======= PET112 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GATB
  * **<color #00a2e8>Official Name</color>**: glutamyl-tRNA amidotransferase subunit B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5188|5188]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75879|O75879]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PET112&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PET112|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603645|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). {ECO:0000255|HAMAP-Rule:MF_03147, ECO:0000269|PubMed:19805282}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GatB Yqey|
|GatB N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glutamyl-tRNA(Gln) amidotransferase complex|
|glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity|
|glutaminyl-tRNAGln biosynthesis via transamidation|
|tRNA aminoacylation|
|amino acid activation|
|mitochondrial translation|
|mitochondrial gene expression|
|tRNA metabolic process|
|cellular amino acid metabolic process|
|translation|
|peptide biosynthetic process|
|ncRNA metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.74|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.74|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.79|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.8|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|1.81|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.9|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.9|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.93|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.95|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|2.18|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.27|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:q:qrsl1|QRSL1]]|0.719|
|[[:human genes:n:nars2|NARS2]]|0.71|
|[[:human genes:e:ears2|EARS2]]|0.659|
|[[:human genes:p:pet117|PET117]]|0.649|
|[[:human genes:y:yars2|YARS2]]|0.643|
|[[:human genes:f:ftsj2|FTSJ2]]|0.641|
|[[:human genes:c:coa3|COA3]]|0.639|
|[[:human genes:s:selrc1|SELRC1]]|0.638|
|[[:human genes:l:lars2|LARS2]]|0.63|
|[[:human genes:m:mrps21|MRPS21]]|0.627|
|[[:human genes:d:dap3|DAP3]]|0.624|
|[[:human genes:m:mettl17|METTL17]]|0.623|
|[[:human genes:m:mrps16|MRPS16]]|0.619|
|[[:human genes:d:ddx28|DDX28]]|0.619|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.616|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.614|
|[[:human genes:s:sco2|SCO2]]|0.612|
|[[:human genes:a:aars2|AARS2]]|0.61|
|[[:human genes:p:pars2|PARS2]]|0.609|
|[[:human genes:t:tars2|TARS2]]|0.606|
|[[:human genes:r:rars2|RARS2]]|0.602|
|[[:human genes:m:mrpl21|MRPL21]]|0.601|
|[[:human genes:w:wars2|WARS2]]|0.6|
|[[:human genes:f:fastkd5|FASTKD5]]|0.599|
|[[:human genes:m:mtg1|MTG1]]|0.596|
|[[:human genes:m:mrpl23|MRPL23]]|0.593|
|[[:human genes:v:vars2|VARS2]]|0.592|
|[[:human genes:m:mrpl45|MRPL45]]|0.592|
|[[:human genes:m:mrps12|MRPS12]]|0.59|
|[[:human genes:r:rpusd3|RPUSD3]]|0.587|
|[[:human genes:m:mrps6|MRPS6]]|0.587|
|[[:human genes:m:mrpl47|MRPL47]]|0.586|
|[[:human genes:n:nsun4|NSUN4]]|0.583|
|[[:human genes:g:gfm2|GFM2]]|0.583|
|[[:human genes:m:mrps34|MRPS34]]|0.582|
|[[:human genes:r:rpusd4|RPUSD4]]|0.581|
|[[:human genes:n:ndufb11|NDUFB11]]|0.579|
|[[:human genes:a:acad9|ACAD9]]|0.575|
|[[:human genes:r:rbfa|RBFA]]|0.575|
|[[:human genes:m:mrps10|MRPS10]]|0.575|
|[[:human genes:m:mrps27|MRPS27]]|0.572|
