======= PDPN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDPN
  * **<color #00a2e8>Official Name</color>**: podoplanin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10630|10630]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86YL7|Q86YL7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDPN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDPN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608863|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activation and/or aggregation (PubMed:14522983, PubMed:15231832, PubMed:17616532, PubMed:18215137, PubMed:17222411). Interaction with CD9, on the contrary, attenuates platelet aggregation induced by PDPN (PubMed:18541721). Through MSN or EZR interaction promotes epithelial-mesenchymal transition (EMT) leading to ERZ phosphorylation and triggering RHOA activation leading to cell migration increase and invasiveness (PubMed:17046996, PubMed:21376833). Interaction with CD44 promotes directional cell migration in epithelial and tumor cells (PubMed:20962267). In lymph nodes (LNs), controls fibroblastic reticular cells (FRCs) adhesion to the extracellular matrix (ECM) and contraction of the actomyosin by maintaining ERM proteins (EZR; MSN and RDX) and MYL9 activation through association with unknown transmembrane proteins. Engagement of CLEC1B by PDPN promotes FRCs relaxation by blocking lateral membrane interactions leading to reduction of ERM proteins (EZR; MSN and RDX) and MYL9 activation (By similarity). Through binding with LGALS8 may participate to connection of the lymphatic endothelium to the surrounding extracellular matrix (PubMed:19268462). In keratinocytes, induces changes in cell morphology showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion (PubMed:15515019). Controls invadopodia stability and maturation leading to efficient degradation of the extracellular matrix (ECM) in tumor cells through modulation of RHOC activity in order to activate ROCK1/ROCK2 and LIMK1/LIMK2 and inactivation of CFL1 (PubMed:25486435). Required for normal lung cell proliferation and alveolus formation at birth (By similarity). Does not function as a water channel or as a regulator of aquaporin-type water channels (PubMed:9651190). Does not have any effect on folic acid or amino acid transport (By similarity). {ECO:0000250|UniProtKB:Q62011, ECO:0000269|PubMed:14522983, ECO:0000269|PubMed:15231832, ECO:0000269|PubMed:15515019, ECO:0000269|PubMed:17046996, ECO:0000269|PubMed:17222411, ECO:0000269|PubMed:17616532, ECO:0000269|PubMed:18215137, ECO:0000269|PubMed:18541721, ECO:0000269|PubMed:19268462, ECO:0000269|PubMed:20962267, ECO:0000269|PubMed:21376833, ECO:0000269|PubMed:25486435, ECO:0000269|PubMed:9651190}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Podoplanin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of myofibroblast contraction|
|invadopodium organization|
|leading edge of lamellipodium|
|positive regulation of platelet aggregation|
|lymphatic endothelial cell fate commitment|
|positive regulation of platelet activation|
|folic acid transmembrane transporter activity|
|water transmembrane transporter activity|
|positive regulation of homotypic cell-cell adhesion|
|endothelial cell fate commitment|
|lymphatic endothelial cell differentiation|
|positive regulation of extracellular matrix disassembly|
|folic acid transport|
|invadopodium|
|tetraspanin-enriched microdomain|
|regulation of lamellipodium morphogenesis|
|water channel activity|
|lymphangiogenesis|
|epithelial cell fate commitment|
|lymph vessel morphogenesis|
|regulation of extracellular matrix disassembly|
|lymph node development|
|filopodium membrane|
|regulation of platelet aggregation|
|water transport|
|positive regulation of extracellular matrix organization|
|lymph vessel development|
|lamellipodium membrane|
|microvillus membrane|
|chemokine binding|
|modified amino acid transport|
|epiboly involved in wound healing|
|wound healing, spreading of cells|
|regulation of homotypic cell-cell adhesion|
|epiboly|
|positive regulation of blood coagulation|
|positive regulation of hemostasis|
|positive regulation of coagulation|
|fluid transport|
|regulation of platelet activation|
|amino acid transmembrane transporter activity|
|regulation of extracellular matrix organization|
|vitamin transport|
|regulation of lamellipodium organization|
|regulation of actin filament-based movement|
|cofactor transport|
|positive regulation of epithelial to mesenchymal transition|
|morphogenesis of an epithelial sheet|
|regulation of substrate adhesion-dependent cell spreading|
|positive regulation of wound healing|
|positive regulation of response to wounding|
|filopodium|
|amino acid transmembrane transport|
|Rho protein signal transduction|
|dicarboxylic acid transport|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of coagulation|
|endothelial cell differentiation|
|regulation of epithelial to mesenchymal transition|
|actin-mediated cell contraction|
|ruffle|
|ruffle membrane|
|endothelium development|
|cell projection|
|chaperone binding|
|actin filament-based movement|
|amino acid transport|
|carboxylic acid transmembrane transport|
|organic acid transmembrane transport|
|regulation of wound healing|
|platelet activation|
|drug transport|
|regulation of cell shape|
|regulation of response to wounding|
|lung development|
|respiratory tube development|
|lamellipodium|
|respiratory system development|
|basolateral plasma membrane|
|regulation of cell-substrate adhesion|
|membrane raft|
|cell fate commitment|
|Ras protein signal transduction|
|cytoplasmic vesicle|
|positive regulation of cell-cell adhesion|
|anion transmembrane transport|
|organic acid transport|
|carboxylic acid transport|
|blood coagulation|
|coagulation|
|hemostasis|
|regulation of cell morphogenesis involved in differentiation|
|apical plasma membrane|
|small GTPase mediated signal transduction|
|signaling receptor binding|
|regulation of actin filament-based process|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|morphogenesis of an epithelium|
|organic anion transport|
|wound healing|
|regulation of cell morphogenesis|
|regulation of body fluid levels|
|positive regulation of cell migration|
|vasculature development|
|cardiovascular system development|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|cell junction|
|positive regulation of locomotion|
|tissue morphogenesis|
|actin filament-based process|
|response to wounding|
|anion transport|
|hematopoietic or lymphoid organ development|
|regulation of cell activation|
|immune system development|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|cell morphogenesis|
|cellular component morphogenesis|
|tube development|
|regulation of cell migration|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|regulation of cell development|
|ion transmembrane transport|
|cell migration|
|positive regulation of cell differentiation|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cell death|
|response to drug|
|regulation of anatomical structure morphogenesis|
|cell activation|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|transmembrane transport|
|locomotion|
|positive regulation of developmental process|
|ion transport|
|integral component of plasma membrane|
|regulation of response to stress|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|amide transport|
|regulation of cell population proliferation|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17977
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDPN Expression in NALM6 Cells: 0.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>