======= PHAX =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PHAX
  * **<color #00a2e8>Official Name</color>**: phosphorylated adaptor for RNA export
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51808|51808]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H814|Q9H814]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PHAX&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PHAX|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604924|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation- independent manner (By similarity). Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA. {ECO:0000250, ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:15574333}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RNA GG bind|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|snRNA export from nucleus|
|snRNA transport|
|toxic substance binding|
|ncRNA export from nucleus|
|Cajal body|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|ncRNA transcription|
|RNA export from nucleus|
|nuclear export|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|RNA localization|
|nucleobase-containing compound transport|
|nucleocytoplasmic transport|
|nuclear transport|
|neuronal cell body|
|transcription by RNA polymerase II|
|centrosome|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|RNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-2.17|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2.06|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.95|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.94|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-1.81|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-1.71|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|1.81|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|2.2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 183/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|8/28|
|blood|6/28|
|bone|5/26|
|breast|8/33|
|central nervous system|8/56|
|cervix|0/4|
|colorectal|6/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|7/16|
|kidney|5/21|
|liver|6/20|
|lung|25/75|
|lymphocyte|6/16|
|ovary|8/26|
|pancreas|7/24|
|peripheral nervous system|5/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|5/24|
|soft tissue|3/9|
|thyroid|1/2|
|upper aerodigestive|6/22|
|urinary tract|3/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2353
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PHAX Expression in NALM6 Cells: 5.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>