======= PF4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PF4
  * **<color #00a2e8>Official Name</color>**: platelet factor 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5196|5196]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P02776|P02776]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PF4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PF4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/173460|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. [provided by RefSeq, Oct 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. {ECO:0000269|PubMed:7644496}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|host cell cytoplasm|
|CXCR3 chemokine receptor binding|
|negative regulation of megakaryocyte differentiation|
|negative regulation of MHC class II biosynthetic process|
|negative regulation of cytolysis|
|symbiont-containing vacuole membrane|
|killing by host of symbiont cells|
|disruption by host of symbiont cells|
|killing of cells in other organism involved in symbiotic interaction|
|disruption of cells of other organism involved in symbiotic interaction|
|positive regulation of macrophage differentiation|
|regulation of MHC class II biosynthetic process|
|positive regulation of macrophage derived foam cell differentiation|
|regulation of cytolysis|
|regulation of macrophage differentiation|
|defense response to protozoan|
|response to protozoan|
|regulation of macrophage derived foam cell differentiation|
|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|negative regulation of signal transduction in absence of ligand|
|regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|chemokine activity|
|disruption of cells of other organism|
|killing of cells of other organism|
|regulation of megakaryocyte differentiation|
|positive regulation of myeloid leukocyte differentiation|
|antimicrobial humoral immune response mediated by antimicrobial peptide|
|platelet alpha granule lumen|
|modification by host of symbiont morphology or physiology|
|negative regulation of myeloid cell differentiation|
|interaction with symbiont|
|chemokine-mediated signaling pathway|
|neutrophil chemotaxis|
|positive regulation of tumor necrosis factor production|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|granulocyte chemotaxis|
|cell killing|
|cellular response to chemokine|
|response to chemokine|
|positive regulation of myeloid cell differentiation|
|neutrophil migration|
|granulocyte migration|
|negative regulation of extrinsic apoptotic signaling pathway|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|antimicrobial humoral response|
|regulation of myeloid leukocyte differentiation|
|negative regulation of vasculature development|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|myeloid leukocyte migration|
|platelet degranulation|
|negative regulation of hemopoiesis|
|platelet activation|
|leukocyte chemotaxis|
|cAMP-mediated signaling|
|positive regulation of leukocyte differentiation|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|regulation of extrinsic apoptotic signaling pathway|
|modification of morphology or physiology of other organism|
|heparin binding|
|cyclic-nucleotide-mediated signaling|
|cellular response to lipopolysaccharide|
|positive regulation of hemopoiesis|
|cellular response to molecule of bacterial origin|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|cell chemotaxis|
|cellular response to biotic stimulus|
|negative regulation of apoptotic signaling pathway|
|regulation of myeloid cell differentiation|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|regulation of leukocyte differentiation|
|regulation of angiogenesis|
|blood coagulation|
|coagulation|
|hemostasis|
|response to lipopolysaccharide|
|regulation of vasculature development|
|response to molecule of bacterial origin|
|second-messenger-mediated signaling|
|humoral immune response|
|collagen-containing extracellular matrix|
|leukocyte migration|
|regulation of apoptotic signaling pathway|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|wound healing|
|regulation of body fluid levels|
|inflammatory response|
|cellular response to lipid|
|chemotaxis|
|taxis|
|response to wounding|
|cytokine-mediated signaling pathway|
|response to bacterium|
|regulation of cytokine production|
|regulated exocytosis|
|negative regulation of cell differentiation|
|symbiotic process|
|exocytosis|
|interspecies interaction between organisms|
|response to lipid|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|negative regulation of developmental process|
|defense response to other organism|
|cell migration|
|positive regulation of cell differentiation|
|negative regulation of cell death|
|secretion by cell|
|cellular response to cytokine stimulus|
|export from cell|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|cell activation|
|cell motility|
|localization of cell|
|response to cytokine|
|secretion|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of macromolecule biosynthetic process|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp518|RK-33 8μM R08 exp518]]|-1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5186
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PF4 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>