======= PELO =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PELO
  * **<color #00a2e8>Official Name</color>**: pelota mRNA surveillance and ribosome rescue factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=53918|53918]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BRX2|Q9BRX2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PELO&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PELO|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605757|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential). {ECO:0000250, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|eRF1 1|
|eRF1 2|
|eRF1 3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nonfunctional rRNA decay|
|nuclear-transcribed mRNA catabolic process, non-stop decay|
|nuclear-transcribed mRNA catabolic process, no-go decay|
|ribosome disassembly|
|inner cell mass cell proliferation|
|ribonucleoprotein complex disassembly|
|mesenchymal to epithelial transition|
|RNA surveillance|
|blastocyst growth|
|rRNA catabolic process|
|ncRNA catabolic process|
|positive regulation of BMP signaling pathway|
|endonuclease activity|
|ribosome binding|
|organelle disassembly|
|endoderm development|
|regulation of BMP signaling pathway|
|blastocyst development|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|stem cell population maintenance|
|maintenance of cell number|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|rRNA metabolic process|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|protein-containing complex disassembly|
|ribonucleoprotein complex subunit organization|
|RNA catabolic process|
|regulation of cellular response to growth factor stimulus|
|nucleic acid phosphodiester bond hydrolysis|
|nucleobase-containing compound catabolic process|
|in utero embryonic development|
|developmental growth|
|growth|
|cellular component disassembly|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ncRNA metabolic process|
|organic cyclic compound catabolic process|
|cell division|
|cell population proliferation|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|epithelial cell differentiation|
|mRNA metabolic process|
|cellular macromolecule catabolic process|
|embryo development|
|macromolecule catabolic process|
|chromosome organization|
|epithelium development|
|cell cycle|
|positive regulation of signal transduction|
|RNA metabolic process|
|negative regulation of gene expression|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-1.89|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.79|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.88|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.89|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.97|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.98|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.02|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|2.05|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|2.05|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.08|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.25|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|2.33|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.39|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.54|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.71|
|[[:results:exp539|42°C R08 exp539]]|2.72|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.81|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.81|
