======= PEX26 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PEX26
  * **<color #00a2e8>Official Name</color>**: peroxisomal biogenesis factor 26
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55670|55670]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z412|Q7Z412]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PEX26&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PEX26|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608666|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the peroxin-26 gene family. It is probably required for protein import into peroxisomes. It anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Defects in this gene are the cause of peroxisome biogenesis disorder complementation group 8 (PBD-CG8). PBD refers to a group of peroxisomal disorders arising from a failure of protein import into the peroxisomal membrane or matrix. The PBD group is comprised of four disorders: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Dec 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pex26|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein import into peroxisome membrane|
|protein import into peroxisome matrix|
|integral component of peroxisomal membrane|
|peroxisomal membrane transport|
|protein transmembrane import into intracellular organelle|
|intracellular protein transmembrane transport|
|peroxisomal membrane|
|protein transmembrane transport|
|establishment of protein localization to peroxisome|
|protein targeting to peroxisome|
|protein localization to peroxisome|
|peroxisomal transport|
|peroxisome organization|
|ATPase binding|
|peroxisome|
|protein import|
|protein targeting to membrane|
|protein C-terminus binding|
|establishment of protein localization to membrane|
|protein-containing complex binding|
|protein targeting|
|establishment of protein localization to organelle|
|protein localization to membrane|
|protein localization to organelle|
|intracellular protein transport|
|transmembrane transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-2.17|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.8|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.13|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.62|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pex10|PEX10]]|0.535|
|[[:human genes:p:pex5|PEX5]]|0.528|
|[[:human genes:p:pex12|PEX12]]|0.492|
|[[:human genes:p:pex1|PEX1]]|0.475|
|[[:human genes:p:polr2j3|POLR2J3]]|0.473|
|[[:human genes:p:pex14|PEX14]]|0.438|
|[[:human genes:p:pex6|PEX6]]|0.435|
|[[:human genes:p:pex13|PEX13]]|0.419|
|[[:human genes:p:pex2|PEX2]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2424
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.1 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PEX26 Expression in NALM6 Cells: 7.1'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>