======= PDSS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDSS2
  * **<color #00a2e8>Official Name</color>**: decaprenyl diphosphate synthase subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57107|57107]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86YH6|Q86YH6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDSS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDSS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610564|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an enzyme that synthesizes the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. Defects in this gene are a cause of coenzyme Q10 deficiency.[provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10. {ECO:0000269|PubMed:16262699}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|polyprenyl synt|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|trans-hexaprenyltranstransferase activity|
|trans-octaprenyltranstransferase activity|
|transferase complex|
|quinone biosynthetic process|
|ubiquinone biosynthetic process|
|ubiquinone metabolic process|
|ketone biosynthetic process|
|isoprenoid biosynthetic process|
|quinone metabolic process|
|protein heterotetramerization|
|oxidoreduction coenzyme metabolic process|
|cellular ketone metabolic process|
|protein heterooligomerization|
|coenzyme biosynthetic process|
|isoprenoid metabolic process|
|protein tetramerization|
|cofactor biosynthetic process|
|coenzyme metabolic process|
|mitochondrial matrix|
|cofactor metabolic process|
|protein heterodimerization activity|
|regulation of body fluid levels|
|protein complex oligomerization|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|cellular lipid metabolic process|
|lipid metabolic process|
|protein-containing complex assembly|
|small molecule metabolic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-1.76|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.72|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.72|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.78|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.84|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.92|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.07|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|2.34|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.35|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|3.54|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:coq2|COQ2]]|0.493|
|[[:human genes:c:coq4|COQ4]]|0.466|
|[[:human genes:p:pet117|PET117]]|0.461|
|[[:human genes:q:qrsl1|QRSL1]]|0.46|
|[[:human genes:d:dap3|DAP3]]|0.446|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.432|
|[[:human genes:n:ndufb9|NDUFB9]]|0.42|
|[[:human genes:n:ndufa1|NDUFA1]]|0.418|
|[[:human genes:m:mettl17|METTL17]]|0.416|
|[[:human genes:n:ndufb11|NDUFB11]]|0.415|
|[[:human genes:m:mrpl39|MRPL39]]|0.415|
|[[:human genes:m:mcat|MCAT]]|0.414|
|[[:human genes:e:eral1|ERAL1]]|0.413|
|[[:human genes:m:mrpl47|MRPL47]]|0.412|
|[[:human genes:n:nars2|NARS2]]|0.409|
|[[:human genes:g:grsf1|GRSF1]]|0.408|
|[[:human genes:e:ears2|EARS2]]|0.405|
|[[:human genes:s:sfxn4|SFXN4]]|0.401|
|[[:human genes:p:pdss1|PDSS1]]|0.401|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 922
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDSS2 Expression in NALM6 Cells: 4.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>