======= PEX2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PEX2
  * **<color #00a2e8>Official Name</color>**: peroxisomal biogenesis factor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5828|5828]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P28328|P28328]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PEX2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PEX2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/170993|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an integral peroxisomal membrane protein required for peroxisome biogenesis. The protein is thought to be involved in peroxisomal matrix protein import. Mutations in this gene result in one form of Zellweger syndrome and infantile Refsum disease. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Somewhat implicated in the biogenesis of peroxisomes.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C3HC4|
|Pex2 Pex12|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Cdc73/Paf1 complex|
|protein import into peroxisome matrix|
|integral component of peroxisomal membrane|
|peroxisomal membrane transport|
|negative regulation of fibroblast proliferation|
|very long-chain fatty acid metabolic process|
|protein transmembrane import into intracellular organelle|
|protein destabilization|
|intracellular protein transmembrane transport|
|fatty acid beta-oxidation|
|peroxisomal membrane|
|protein transmembrane transport|
|establishment of protein localization to peroxisome|
|protein localization to peroxisome|
|protein targeting to peroxisome|
|peroxisomal transport|
|fatty acid oxidation|
|lipid oxidation|
|peroxisome organization|
|regulation of fibroblast proliferation|
|fatty acid catabolic process|
|monocarboxylic acid catabolic process|
|negative regulation of epithelial cell proliferation|
|protein import|
|cellular lipid catabolic process|
|lipid modification|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|regulation of protein stability|
|lipid catabolic process|
|fatty acid metabolic process|
|regulation of epithelial cell proliferation|
|protein targeting|
|establishment of protein localization to organelle|
|small molecule catabolic process|
|monocarboxylic acid metabolic process|
|negative regulation of cell population proliferation|
|protein ubiquitination|
|protein localization to organelle|
|protein modification by small protein conjugation|
|negative regulation of transcription by RNA polymerase II|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxidation-reduction process|
|protein modification by small protein conjugation or removal|
|intracellular protein transport|
|oxoacid metabolic process|
|organic acid metabolic process|
|negative regulation of transcription, DNA-templated|
|lipid metabolic process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|transmembrane transport|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|peptide transport|
|negative regulation of biosynthetic process|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of gene expression|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-1.85|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|1.71|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|1.73|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.75|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|3.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pex1|PEX1]]|0.568|
|[[:human genes:p:pex7|PEX7]]|0.52|
|[[:human genes:p:pex12|PEX12]]|0.513|
|[[:human genes:p:pex6|PEX6]]|0.479|
|[[:human genes:a:agps|AGPS]]|0.477|
|[[:human genes:p:pex13|PEX13]]|0.448|
|[[:human genes:p:pex3|PEX3]]|0.446|
|[[:human genes:l:ldlr|LDLR]]|0.421|
|[[:human genes:p:pex10|PEX10]]|0.411|
|[[:human genes:p:pex26|PEX26]]|0.408|
|[[:human genes:p:pex5|PEX5]]|0.406|
|[[:human genes:p:pex19|PEX19]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7931
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PEX2 Expression in NALM6 Cells: 5.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>