======= PGAP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PGAP1
  * **<color #00a2e8>Official Name</color>**: post-GPI attachment to proteins inositol deacylase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80055|80055]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q75T13|Q75T13]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PGAP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PGAP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611655|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene functions early in the glycosylphosphatidylinositol (GPI) biosynthetic pathway, catalyzing the inositol deacylation of GPI. The encoded protein is required for the production of GPI that can attach to proteins, and this may be an important factor in the transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi. Defects in this gene are a cause an autosomal recessive form of cognitive impairment. [provided by RefSeq, Jul 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PGAP1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatidylinositol deacylase activity|
|phosphoric ester hydrolase activity|
|myo-inositol transport|
|attachment of GPI anchor to protein|
|hydrolase activity, acting on ester bonds|
|polyol transport|
|nuclease activity|
|forebrain regionalization|
|GPI anchor biosynthetic process|
|GPI anchor metabolic process|
|anterior/posterior axis specification|
|embryonic pattern specification|
|glycolipid biosynthetic process|
|protein lipidation|
|axis specification|
|lipoprotein biosynthetic process|
|phosphatidylinositol biosynthetic process|
|glycolipid metabolic process|
|liposaccharide metabolic process|
|lipoprotein metabolic process|
|membrane lipid biosynthetic process|
|organic hydroxy compound transport|
|sensory perception of sound|
|sensory perception of mechanical stimulus|
|phosphatidylinositol metabolic process|
|membrane lipid metabolic process|
|glycerophospholipid biosynthetic process|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|anterior/posterior pattern specification|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|nucleic acid phosphodiester bond hydrolysis|
|glycerophospholipid metabolic process|
|regionalization|
|Golgi vesicle transport|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|forebrain development|
|pattern specification process|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|carbohydrate derivative biosynthetic process|
|brain development|
|head development|
|organophosphate metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|sensory perception|
|embryo development|
|central nervous system development|
|endoplasmic reticulum|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|nervous system process|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp239|PFI-2 4μM R05 exp239]]|-1.9|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|-1.89|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10577
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PGAP1 Expression in NALM6 Cells: 4.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>