======= PET117 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PET117
  * **<color #00a2e8>Official Name</color>**: PET117 cytochrome c oxidase chaperone
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=100303755|100303755]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6UWS5|Q6UWS5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PET117&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PET117|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614771|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial respiratory chain complex IV assembly|
|respiratory chain complex IV assembly|
|cytochrome complex assembly|
|mitochondrial respiratory chain complex assembly|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|mitochondrion|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.8|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|1.84|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.86|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.89|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|1.9|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.92|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.95|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|2.02|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.02|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.07|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.07|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|2.09|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.09|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|2.12|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|2.15|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.17|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.18|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.23|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.25|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.28|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.39|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.51|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.54|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.77|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|2.78|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|3.16|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|3.18|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|3.36|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:coa3|COA3]]|0.724|
|[[:human genes:n:nars2|NARS2]]|0.67|
|[[:human genes:s:selrc1|SELRC1]]|0.668|
|[[:human genes:p:pet112|PET112]]|0.649|
|[[:human genes:m:mettl17|METTL17]]|0.633|
|[[:human genes:l:lars2|LARS2]]|0.627|
|[[:human genes:c:cox11|COX11]]|0.627|
|[[:human genes:q:qrsl1|QRSL1]]|0.622|
|[[:human genes:e:ears2|EARS2]]|0.621|
|[[:human genes:c:coa6|COA6]]|0.621|
|[[:human genes:c:cars2|CARS2]]|0.612|
|[[:human genes:m:malsu1|MALSU1]]|0.607|
|[[:human genes:a:aars2|AARS2]]|0.606|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.602|
|[[:human genes:s:sco2|SCO2]]|0.6|
|[[:human genes:n:ndufa2|NDUFA2]]|0.59|
|[[:human genes:n:ndufb11|NDUFB11]]|0.589|
|[[:human genes:t:tfb1m|TFB1M]]|0.588|
|[[:human genes:m:mrps27|MRPS27]]|0.586|
|[[:human genes:w:wars2|WARS2]]|0.585|
|[[:human genes:d:ddx28|DDX28]]|0.58|
|[[:human genes:a:acad9|ACAD9]]|0.579|
|[[:human genes:m:mrpl45|MRPL45]]|0.576|
|[[:human genes:m:mrps21|MRPS21]]|0.575|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.575|
|[[:human genes:c:cox18|COX18]]|0.574|
|[[:human genes:n:ndufs2|NDUFS2]]|0.567|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.567|
|[[:human genes:d:dap3|DAP3]]|0.566|
|[[:human genes:m:mrpl21|MRPL21]]|0.565|
|[[:human genes:t:tars2|TARS2]]|0.563|
|[[:human genes:m:mrps25|MRPS25]]|0.56|
