======= PDK2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDK2
  * **<color #00a2e8>Official Name</color>**: pyruvate dehydrogenase kinase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5164|5164]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15119|Q15119]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDK2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDK2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602525|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis. {ECO:0000269|PubMed:17222789, ECO:0000269|PubMed:19833728, ECO:0000269|PubMed:21283817, ECO:0000269|PubMed:22123926, ECO:0000269|PubMed:7499431, ECO:0000269|PubMed:9787110}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HATPase c|
|BCDHK Adom3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial pyruvate dehydrogenase complex|
|pyruvate dehydrogenase (acetyl-transferring) kinase activity|
|regulation of acetyl-CoA biosynthetic process from pyruvate|
|regulation of acyl-CoA biosynthetic process|
|regulation of coenzyme metabolic process|
|regulation of sulfur metabolic process|
|regulation of cofactor metabolic process|
|regulation of purine nucleotide biosynthetic process|
|regulation of nucleotide biosynthetic process|
|regulation of gluconeogenesis|
|intrinsic apoptotic signaling pathway by p53 class mediator|
|cellular response to nutrient|
|regulation of fatty acid metabolic process|
|insulin receptor signaling pathway|
|regulation of carbohydrate biosynthetic process|
|regulation of calcium-mediated signaling|
|regulation of pH|
|regulation of glucose metabolic process|
|glucose metabolic process|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|signal transduction by p53 class mediator|
|cellular response to reactive oxygen species|
|regulation of cellular carbohydrate metabolic process|
|monovalent inorganic cation homeostasis|
|intrinsic apoptotic signaling pathway|
|hexose metabolic process|
|cellular response to insulin stimulus|
|regulation of cellular ketone metabolic process|
|glucose homeostasis|
|carbohydrate homeostasis|
|response to reactive oxygen species|
|monosaccharide metabolic process|
|regulation of carbohydrate metabolic process|
|response to nutrient|
|response to insulin|
|cellular response to nutrient levels|
|protein kinase activity|
|cellular response to oxidative stress|
|cellular response to extracellular stimulus|
|cellular response to peptide hormone stimulus|
|apoptotic signaling pathway|
|cellular response to peptide|
|cellular response to external stimulus|
|mitochondrial matrix|
|response to oxidative stress|
|response to peptide hormone|
|regulation of lipid metabolic process|
|regulation of cellular amide metabolic process|
|regulation of small molecule metabolic process|
|response to peptide|
|carbohydrate metabolic process|
|response to nutrient levels|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|response to extracellular stimulus|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|cation homeostasis|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|ion homeostasis|
|protein homodimerization activity|
|response to hormone|
|apoptotic process|
|protein phosphorylation|
|response to organonitrogen compound|
|programmed cell death|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|cell death|
|chemical homeostasis|
|cellular response to endogenous stimulus|
|mitochondrion|
|phosphorylation|
|response to endogenous stimulus|
|ATP binding|
|response to oxygen-containing compound|
|homeostatic process|
|intracellular signal transduction|
|cellular response to stress|
|small molecule metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7472
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDK2 Expression in NALM6 Cells: 2.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>