======= PFN2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PFN2
  * **<color #00a2e8>Official Name</color>**: profilin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5217|5217]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35080|P35080]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PFN2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PFN2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176590|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Profilin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of ruffle assembly|
|modification of postsynaptic actin cytoskeleton|
|modification of postsynaptic structure|
|modification of synaptic structure|
|negative regulation of plasma membrane bounded cell projection assembly|
|actin monomer binding|
|regulation of ruffle assembly|
|positive regulation of stress fiber assembly|
|negative regulation of actin filament polymerization|
|positive regulation of ATPase activity|
|positive regulation of actin filament bundle assembly|
|negative regulation of protein polymerization|
|negative regulation of epithelial cell migration|
|phosphatidylinositol-4,5-bisphosphate binding|
|regulation of synaptic vesicle exocytosis|
|regulation of stress fiber assembly|
|regulation of ATPase activity|
|Schaffer collateral - CA1 synapse|
|postsynapse|
|regulation of actomyosin structure organization|
|positive regulation of actin filament polymerization|
|regulation of actin filament bundle assembly|
|presynapse|
|positive regulation of peptidyl-serine phosphorylation|
|regulation of neurotransmitter secretion|
|regulation of synaptic vesicle cycle|
|positive regulation of protein polymerization|
|negative regulation of supramolecular fiber organization|
|negative regulation of protein complex assembly|
|regulation of peptidyl-serine phosphorylation|
|negative regulation of cytoskeleton organization|
|regulation of neurotransmitter transport|
|regulation of regulated secretory pathway|
|regulation of actin filament polymerization|
|protein stabilization|
|negative regulation of cell projection organization|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|positive regulation of supramolecular fiber organization|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|regulation of epithelial cell migration|
|positive regulation of cytoskeleton organization|
|regulation of exocytosis|
|regulation of protein polymerization|
|ATPase activity|
|positive regulation of protein complex assembly|
|negative regulation of cell migration|
|regulation of actin filament organization|
|actin binding|
|synapse organization|
|negative regulation of cell motility|
|regulation of protein stability|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|regulation of actin cytoskeleton organization|
|glutamatergic synapse|
|regulation of supramolecular fiber organization|
|regulation of neurotransmitter levels|
|cytoskeleton|
|negative regulation of organelle organization|
|regulation of cellular component size|
|regulation of actin filament-based process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of protein complex assembly|
|actin cytoskeleton organization|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|regulation of vesicle-mediated transport|
|actin filament-based process|
|positive regulation of organelle organization|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|regulation of secretion by cell|
|positive regulation of hydrolase activity|
|regulation of secretion|
|regulation of cell migration|
|regulation of cell motility|
|regulation of cellular localization|
|regulation of cellular component biogenesis|
|regulation of locomotion|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|cytoskeleton organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|regulation of organelle organization|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-1.83|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-1.81|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|1.71|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|1.74|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.81|
|[[:results:exp148|SB202190 10μM R03 exp148]]|1.92|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.95|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|1.98|
|[[:results:exp136|MS094 2μM R03 exp136]]|2.48|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17448
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PFN2 Expression in NALM6 Cells: -0.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>