======= PDP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDP2
  * **<color #00a2e8>Official Name</color>**: pyruvate dehyrogenase phosphatase catalytic subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57546|57546]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P2J9|Q9P2J9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615499|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a mitochondrial protein that functions as a phosphatase and is involved in the enzymatic resetting of the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PP2C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|[pyruvate dehydrogenase (lipoamide)] phosphatase activity|
|positive regulation of pyruvate dehydrogenase activity|
|regulation of pyruvate dehydrogenase activity|
|regulation of acetyl-CoA biosynthetic process from pyruvate|
|regulation of acyl-CoA biosynthetic process|
|regulation of coenzyme metabolic process|
|regulation of sulfur metabolic process|
|magnesium-dependent protein serine/threonine phosphatase activity|
|regulation of cofactor metabolic process|
|regulation of purine nucleotide biosynthetic process|
|regulation of nucleotide biosynthetic process|
|positive regulation of oxidoreductase activity|
|protein serine/threonine phosphatase activity|
|regulation of fatty acid metabolic process|
|regulation of oxidoreductase activity|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of cellular ketone metabolic process|
|protein dephosphorylation|
|dephosphorylation|
|mitochondrial matrix|
|regulation of lipid metabolic process|
|regulation of cellular amide metabolic process|
|regulation of small molecule metabolic process|
|mitochondrion|
|positive regulation of catalytic activity|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|1.72|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|1.76|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|1.8|
|[[:results:exp148|SB202190 10μM R03 exp148]]|1.83|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.91|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.93|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mdh1|MDH1]]|0.458|
|[[:human genes:p:pdhb|PDHB]]|0.422|
|[[:human genes:p:pdha1|PDHA1]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9753
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDP2 Expression in NALM6 Cells: 6.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>