|[[:human genes:m:mrpl53|MRPL53]]|0.571|
|[[:human genes:e:eral1|ERAL1]]|0.57|
|[[:human genes:c:coa6|COA6]]|0.569|
|[[:human genes:h:hars2|HARS2]]|0.569|
|[[:human genes:c:cox11|COX11]]|0.569|
|[[:human genes:m:mtg2|MTG2]]|0.567|
|[[:human genes:m:mrps25|MRPS25]]|0.567|
|[[:human genes:m:mrps35|MRPS35]]|0.566|
|[[:human genes:m:mrpl4|MRPL4]]|0.565|
|[[:human genes:p:polg2|POLG2]]|0.562|
|[[:human genes:m:malsu1|MALSU1]]|0.562|
|[[:human genes:t:tfb1m|TFB1M]]|0.562|
|[[:human genes:m:mars2|MARS2]]|0.561|
|[[:human genes:m:mtif2|MTIF2]]|0.56|
|[[:human genes:c:cars2|CARS2]]|0.56|
|[[:human genes:m:mterfd1|MTERFD1]]|0.559|
|[[:human genes:m:mrps26|MRPS26]]|0.556|
|[[:human genes:t:tefm|TEFM]]|0.549|
|[[:human genes:n:ndufa2|NDUFA2]]|0.549|
|[[:human genes:g:gfm1|GFM1]]|0.548|
|[[:human genes:c:cox20|COX20]]|0.547|
|[[:human genes:n:ndufa3|NDUFA3]]|0.546|
|[[:human genes:f:fastkd2|FASTKD2]]|0.545|
|[[:human genes:n:nubpl|NUBPL]]|0.543|
|[[:human genes:d:dars2|DARS2]]|0.542|
|[[:human genes:m:mrps5|MRPS5]]|0.542|
|[[:human genes:m:mrps14|MRPS14]]|0.542|
|[[:human genes:c:cox15|COX15]]|0.541|
|[[:human genes:w:wbscr16|WBSCR16]]|0.541|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.54|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.54|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.533|
|[[:human genes:m:mrps18a|MRPS18A]]|0.533|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.529|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.529|
|[[:human genes:n:ndufa11|NDUFA11]]|0.527|
|[[:human genes:m:mrpl3|MRPL3]]|0.525|
|[[:human genes:m:mrpl43|MRPL43]]|0.523|
|[[:human genes:m:mrpl12|MRPL12]]|0.522|
|[[:human genes:m:mto1|MTO1]]|0.522|
|[[:human genes:n:ndufs2|NDUFS2]]|0.521|
|[[:human genes:n:ndufa1|NDUFA1]]|0.52|
|[[:human genes:m:mrp63|MRP63]]|0.516|
|[[:human genes:t:trub2|TRUB2]]|0.515|
|[[:human genes:g:grsf1|GRSF1]]|0.515|
|[[:human genes:m:mrpl49|MRPL49]]|0.511|
|[[:human genes:m:mrpl20|MRPL20]]|0.506|
|[[:human genes:g:gatc|GATC]]|0.506|
|[[:human genes:a:atp5sl|ATP5SL]]|0.506|
|[[:human genes:c:c10orf2|C10orf2]]|0.506|
|[[:human genes:m:mcat|MCAT]]|0.504|
|[[:human genes:i:ict1|ICT1]]|0.504|
|[[:human genes:m:mrps22|MRPS22]]|0.504|
|[[:human genes:c:cox16|COX16]]|0.503|
|[[:human genes:p:polg|POLG]]|0.503|
|[[:human genes:c:c12orf65|C12orf65]]|0.502|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.499|
|[[:human genes:c:clpp|CLPP]]|0.496|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.496|
|[[:human genes:f:fars2|FARS2]]|0.495|
|[[:human genes:n:ndufv1|NDUFV1]]|0.494|
|[[:human genes:m:mrpl17|MRPL17]]|0.494|
|[[:human genes:m:mrpl13|MRPL13]]|0.494|
|[[:human genes:i:iba57|IBA57]]|0.493|
|[[:human genes:m:mrpl1|MRPL1]]|0.493|
|[[:human genes:t:tomm20|TOMM20]]|0.491|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.491|
|[[:human genes:n:ndufb9|NDUFB9]]|0.487|
|[[:human genes:m:mrpl18|MRPL18]]|0.483|
|[[:human genes:n:ndufc2|NDUFC2]]|0.481|
|[[:human genes:c:chchd1|CHCHD1]]|0.481|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.479|
|[[:human genes:m:mipep|MIPEP]]|0.478|
|[[:human genes:m:mterfd2|MTERFD2]]|0.478|
|[[:human genes:m:mrpl42|MRPL42]]|0.477|
|[[:human genes:c:c1qbp|C1QBP]]|0.476|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.476|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.473|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.473|
|[[:human genes:m:mrps24|MRPS24]]|0.471|
|[[:human genes:p:pnpt1|PNPT1]]|0.471|