|[[:human genes:m:mto1|MTO1]]|0.559|
|[[:human genes:f:ftsj2|FTSJ2]]|0.558|
|[[:human genes:p:pars2|PARS2]]|0.557|
|[[:human genes:e:eral1|ERAL1]]|0.556|
|[[:human genes:m:mrps6|MRPS6]]|0.556|
|[[:human genes:m:mrpl47|MRPL47]]|0.554|
|[[:human genes:m:mrps16|MRPS16]]|0.553|
|[[:human genes:m:mrpl49|MRPL49]]|0.553|
|[[:human genes:m:mtif2|MTIF2]]|0.552|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.55|
|[[:human genes:f:fastkd2|FASTKD2]]|0.547|
|[[:human genes:g:grsf1|GRSF1]]|0.546|
|[[:human genes:r:rpusd3|RPUSD3]]|0.545|
|[[:human genes:c:cox15|COX15]]|0.544|
|[[:human genes:m:mrps34|MRPS34]]|0.544|
|[[:human genes:r:rmnd1|RMND1]]|0.543|
|[[:human genes:d:dars2|DARS2]]|0.543|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.542|
|[[:human genes:n:nubpl|NUBPL]]|0.542|
|[[:human genes:p:polg2|POLG2]]|0.542|
|[[:human genes:c:cox20|COX20]]|0.54|
|[[:human genes:r:rars2|RARS2]]|0.539|
|[[:human genes:m:mcat|MCAT]]|0.538|
|[[:human genes:f:fastkd5|FASTKD5]]|0.537|
|[[:human genes:m:mrpl17|MRPL17]]|0.536|
|[[:human genes:p:ptcd3|PTCD3]]|0.531|
|[[:human genes:m:mrps12|MRPS12]]|0.529|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.526|
|[[:human genes:m:mtg1|MTG1]]|0.525|
|[[:human genes:n:ndufa1|NDUFA1]]|0.524|
|[[:human genes:c:chchd1|CHCHD1]]|0.519|
|[[:human genes:p:prepl|PREPL]]|0.518|
|[[:human genes:p:polrmt|POLRMT]]|0.518|
|[[:human genes:c:c1qbp|C1QBP]]|0.517|
|[[:human genes:c:clpp|CLPP]]|0.516|
|[[:human genes:n:ndufa3|NDUFA3]]|0.516|
|[[:human genes:y:yars2|YARS2]]|0.514|
|[[:human genes:r:rbfa|RBFA]]|0.512|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.512|
|[[:human genes:l:lrpprc|LRPPRC]]|0.511|
|[[:human genes:r:rpusd4|RPUSD4]]|0.511|
|[[:human genes:m:mrps26|MRPS26]]|0.51|
|[[:human genes:n:nsun4|NSUN4]]|0.51|
|[[:human genes:m:mrpl3|MRPL3]]|0.51|
|[[:human genes:m:mrps35|MRPS35]]|0.509|
|[[:human genes:g:gfm1|GFM1]]|0.509|
|[[:human genes:m:mtg2|MTG2]]|0.509|
|[[:human genes:n:ndufb10|NDUFB10]]|0.508|
|[[:human genes:g:gfm2|GFM2]]|0.507|
|[[:human genes:c:coq2|COQ2]]|0.507|
|[[:human genes:m:mrps18b|MRPS18B]]|0.506|
|[[:human genes:v:vars2|VARS2]]|0.504|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.504|
|[[:human genes:u:uqcc1|UQCC1]]|0.504|
|[[:human genes:c:cox16|COX16]]|0.502|
|[[:human genes:c:cox6b1|COX6B1]]|0.501|
|[[:human genes:s:sco1|SCO1]]|0.5|
|[[:human genes:m:mpv17l2|MPV17L2]]|0.5|
|[[:human genes:m:mrpl43|MRPL43]]|0.498|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.498|
|[[:human genes:m:mrpl28|MRPL28]]|0.498|
|[[:human genes:c:c12orf65|C12orf65]]|0.497|
|[[:human genes:s:ssbp1|SSBP1]]|0.497|
|[[:human genes:m:mrpl2|MRPL2]]|0.497|
|[[:human genes:m:mrps24|MRPS24]]|0.496|
|[[:human genes:m:mrps5|MRPS5]]|0.496|
|[[:human genes:b:bcs1l|BCS1L]]|0.493|
|[[:human genes:c:cox6a1|COX6A1]]|0.492|
|[[:human genes:m:mrpl4|MRPL4]]|0.491|
|[[:human genes:m:mrp63|MRP63]]|0.49|
|[[:human genes:h:higd2a|HIGD2A]]|0.489|
|[[:human genes:m:mrpl22|MRPL22]]|0.489|
|[[:human genes:m:mrpl23|MRPL23]]|0.487|
|[[:human genes:p:polg|POLG]]|0.487|
|[[:human genes:s:slc31a1|SLC31A1]]|0.486|
|[[:human genes:m:mrpl44|MRPL44]]|0.486|
|[[:human genes:n:ndufs5|NDUFS5]]|0.485|
|[[:human genes:w:wbscr16|WBSCR16]]|0.484|
|[[:human genes:m:mrpl11|MRPL11]]|0.484|
|[[:human genes:n:ndufa8|NDUFA8]]|0.482|
|[[:human genes:m:mrps10|MRPS10]]|0.481|
|[[:human genes:m:mrpl53|MRPL53]]|0.481|
|[[:human genes:n:ndufb2|NDUFB2]]|0.479|
|[[:human genes:a:aifm1|AIFM1]]|0.479|
|[[:human genes:m:mars2|MARS2]]|0.478|
|[[:human genes:c:cox7b|COX7B]]|0.478|
|[[:human genes:m:mrpl1|MRPL1]]|0.477|
|[[:human genes:e:ecsit|ECSIT]]|0.474|
|[[:human genes:n:ndufc1|NDUFC1]]|0.473|
|[[:human genes:n:ndufc2|NDUFC2]]|0.473|
|[[:human genes:f:fars2|FARS2]]|0.472|
