======= PHF23 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PHF23
  * **<color #00a2e8>Official Name</color>**: PHD finger protein 23
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79142|79142]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BUL5|Q9BUL5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PHF23&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PHF23|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612910|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria. {ECO:0000269|PubMed:25484098}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PHD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of autophagosome maturation|
|regulation of autophagosome maturation|
|negative regulation of autophagosome assembly|
|mitotic chromosome condensation|
|negative regulation of macroautophagy|
|regulation of autophagosome assembly|
|negative regulation of organelle assembly|
|regulation of vacuole organization|
|chromosome condensation|
|negative regulation of protein complex disassembly|
|negative regulation of autophagy|
|mitotic sister chromatid segregation|
|regulation of protein complex disassembly|
|positive regulation of protein ubiquitination|
|positive regulation of protein modification by small protein conjugation or removal|
|sister chromatid segregation|
|mitotic nuclear division|
|regulation of macroautophagy|
|DNA packaging|
|regulation of protein ubiquitination|
|nuclear chromosome segregation|
|regulation of organelle assembly|
|regulation of protein modification by small protein conjugation or removal|
|negative regulation of cellular catabolic process|
|autophagy|
|process utilizing autophagic mechanism|
|chromosome segregation|
|nuclear division|
|DNA conformation change|
|negative regulation of catabolic process|
|organelle fission|
|regulation of autophagy|
|negative regulation of organelle organization|
|chromatin binding|
|mitotic cell cycle process|
|mitotic cell cycle|
|negative regulation of cellular component organization|
|regulation of cellular catabolic process|
|regulation of cellular component biogenesis|
|regulation of catabolic process|
|cell cycle process|
|chromosome organization|
|positive regulation of protein modification process|
|regulation of organelle organization|
|cell cycle|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|cellular catabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.73|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|1.87|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|2.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1556
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PHF23 Expression in NALM6 Cells: 5.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>