|[[:human genes:p:polrmt|POLRMT]]|0.469|
|[[:human genes:s:ssbp1|SSBP1]]|0.469|
|[[:human genes:m:mrpl33|MRPL33]]|0.468|
|[[:human genes:m:mrpl15|MRPL15]]|0.466|
|[[:human genes:m:mrps7|MRPS7]]|0.465|
|[[:human genes:m:mrpl2|MRPL2]]|0.464|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.464|
|[[:human genes:p:pitrm1|PITRM1]]|0.459|
|[[:human genes:c:coq7|COQ7]]|0.458|
|[[:human genes:t:tsfm|TSFM]]|0.458|
|[[:human genes:l:lrpprc|LRPPRC]]|0.458|
|[[:human genes:p:ptcd3|PTCD3]]|0.457|
|[[:human genes:s:sars2|SARS2]]|0.454|
|[[:human genes:c:coq2|COQ2]]|0.454|
|[[:human genes:n:ndufa8|NDUFA8]]|0.452|
|[[:human genes:m:mrpl44|MRPL44]]|0.452|
|[[:human genes:b:bcs1l|BCS1L]]|0.451|
|[[:human genes:m:mettl1|METTL1]]|0.451|
|[[:human genes:m:mrps2|MRPS2]]|0.451|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.45|
|[[:human genes:e:ecsit|ECSIT]]|0.45|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.45|
|[[:human genes:m:mrpl22|MRPL22]]|0.449|
|[[:human genes:m:mrpl55|MRPL55]]|0.448|
|[[:human genes:m:mrps23|MRPS23]]|0.446|
|[[:human genes:c:cox19|COX19]]|0.446|
|[[:human genes:m:mrps33|MRPS33]]|0.445|
|[[:human genes:m:mrpl39|MRPL39]]|0.444|
|[[:human genes:n:ndufb6|NDUFB6]]|0.443|
|[[:human genes:t:tmem242|TMEM242]]|0.443|
|[[:human genes:t:tfb2m|TFB2M]]|0.442|
|[[:human genes:n:ndufs5|NDUFS5]]|0.442|
|[[:human genes:n:ndufa6|NDUFA6]]|0.44|
|[[:human genes:n:ndufs1|NDUFS1]]|0.439|
|[[:human genes:n:ndufs8|NDUFS8]]|0.436|
|[[:human genes:a:aifm1|AIFM1]]|0.435|
|[[:human genes:m:mrpl11|MRPL11]]|0.434|
|[[:human genes:t:tfam|TFAM]]|0.434|
|[[:human genes:m:mrps9|MRPS9]]|0.432|
|[[:human genes:t:tmem261|TMEM261]]|0.432|
|[[:human genes:h:higd2a|HIGD2A]]|0.431|
|[[:human genes:m:mrpl37|MRPL37]]|0.43|
|[[:human genes:p:ptcd1|PTCD1]]|0.429|
|[[:human genes:n:ndufb10|NDUFB10]]|0.429|
|[[:human genes:a:atp5c1|ATP5C1]]|0.428|
|[[:human genes:g:glrx5|GLRX5]]|0.427|
|[[:human genes:n:ndufc1|NDUFC1]]|0.426|
|[[:human genes:s:sfxn4|SFXN4]]|0.425|
|[[:human genes:p:pde12|PDE12]]|0.425|
|[[:human genes:f:foxred1|FOXRED1]]|0.423|
|[[:human genes:p:prepl|PREPL]]|0.423|
|[[:human genes:n:ndufb2|NDUFB2]]|0.422|
|[[:human genes:m:minos1|MINOS1]]|0.422|
|[[:human genes:t:timm17a|TIMM17A]]|0.421|
|[[:human genes:m:mrpl35|MRPL35]]|0.421|
|[[:human genes:s:sco1|SCO1]]|0.419|
|[[:human genes:n:ndufb7|NDUFB7]]|0.418|
|[[:human genes:m:mrpl28|MRPL28]]|0.418|
|[[:human genes:f:fastkd1|FASTKD1]]|0.416|
|[[:human genes:m:mrps28|MRPS28]]|0.414|
|[[:human genes:t:tufm|TUFM]]|0.414|
|[[:human genes:c:coq4|COQ4]]|0.412|
|[[:human genes:m:mrpl51|MRPL51]]|0.412|
|[[:human genes:n:ndufb5|NDUFB5]]|0.412|
|[[:human genes:m:mrpl48|MRPL48]]|0.412|
|[[:human genes:o:opa1|OPA1]]|0.412|
|[[:human genes:n:ndufa10|NDUFA10]]|0.411|
|[[:human genes:s:slc25a3|SLC25A3]]|0.411|
|[[:human genes:n:ndufb4|NDUFB4]]|0.41|
|[[:human genes:a:aldh18a1|ALDH18A1]]|0.41|
|[[:human genes:d:dnlz|DNLZ]]|0.408|
|[[:human genes:m:mpv17l2|MPV17L2]]|0.408|
|[[:human genes:m:mtpap|MTPAP]]|0.407|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.407|
|[[:human genes:m:mrps18b|MRPS18B]]|0.405|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.405|
|[[:human genes:c:cox7b|COX7B]]|0.404|
|[[:human genes:m:mtif3|MTIF3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 765
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PET112 Expression in NALM6 Cells: 4.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>