|[[:human genes:n:ndufb9|NDUFB9]]|0.47|
|[[:human genes:c:cox19|COX19]]|0.47|
|[[:human genes:m:mrpl18|MRPL18]]|0.47|
|[[:human genes:m:mrpl35|MRPL35]]|0.47|
|[[:human genes:m:mrpl39|MRPL39]]|0.469|
|[[:human genes:n:ndufa11|NDUFA11]]|0.469|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.467|
|[[:human genes:n:ndufv1|NDUFV1]]|0.467|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.467|
|[[:human genes:m:mterfd1|MTERFD1]]|0.465|
|[[:human genes:m:mrpl37|MRPL37]]|0.463|
|[[:human genes:p:pdss2|PDSS2]]|0.461|
|[[:human genes:m:mrpl20|MRPL20]]|0.46|
|[[:human genes:m:mrps22|MRPS22]]|0.459|
|[[:human genes:n:ndufa6|NDUFA6]]|0.457|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.456|
|[[:human genes:p:pde12|PDE12]]|0.455|
|[[:human genes:n:ndufb6|NDUFB6]]|0.454|
|[[:human genes:n:ndufb4|NDUFB4]]|0.454|
|[[:human genes:m:mtif3|MTIF3]]|0.453|
|[[:human genes:h:hars2|HARS2]]|0.453|
|[[:human genes:m:mrps14|MRPS14]]|0.451|
|[[:human genes:n:ndufs8|NDUFS8]]|0.451|
|[[:human genes:c:cluh|CLUH]]|0.449|
|[[:human genes:t:taco1|TACO1]]|0.447|
|[[:human genes:n:ndufv2|NDUFV2]]|0.446|
|[[:human genes:m:mterfd2|MTERFD2]]|0.446|
|[[:human genes:t:trub2|TRUB2]]|0.446|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.444|
|[[:human genes:s:slc25a51|SLC25A51]]|0.444|
|[[:human genes:t:trit1|TRIT1]]|0.444|
|[[:human genes:m:mtrf1|MTRF1]]|0.443|
|[[:human genes:c:cox17|COX17]]|0.443|
|[[:human genes:t:tomm20|TOMM20]]|0.441|
|[[:human genes:m:mrps18a|MRPS18A]]|0.438|
|[[:human genes:s:slc25a3|SLC25A3]]|0.437|
|[[:human genes:y:ybey|YBEY]]|0.437|
|[[:human genes:f:fastkd1|FASTKD1]]|0.436|
|[[:human genes:m:mrrf|MRRF]]|0.435|
|[[:human genes:p:pnpt1|PNPT1]]|0.435|
|[[:human genes:m:mtpap|MTPAP]]|0.434|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.434|
|[[:human genes:m:mrps23|MRPS23]]|0.433|
|[[:human genes:g:gatc|GATC]]|0.429|
|[[:human genes:p:ptcd2|PTCD2]]|0.428|
|[[:human genes:c:coq7|COQ7]]|0.428|
|[[:human genes:m:mrps2|MRPS2]]|0.428|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.426|
|[[:human genes:m:mrpl55|MRPL55]]|0.425|
|[[:human genes:c:c10orf2|C10orf2]]|0.42|
|[[:human genes:m:mipep|MIPEP]]|0.42|
|[[:human genes:t:tmem261|TMEM261]]|0.418|
|[[:human genes:m:mrps9|MRPS9]]|0.418|
|[[:human genes:n:ndufa4|NDUFA4]]|0.417|
|[[:human genes:o:oma1|OMA1]]|0.416|
|[[:human genes:m:mrpl9|MRPL9]]|0.415|
|[[:human genes:t:tsfm|TSFM]]|0.414|
|[[:human genes:s:surf1|SURF1]]|0.414|
|[[:human genes:m:mrpl48|MRPL48]]|0.413|
|[[:human genes:m:mrpl51|MRPL51]]|0.412|
|[[:human genes:n:ndufa10|NDUFA10]]|0.411|
|[[:human genes:m:mrpl33|MRPL33]]|0.411|
|[[:human genes:m:mrps7|MRPS7]]|0.41|
|[[:human genes:t:tomm6|TOMM6]]|0.409|
|[[:human genes:s:slirp|SLIRP]]|0.408|
|[[:human genes:m:mdh2|MDH2]]|0.408|
|[[:human genes:c:cox7c|COX7C]]|0.407|
|[[:human genes:m:mrpl30|MRPL30]]|0.404|
|[[:human genes:c:coq4|COQ4]]|0.404|
|[[:human genes:a:atp5c1|ATP5C1]]|0.403|
|[[:human genes:m:mrpl42|MRPL42]]|0.402|
|[[:human genes:i:iba57|IBA57]]|0.402|
|[[:human genes:p:pet100|PET100]]|0.402|
|[[:human genes:m:mrpl12|MRPL12]]|0.401|
|[[:human genes:n:noa1|NOA1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 68/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|9/28|
|bone|1/26|
|breast|5/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|3/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|2/21|
|liver|2/20|
|lung|4/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|3/24|
|peripheral nervous system|0/16|
|plasma cell|5/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 565
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.0 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PET117 Expression in NALM6 Cells: 3.0'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>