======= PDGFRB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDGFRB
  * **<color #00a2e8>Official Name</color>**: platelet derived growth factor receptor beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5159|5159]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09619|P09619]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDGFRB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDGFRB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/173410|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the ETV6 gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Aug 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. {ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:11331881, ECO:0000269|PubMed:1314164, ECO:0000269|PubMed:1396585, ECO:0000269|PubMed:1653029, ECO:0000269|PubMed:1709159, ECO:0000269|PubMed:1846866, ECO:0000269|PubMed:20494825, ECO:0000269|PubMed:20529858, ECO:0000269|PubMed:21098708, ECO:0000269|PubMed:21679854, ECO:0000269|PubMed:21733313, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:26599395, ECO:0000269|PubMed:2835772, ECO:0000269|PubMed:2850496, ECO:0000269|PubMed:7685273, ECO:0000269|PubMed:7691811, ECO:0000269|PubMed:7692233, ECO:0000269|PubMed:8195171}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|I-set|
|Pkinase Tyr|
|ig|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|metanephric glomerular mesangial cell proliferation involved in metanephros development|
|metanephric mesenchymal cell migration|
|platelet-derived growth factor-activated receptor activity|
|cell migration involved in coronary angiogenesis|
|cell migration involved in metanephros development|
|cell migration involved in kidney development|
|glomerular mesangial cell proliferation|
|smooth muscle cell chemotaxis|
|platelet-derived growth factor beta-receptor activity|
|angiogenesis involved in coronary vascular morphogenesis|
|metanephric glomerular capillary formation|
|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|
|VEGF-activated platelet-derived growth factor receptor signaling pathway|
|cell migration involved in vasculogenesis|
|positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway|
|metanephric comma-shaped body morphogenesis|
|metanephric glomerulus vasculature morphogenesis|
|metanephric glomerular mesangium development|
|positive regulation of metanephric mesenchymal cell migration|
|metanephric glomerulus morphogenesis|
|regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|
|platelet activating factor receptor activity|
|regulation of metanephric mesenchymal cell migration|
|positive regulation of hepatic stellate cell activation|
|glomerular capillary formation|
|glomerulus vasculature morphogenesis|
|metanephric S-shaped body morphogenesis|
|comma-shaped body morphogenesis|
|regulation of hepatic stellate cell activation|
|metanephric glomerulus vasculature development|
|lung growth|
|kidney vasculature morphogenesis|
|cell proliferation involved in metanephros development|
|S-shaped body morphogenesis|
|renal system vasculature morphogenesis|
|platelet-derived growth factor receptor-beta signaling pathway|
|vascular endothelial growth factor binding|
|glomerulus morphogenesis|
|glomerular mesangium development|
|smooth muscle cell migration|
|cell proliferation involved in kidney development|
|metanephric glomerulus development|
|platelet-derived growth factor binding|
|positive regulation of metanephros development|
|metanephric mesenchyme development|
|cell migration involved in heart development|
|platelet-derived growth factor receptor binding|
|coronary vasculature morphogenesis|
|retina vasculature development in camera-type eye|
|glomerulus vasculature development|
|kidney mesenchyme development|
|kidney vasculature development|
|renal system vasculature development|
|cellular response to platelet-derived growth factor stimulus|
|metanephric nephron morphogenesis|
|positive regulation of calcium ion import|
|vascular endothelial growth factor signaling pathway|
|positive regulation of phosphoprotein phosphatase activity|
|phosphatidylinositol 3-kinase binding|
|response to hyperoxia|
|response to platelet-derived growth factor|
|muscle cell migration|
|regulation of metanephros development|
|cardiac myofibril assembly|
|positive regulation of collagen biosynthetic process|
|positive regulation of collagen metabolic process|
|metanephros morphogenesis|
|response to increased oxygen levels|
|aorta morphogenesis|
|positive regulation of Rho protein signal transduction|
|metanephric nephron development|
|positive regulation of phosphatidylinositol 3-kinase activity|
|platelet-derived growth factor receptor signaling pathway|
|positive regulation of phosphatase activity|
|response to fluid shear stress|
|regulation of collagen biosynthetic process|
|positive regulation of lipid kinase activity|
|positive regulation of smooth muscle cell migration|
|intrinsic component of plasma membrane|
|regulation of calcium ion import|
|regulation of collagen metabolic process|
|positive regulation of kidney development|
|cellular response to vascular endothelial growth factor stimulus|
|positive regulation of phospholipase C activity|
|positive regulation of protein dephosphorylation|
|coronary vasculature development|
|regulation of phospholipase C activity|
|positive regulation of phospholipid metabolic process|
|positive regulation of fibroblast proliferation|
|aorta development|
|glomerulus development|
|positive regulation of mitotic nuclear division|
|regulation of phosphatidylinositol 3-kinase activity|
|transmembrane receptor protein tyrosine kinase activity|
|regulation of kidney development|
|positive regulation of dephosphorylation|
|positive regulation of phospholipase activity|
|regulation of smooth muscle cell migration|
|cardiac muscle cell development|
|artery morphogenesis|
|regulation of lipid kinase activity|
|positive regulation of Ras protein signal transduction|
|cardiac cell development|
|myofibril assembly|
|positive regulation of nuclear division|
|positive regulation of DNA biosynthetic process|
|nephron morphogenesis|
|vasculogenesis|
|positive regulation of small GTPase mediated signal transduction|
|regulation of phospholipase activity|
|positive regulation of lipase activity|
|phosphatidylinositol-mediated signaling|
|inositol lipid-mediated signaling|
|response to estrogen|
|regulation of fibroblast proliferation|
|metanephros development|
|kidney morphogenesis|
|regulation of phospholipid metabolic process|
|artery development|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|positive regulation of smooth muscle cell proliferation|