|[[:results:exp17|DABN 20μM R00 exp17]]|2.91|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|3|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|3.1|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|3.34|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|3.35|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|3.46|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|3.48|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.652|
|[[:human genes:m:med16|MED16]]|0.643|
|[[:human genes:r:rptor|RPTOR]]|0.64|
|[[:human genes:t:thg1l|THG1L]]|0.634|
|[[:human genes:a:alg1|ALG1]]|0.62|
|[[:human genes:p:pmm2|PMM2]]|0.607|
|[[:human genes:g:gmppb|GMPPB]]|0.604|
|[[:human genes:r:rnmt|RNMT]]|0.597|
|[[:human genes:t:triap1|TRIAP1]]|0.582|
|[[:human genes:d:dpagt1|DPAGT1]]|0.58|
|[[:human genes:a:aars|AARS]]|0.58|
|[[:human genes:b:bub3|BUB3]]|0.579|
|[[:human genes:t:tsen54|TSEN54]]|0.571|
|[[:human genes:c:ccdc101|CCDC101]]|0.569|
|[[:human genes:e:eif4e|EIF4E]]|0.565|
|[[:human genes:m:mtor|MTOR]]|0.564|
|[[:human genes:r:rtcb|RTCB]]|0.561|
|[[:human genes:g:gfpt1|GFPT1]]|0.557|
|[[:human genes:p:pam16|PAM16]]|0.556|
|[[:human genes:u:utp23|UTP23]]|0.555|
|[[:human genes:u:uap1|UAP1]]|0.547|
|[[:human genes:a:alg2|ALG2]]|0.545|
|[[:human genes:t:tti2|TTI2]]|0.544|
|[[:human genes:d:dohh|DOHH]]|0.544|
|[[:human genes:d:dhps|DHPS]]|0.534|
|[[:human genes:r:rbm14|RBM14]]|0.532|
|[[:human genes:a:atxn10|ATXN10]]|0.531|
|[[:human genes:m:meaf6|MEAF6]]|0.53|
|[[:human genes:e:exoc3|EXOC3]]|0.53|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.529|
|[[:human genes:y:yars|YARS]]|0.528|
|[[:human genes:o:oraov1|ORAOV1]]|0.526|
|[[:human genes:f:fnta|FNTA]]|0.521|
|[[:human genes:t:tmem41b|TMEM41B]]|0.52|
|[[:human genes:d:dad1|DAD1]]|0.519|
|[[:human genes:u:uhrf1|UHRF1]]|0.517|
|[[:human genes:w:wdr24|WDR24]]|0.517|
|[[:human genes:w:wdr59|WDR59]]|0.516|
|[[:human genes:t:tsen34|TSEN34]]|0.505|
|[[:human genes:t:tgs1|TGS1]]|0.504|
|[[:human genes:v:vezt|VEZT]]|0.503|
|[[:human genes:n:nae1|NAE1]]|0.501|
|[[:human genes:d:ddx20|DDX20]]|0.5|
|[[:human genes:t:trmt5|TRMT5]]|0.5|
|[[:human genes:e:eprs|EPRS]]|0.5|
|[[:human genes:m:mllt1|MLLT1]]|0.499|
|[[:human genes:s:srp14|SRP14]]|0.499|
|[[:human genes:a:adsl|ADSL]]|0.499|
|[[:human genes:h:hspd1|HSPD1]]|0.498|
|[[:human genes:g:gnb1l|GNB1L]]|0.498|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.496|
|[[:human genes:a:alg13|ALG13]]|0.49|
|[[:human genes:v:vhl|VHL]]|0.49|
|[[:human genes:m:med23|MED23]]|0.49|
|[[:human genes:t:tle4|TLE4]]|0.488|
|[[:human genes:d:ddost|DDOST]]|0.487|
|[[:human genes:r:rpp21|RPP21]]|0.484|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.481|
|[[:human genes:t:tti1|TTI1]]|0.481|
|[[:human genes:e:eny2|ENY2]]|0.479|
|[[:human genes:n:nars|NARS]]|0.478|
|[[:human genes:m:mad2l1|MAD2L1]]|0.478|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.476|
|[[:human genes:t:thoc6|THOC6]]|0.475|
|[[:human genes:h:hccs|HCCS]]|0.473|
|[[:human genes:a:alg14|ALG14]]|0.473|
|[[:human genes:d:dpf2|DPF2]]|0.473|
|[[:human genes:c:cbfb|CBFB]]|0.472|
|[[:human genes:s:spcs2|SPCS2]]|0.471|
|[[:human genes:m:mars|MARS]]|0.467|
|[[:human genes:p:plaa|PLAA]]|0.466|
|[[:human genes:t:ten1|TEN1]]|0.464|
|[[:human genes:d:dr1|DR1]]|0.463|
|[[:human genes:t:trnt1|TRNT1]]|0.463|
|[[:human genes:t:tbca|TBCA]]|0.461|
|[[:human genes:l:lsm11|LSM11]]|0.458|
|[[:human genes:s:slc25a19|SLC25A19]]|0.458|
|[[:human genes:g:gemin5|GEMIN5]]|0.457|
|[[:human genes:p:polr3h|POLR3H]]|0.457|
|[[:human genes:t:tamm41|TAMM41]]|0.456|
|[[:human genes:m:med4|MED4]]|0.454|
|[[:human genes:s:srp72|SRP72]]|0.453|
|[[:human genes:s:seh1l|SEH1L]]|0.453|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.451|
|[[:human genes:p:phb|PHB]]|0.45|
|[[:human genes:s:spcs3|SPCS3]]|0.45|
