======= PHIP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PHIP
  * **<color #00a2e8>Official Name</color>**: pleckstrin homology domain interacting protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55023|55023]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WWQ0|Q8WWQ0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PHIP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PHIP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612870|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that binds to the insulin receptor substrate 1 protein and regulates glucose transporter translocation in skeletal muscle cells. The encoded protein may also regulate growth and survival of pancreatic beta cells. Elevated copy number of this gene may be associated with melanoma severity and the encoded protein may promote melanoma metastasis in human patients. [provided by RefSeq, Oct 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
|Bromodomain|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of insulin-like growth factor receptor signaling pathway|
|lysine-acetylated histone binding|
|insulin receptor binding|
|regulation of insulin-like growth factor receptor signaling pathway|
|positive regulation of mitotic nuclear division|
|positive regulation of nuclear division|
|insulin receptor signaling pathway|
|negative regulation of extrinsic apoptotic signaling pathway|
|positive regulation of mitotic cell cycle|
|regulation of cell shape|
|regulation of extrinsic apoptotic signaling pathway|
|cellular response to insulin stimulus|
|regulation of mitotic nuclear division|
|regulation of nuclear division|
|negative regulation of apoptotic signaling pathway|
|response to insulin|
|cellular response to peptide hormone stimulus|
|positive regulation of cell cycle process|
|cellular response to peptide|
|positive regulation of cell cycle|
|response to peptide hormone|
|regulation of apoptotic signaling pathway|
|response to peptide|
|regulation of cell morphogenesis|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|cellular response to nitrogen compound|
|enzyme linked receptor protein signaling pathway|
|regulation of cell cycle process|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|positive regulation of cell population proliferation|
|negative regulation of cell death|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|response to nitrogen compound|
|cytoskeleton organization|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of RNA metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-2.39|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-2.27|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-2.2|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-2.09|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-2.09|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.89|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-1.87|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.83|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-1.83|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-1.81|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.79|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-1.78|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-1.74|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.73|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.75|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.82|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|1.84|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.87|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|1.97|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.99|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|2.01|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|2.11|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.16|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|2.19|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|2.23|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.29|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|2.34|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.48|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.68|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|3.05|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|3.55|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:phf6|PHF6]]|0.559|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10706
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PHIP Expression in NALM6 Cells: 7.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>