======= PHEX =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PHEX
  * **<color #00a2e8>Official Name</color>**: phosphate regulating endopeptidase homolog X-linked
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5251|5251]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P78562|P78562]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PHEX&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PHEX|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300550|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a transmembrane endopeptidase that belongs to the type II integral membrane zinc-dependent endopeptidase family. The protein is thought to be involved in bone and dentin mineralization and renal phosphate reabsorption. Mutations in this gene cause X-linked hypophosphatemic rickets. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Probably involved in bone and dentin mineralization and renal phosphate reabsorption.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M13 N|
|Peptidase M13|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to insulin-like growth factor stimulus|
|response to sodium phosphate|
|cellular response to parathyroid hormone stimulus|
|response to parathyroid hormone|
|cellular response to vitamin D|
|response to salt|
|cellular response to vitamin|
|response to vitamin D|
|response to growth hormone|
|bone mineralization|
|cellular response to nutrient|
|response to vitamin|
|biomineral tissue development|
|biomineralization|
|metalloendopeptidase activity|
|odontogenesis|
|lung development|
|respiratory tube development|
|respiratory system development|
|bone development|
|response to nutrient|
|cellular response to nutrient levels|
|ossification|
|cellular response to extracellular stimulus|
|cellular response to external stimulus|
|response to peptide hormone|
|response to peptide|
|skeletal system development|
|response to nutrient levels|
|cellular response to lipid|
|response to extracellular stimulus|
|response to inorganic substance|
|cellular response to organic cyclic compound|
|cellular response to hormone stimulus|
|perinuclear region of cytoplasm|
|zinc ion binding|
|tube development|
|response to lipid|
|organophosphate metabolic process|
|response to hormone|
|response to organic cyclic compound|
|animal organ morphogenesis|
|Golgi apparatus|
|response to organonitrogen compound|
|endoplasmic reticulum|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|cell-cell signaling|
|cellular response to endogenous stimulus|
|proteolysis|
|integral component of plasma membrane|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.413|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13673
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PHEX Expression in NALM6 Cells: 0.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>