======= PDLIM5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDLIM5
  * **<color #00a2e8>Official Name</color>**: PDZ and LIM domain 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10611|10611]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96HC4|Q96HC4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDLIM5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDLIM5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605904|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LIM|
|PDZ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell growth involved in cardiac muscle cell development|
|physiological muscle hypertrophy|
|physiological cardiac muscle hypertrophy|
|actinin binding|
|cadherin binding involved in cell-cell adhesion|
|muscle alpha-actinin binding|
|cardiac muscle tissue growth|
|heart growth|
|cardiac muscle hypertrophy|
|striated muscle hypertrophy|
|muscle hypertrophy|
|filamentous actin|
|regulation of dendritic spine morphogenesis|
|protein kinase C binding|
|cardiac muscle cell development|
|cardiac cell development|
|stress fiber|
|regulation of dendritic spine development|
|developmental cell growth|
|cardiac muscle cell differentiation|
|cell growth|
|regulation of dendrite morphogenesis|
|regulation of postsynapse organization|
|organ growth|
|regulation of synapse assembly|
|cell-cell adherens junction|
|protein N-terminus binding|
|cardiocyte differentiation|
|Z disc|
|striated muscle cell development|
|muscle cell development|
|regulation of dendrite development|
|cardiac muscle tissue development|
|postsynaptic membrane|
|striated muscle cell differentiation|
|actin cytoskeleton|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|muscle cell differentiation|
|postsynaptic density|
|actin binding|
|striated muscle tissue development|
|muscle tissue development|
|muscle system process|
|regulation of cell morphogenesis involved in differentiation|
|neuron projection|
|developmental growth|
|growth|
|muscle structure development|
|regulation of cell morphogenesis|
|actin cytoskeleton organization|
|regulation of neuron projection development|
|cell-cell adhesion|
|heart development|
|actin filament-based process|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of neurogenesis|
|circulatory system development|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|regulation of cellular component biogenesis|
|regulation of anatomical structure morphogenesis|
|cytoskeleton organization|
|generation of neurons|
|neurogenesis|
|cell development|
|tissue development|
|regulation of cell differentiation|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13138
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDLIM5 Expression in NALM6 Cells: 4.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>