======= PGAM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PGAM1
  * **<color #00a2e8>Official Name</color>**: phosphoglycerate mutase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5223|5223]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P18669|P18669]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PGAM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PGAM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/172250|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|His Phos 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of pentose-phosphate shunt|
|phosphoglycerate mutase activity|
|bisphosphoglycerate mutase activity|
|regulation of NADP metabolic process|
|regulation of cellular carbohydrate catabolic process|
|regulation of secondary metabolic process|
|respiratory burst|
|canonical glycolysis|
|glucose catabolic process to pyruvate|
|NADH regeneration|
|glycolytic process through fructose-6-phosphate|
|glycolytic process through glucose-6-phosphate|
|glucose catabolic process|
|NADH metabolic process|
|glycolytic process|
|ATP generation from ADP|
|gluconeogenesis|
|NAD metabolic process|
|hexose biosynthetic process|
|ADP metabolic process|
|hexose catabolic process|
|monosaccharide biosynthetic process|
|nucleoside diphosphate phosphorylation|
|monosaccharide catabolic process|
|purine nucleoside diphosphate metabolic process|
|nucleotide phosphorylation|
|purine ribonucleoside diphosphate metabolic process|
|ribonucleoside diphosphate metabolic process|
|pyruvate metabolic process|
|hydrolase activity|
|regulation of glycolytic process|
|nucleoside diphosphate metabolic process|
|regulation of carbohydrate catabolic process|
|glucose metabolic process|
|secretory granule lumen|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|carbohydrate catabolic process|
|regulation of ATP metabolic process|
|ficolin-1-rich granule lumen|
|carbohydrate biosynthetic process|
|regulation of cellular carbohydrate metabolic process|
|hexose metabolic process|
|regulation of generation of precursor metabolites and energy|
|monosaccharide metabolic process|
|regulation of carbohydrate metabolic process|
|ATP metabolic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|regulation of cellular amide metabolic process|
|generation of precursor metabolites and energy|
|regulation of small molecule metabolic process|
|small molecule catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|protein kinase binding|
|carbohydrate metabolic process|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|monocarboxylic acid metabolic process|
|nucleobase-containing small molecule metabolic process|
|myeloid leukocyte activation|
|small molecule biosynthetic process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|regulation of cellular catabolic process|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|leukocyte activation|
|oxidation-reduction process|
|regulation of catabolic process|
|oxoacid metabolic process|
|secretion by cell|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|phosphorylation|
|regulation of phosphorylation|
|small molecule metabolic process|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 206/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|9/28|
|blood|7/28|
|bone|10/26|
|breast|9/33|
|central nervous system|27/56|
|cervix|0/4|
|colorectal|5/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|2/21|
|liver|7/20|
|lung|16/75|
|lymphocyte|3/16|
|ovary|5/26|
|pancreas|5/24|
|peripheral nervous system|8/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|9/24|
|soft tissue|2/9|
|thyroid|1/2|
|upper aerodigestive|6/22|
|urinary tract|9/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 774
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PGAM1 Expression in NALM6 Cells: 7.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>