|hematopoietic progenitor cell differentiation|
|cardiac muscle cell differentiation|
|protein tyrosine kinase activity|
|lysosomal lumen|
|positive regulation of reactive oxygen species metabolic process|
|organ growth|
|regulation of lipase activity|
|cellular component assembly involved in morphogenesis|
|glycosaminoglycan biosynthetic process|
|aminoglycan biosynthetic process|
|response to retinoic acid|
|regulation of DNA biosynthetic process|
|actomyosin structure organization|
|cardiocyte differentiation|
|regulation of phosphoprotein phosphatase activity|
|response to hydrogen peroxide|
|regulation of phosphatidylinositol 3-kinase signaling|
|positive regulation of calcium ion transport|
|nephron development|
|regulation of smooth muscle cell proliferation|
|male gonad development|
|development of primary male sexual characteristics|
|striated muscle cell development|
|response to estradiol|
|positive regulation of chemotaxis|
|retina development in camera-type eye|
|regulation of protein dephosphorylation|
|positive regulation of lipid metabolic process|
|regulation of Rho protein signal transduction|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|muscle cell development|
|positive regulation of mitotic cell cycle|
|glycosaminoglycan metabolic process|
|male sex differentiation|
|cardiac muscle tissue development|
|positive regulation of protein kinase B signaling|
|aminoglycan metabolic process|
|phosphatidylinositol metabolic process|
|regulation of mitotic nuclear division|
|lung development|
|respiratory tube development|
|regulation of phosphatase activity|
|regulation of reactive oxygen species metabolic process|
|regulation of nuclear division|
|positive regulation of DNA metabolic process|
|inner ear development|
|protein autophosphorylation|
|response to reactive oxygen species|
|respiratory system development|
|striated muscle cell differentiation|
|receptor complex|
|gonad development|
|cell chemotaxis|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of dephosphorylation|
|regulation of chemotaxis|
|development of primary sexual characteristics|
|regulation of protein kinase B signaling|
|mesenchyme development|
|ear development|
|connective tissue development|
|regulation of Ras protein signal transduction|
|muscle cell differentiation|
|regulation of calcium ion transport|
|cytoplasmic vesicle|
|positive regulation of MAP kinase activity|
|sex differentiation|
|kidney development|
|positive regulation of ion transport|
|aging|
|renal system development|
|striated muscle tissue development|
|positive regulation of cell cycle process|
|regulation of ERK1 and ERK2 cascade|
|muscle tissue development|
|response to antibiotic|
|glycerophospholipid metabolic process|
|camera-type eye development|
|angiogenesis|
|urogenital system development|
|apical plasma membrane|
|signaling receptor binding|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|regulation of actin cytoskeleton organization|
|response to acid chemical|
|regulation of small GTPase mediated signal transduction|
|enzyme binding|
|regulation of DNA metabolic process|
|eye development|
|visual system development|
|sensory system development|
|MAPK cascade|
|phospholipid metabolic process|
|positive regulation of cell cycle|
|glycerolipid metabolic process|
|response to oxygen levels|
|response to oxidative stress|
|regulation of metal ion transport|
|regulation of actin filament-based process|
|developmental growth|
|growth|
|signal transduction by protein phosphorylation|
|regulation of lipid metabolic process|
|blood vessel morphogenesis|
|focal adhesion|
|positive regulation of cell activation|
|reproductive structure development|
|reproductive system development|
|supramolecular fiber organization|
|protein kinase binding|
|muscle structure development|
|wound healing|
|blood vessel development|
|actin cytoskeleton organization|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|response to toxic substance|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|vasculature development|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|positive regulation of cell motility|
|heart development|
|response to growth factor|
|positive regulation of protein kinase activity|
|response to inorganic substance|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of MAPK cascade|
|sensory organ development|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|cell population proliferation|
|hemopoiesis|
|actin filament-based process|
|response to wounding|
|positive regulation of kinase activity|
|positive regulation of response to external stimulus|
|hematopoietic or lymphoid organ development|
|cell surface|
|carbohydrate derivative biosynthetic process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|immune system development|
|tube morphogenesis|
|positive regulation of transferase activity|
|developmental process involved in reproduction|
|intracellular membrane-bounded organelle|
|positive regulation of cell death|
|regulation of ion transport|
|enzyme linked receptor protein signaling pathway|
|regulation of MAPK cascade|
|regulation of cell cycle process|
|organelle assembly|
|positive regulation of hydrolase activity|
|regulation of protein kinase activity|
|cellular component morphogenesis|
|tube development|
|regulation of cell migration|
|response to lipid|
|circulatory system development|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|organophosphate metabolic process|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|response to hormone|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|cellular lipid metabolic process|
|animal organ morphogenesis|
|cell migration|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|Golgi apparatus|
|positive regulation of transport|
|negative regulation of cell death|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|carbohydrate derivative metabolic process|
|positive regulation of phosphorylation|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|cytoskeleton organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|response to abiotic stimulus|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|phosphorylation|
|regulation of organelle organization|
|locomotion|
|G protein-coupled receptor signaling pathway|
|positive regulation of developmental process|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|ATP binding|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-1.89|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6880
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDGFRB Expression in NALM6 Cells: 2.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>