulation of lipid kinase activity|
|microvillus|
|cardiac cell development|
|myofibril assembly|
|cranial skeletal system development|
|ovulation cycle|
|cellular response to amino acid stimulus|
|regulation of phospholipase activity|
|positive regulation of lipase activity|
|phosphatidylinositol-mediated signaling|
|negative regulation of wound healing|
|inositol lipid-mediated signaling|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of fibroblast proliferation|
|regulation of coagulation|
|odontogenesis of dentin-containing tooth|
|metanephros development|
|regulation of phospholipid metabolic process|
|negative regulation of response to wounding|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|hematopoietic progenitor cell differentiation|
|cardiac muscle cell differentiation|
|female gonad development|
|roof of mouth development|
|development of primary female sexual characteristics|
|embryonic skeletal system morphogenesis|
|regulation of lipase activity|
|cellular component assembly involved in morphogenesis|
|female sex differentiation|
|response to amino acid|
|actomyosin structure organization|
|cardiocyte differentiation|
|regulation of stem cell differentiation|
|regulation of phosphatidylinositol 3-kinase signaling|
|odontogenesis|
|cellular hormone metabolic process|
|endocrine system development|
|nephron development|
|embryonic skeletal system development|
|digestive tract development|
|cellular response to reactive oxygen species|
|male gonad development|
|striated muscle cell development|
|development of primary male sexual characteristics|
|regulation of wound healing|
|platelet activation|
|retina development in camera-type eye|
|positive regulation of lipid metabolic process|
|digestive system development|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|muscle cell development|
|male sex differentiation|
|cardiac muscle tissue development|
|positive regulation of protein kinase B signaling|
|regulation of response to wounding|
|lung development|
|respiratory tube development|
|protein autophosphorylation|
|response to reactive oxygen species|
|respiratory system development|
|negative regulation of cell activation|
|cilium|
|striated muscle cell differentiation|
|hormone metabolic process|
|receptor complex|
|cellular response to acid chemical|
|cell chemotaxis|
|gonad development|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of chemotaxis|
|development of primary sexual characteristics|
|regulation of protein kinase B signaling|
|skeletal system morphogenesis|
|protein kinase activity|
|cellular response to oxidative stress|
|muscle cell differentiation|
|steroid metabolic process|
|sex differentiation|
|protein-containing complex binding|
|kidney development|
|rhythmic process|
|positive regulation of cytosolic calcium ion concentration|
|renal system development|
|striated muscle tissue development|
|embryonic organ morphogenesis|
|blood coagulation|
|regulation of ERK1 and ERK2 cascade|
|coagulation|
|muscle tissue development|
|hemostasis|
|camera-type eye development|
|angiogenesis|
|urogenital system development|
|regulation of cytosolic calcium ion concentration|
|extracellular matrix organization|
|regulation of actin cytoskeleton organization|
|response to acid chemical|
|eye development|
|visual system development|
|negative regulation of response to external stimulus|
|sensory system development|
|MAPK cascade|
|in utero embryonic development|
|extracellular structure organization|
|response to oxidative stress|
|regulation of actin filament-based process|
|signal transduction by protein phosphorylation|
|external side of plasma membrane|
|regulation of lipid metabolic process|
|blood vessel morphogenesis|
|gland development|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|supramolecular fiber organization|
|cellular divalent inorganic cation homeostasis|
|muscle structure development|
|wound healing|
|blood vessel development|
|divalent inorganic cation homeostasis|
|actin cytoskeleton organization|
|skeletal system development|
|regulation of body fluid levels|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|cell-cell adhesion|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|vasculature development|
|cardiovascular system development|
|positive regulation of cell motility|
|heart development|
|response to growth factor|
|regulation of hormone levels|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of MAPK cascade|
|sensory organ development|
|cell junction|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|cellular metal ion homeostasis|
|hemopoiesis|
|embryonic morphogenesis|
|actin filament-based process|
|response to wounding|
|positive regulation of kinase activity|
|protein-containing complex|
|cellular response to organonitrogen compound|
|hematopoietic or lymphoid organ development|
|metal ion homeostasis|
|chordate embryonic development|
|cellular cation homeostasis|
|regulation of cell activation|
|cellular ion homeostasis|
|immune system development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|developmental process involved in reproduction|
|viral process|
|cation homeostasis|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|organelle assembly|
|positive regulation of hydrolase activity|
|head development|
|symbiotic process|
|ion homeostasis|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|tube development|
|regulation of cell migration|
|circulatory system development|
|regulation of kinase activity|
|protein homodimerization activity|
|peptidyl-amino acid modification|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|cell migration|
|protein phosphorylation|
|regulation of transferase activity|
|embryo development|
|regulation of locomotion|
|Golgi apparatus|
|regulation of cellular component movement|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|cell activation|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|regulation of response to external stimulus|
|cytoskeleton organization|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|phosphorylation|
|regulation of organelle organization|
|locomotion|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|ATP binding|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.8|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.72|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|2.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|1/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15705
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDGFRA Expression in NALM6 Cells: 9.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>