======= PHKG2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PHKG2
  * **<color #00a2e8>Official Name</color>**: phosphorylase kinase catalytic subunit gamma 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5261|5261]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15735|P15735]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PHKG2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PHKG2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/172471|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by this gene. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9C, also known as autosomal liver glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (By similarity). {ECO:0000250, ECO:0000269|PubMed:10487978}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of glycogen catabolic process|
|phosphorylase kinase activity|
|phosphorylase kinase complex|
|regulation of glycogen catabolic process|
|regulation of cellular carbohydrate catabolic process|
|glycogen catabolic process|
|glucan catabolic process|
|positive regulation of glycogen metabolic process|
|glycogen biosynthetic process|
|glucan biosynthetic process|
|cellular polysaccharide catabolic process|
|tau-protein kinase activity|
|polysaccharide catabolic process|
|calmodulin-dependent protein kinase activity|
|regulation of glycogen metabolic process|
|positive regulation of glucose metabolic process|
|cellular carbohydrate catabolic process|
|regulation of polysaccharide metabolic process|
|polysaccharide biosynthetic process|
|cellular polysaccharide biosynthetic process|
|glycogen metabolic process|
|cellular glucan metabolic process|
|glucan metabolic process|
|positive regulation of cellular carbohydrate metabolic process|
|cellular carbohydrate biosynthetic process|
|energy reserve metabolic process|
|cellular polysaccharide metabolic process|
|positive regulation of carbohydrate metabolic process|
|polysaccharide metabolic process|
|regulation of carbohydrate catabolic process|
|regulation of glucose metabolic process|
|carbohydrate catabolic process|
|carbohydrate biosynthetic process|
|positive regulation of small molecule metabolic process|
|regulation of cellular carbohydrate metabolic process|
|regulation of generation of precursor metabolites and energy|
|cellular carbohydrate metabolic process|
|calmodulin binding|
|regulation of carbohydrate metabolic process|
|energy derivation by oxidation of organic compounds|
|enzyme binding|
|protein serine/threonine kinase activity|
|positive regulation of cellular catabolic process|
|generation of precursor metabolites and energy|
|regulation of small molecule metabolic process|
|positive regulation of catabolic process|
|carbohydrate metabolic process|
|regulation of cellular catabolic process|
|oxidation-reduction process|
|protein phosphorylation|
|regulation of catabolic process|
|macromolecule catabolic process|
|phosphorylation|
|ATP binding|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10535
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PHKG2 Expression in NALM6 Cells: 5.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>