|[[:human genes:p:pdap1|PDAP1]]|0.45|
|[[:human genes:r:rpe|RPE]]|0.45|
|[[:human genes:a:alg5|ALG5]]|0.448|
|[[:human genes:s:sdha|SDHA]]|0.448|
|[[:human genes:g:gemin8|GEMIN8]]|0.446|
|[[:human genes:k:kntc1|KNTC1]]|0.446|
|[[:human genes:t:txnrd1|TXNRD1]]|0.445|
|[[:human genes:n:nhlrc2|NHLRC2]]|0.444|
|[[:human genes:w:wdr82|WDR82]]|0.443|
|[[:human genes:v:vmp1|VMP1]]|0.443|
|[[:human genes:r:rpn1|RPN1]]|0.442|
|[[:human genes:e:exoc4|EXOC4]]|0.442|
|[[:human genes:h:haus8|HAUS8]]|0.44|
|[[:human genes:t:tmed10|TMED10]]|0.439|
|[[:human genes:c:cct7|CCT7]]|0.438|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.438|
|[[:human genes:d:ddx39a|DDX39A]]|0.437|
|[[:human genes:b:bap1|BAP1]]|0.435|
|[[:human genes:o:oip5|OIP5]]|0.435|
|[[:human genes:o:osgep|OSGEP]]|0.433|
|[[:human genes:m:mad1l1|MAD1L1]]|0.432|
|[[:human genes:z:znf259|ZNF259]]|0.431|
|[[:human genes:f:faf2|FAF2]]|0.428|
|[[:human genes:d:dicer1|DICER1]]|0.427|
|[[:human genes:a:abcf1|ABCF1]]|0.424|
|[[:human genes:c:cars|CARS]]|0.424|
|[[:human genes:d:dhdds|DHDDS]]|0.423|
|[[:human genes:a:atp5j|ATP5J]]|0.423|
|[[:human genes:s:slc35b1|SLC35B1]]|0.422|
|[[:human genes:e:eif3f|EIF3F]]|0.421|
|[[:human genes:a:atp5o|ATP5O]]|0.42|
|[[:human genes:l:lsmd1|LSMD1]]|0.419|
|[[:human genes:p:polr3b|POLR3B]]|0.419|
|[[:human genes:k:kctd5|KCTD5]]|0.418|
|[[:human genes:n:nsmce1|NSMCE1]]|0.418|
|[[:human genes:l:lsm10|LSM10]]|0.418|
|[[:human genes:g:gtf3a|GTF3A]]|0.418|
|[[:human genes:p:ppcs|PPCS]]|0.417|
|[[:human genes:p:ppp4c|PPP4C]]|0.417|
|[[:human genes:t:telo2|TELO2]]|0.416|
|[[:human genes:r:romo1|ROMO1]]|0.415|
|[[:human genes:a:apaf1|APAF1]]|0.414|
|[[:human genes:m:max|MAX]]|0.414|
|[[:human genes:g:gemin6|GEMIN6]]|0.414|
|[[:human genes:a:actr10|ACTR10]]|0.413|
|[[:human genes:c:crcp|CRCP]]|0.413|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.412|
|[[:human genes:c:cep350|CEP350]]|0.412|
|[[:human genes:p:pyroxd1|PYROXD1]]|0.411|
|[[:human genes:e:eef1e1|EEF1E1]]|0.411|
|[[:human genes:u:ube2g2|UBE2G2]]|0.41|
|[[:human genes:p:ppp6c|PPP6C]]|0.409|
|[[:human genes:c:casp9|CASP9]]|0.409|
|[[:human genes:t:taz|TAZ]]|0.409|
|[[:human genes:a:atp5h|ATP5H]]|0.407|
|[[:human genes:c:chchd4|CHCHD4]]|0.407|
|[[:human genes:d:dolk|DOLK]]|0.406|
|[[:human genes:d:ddx1|DDX1]]|0.406|
|[[:human genes:s:sec62|SEC62]]|0.406|
|[[:human genes:c:csnk2b|CSNK2B]]|0.405|
|[[:human genes:m:mapk14|MAPK14]]|0.405|
|[[:human genes:b:bub1b|BUB1B]]|0.405|
|[[:human genes:d:dctn6|DCTN6]]|0.405|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.403|
|[[:human genes:g:gabpa|GABPA]]|0.402|
|[[:human genes:p:pik3r4|PIK3R4]]|0.402|
|[[:human genes:p:pggt1b|PGGT1B]]|0.401|
|[[:human genes:l:lmo2|LMO2]]|0.401|
|[[:human genes:u:uba3|UBA3]]|0.401|
|[[:human genes:p:pisd|PISD]]|0.401|
|[[:human genes:n:nup50|NUP50]]|0.4|
|[[:human genes:r:rad1|RAD1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 436/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|17/28|
|blood|13/28|
|bone|19/26|
|breast|14/33|
|central nervous system|25/56|
|cervix|3/4|
|colorectal|8/17|
|esophagus|10/13|
|fibroblast|0/1|
|gastric|11/16|
|kidney|10/21|
|liver|10/20|
|lung|56/75|
|lymphocyte|11/16|
|ovary|12/26|
|pancreas|13/24|
|peripheral nervous system|8/16|
|plasma cell|5/15|
|prostate|0/1|
|skin|13/24|
|soft tissue|4/9|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|20/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 139
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.5 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PELO Expression in NALM6 Cells: 3.5'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>