======= PHLDB2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PHLDB2
  * **<color #00a2e8>Official Name</color>**: pleckstrin homology like domain family B member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=90102|90102]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86SQ0|Q86SQ0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PHLDB2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PHLDB2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610298|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of wound healing, spreading of epidermal cells|
|regulation of basement membrane assembly involved in embryonic body morphogenesis|
|regulation of basement membrane organization|
|basal cortex|
|positive regulation of basement membrane assembly involved in embryonic body morphogenesis|
|regulation of wound healing, spreading of epidermal cells|
|negative regulation of morphogenesis of an epithelium|
|negative regulation of focal adhesion assembly|
|negative regulation of adherens junction organization|
|negative regulation of stress fiber assembly|
|positive regulation of extracellular matrix organization|
|negative regulation of cell junction assembly|
|negative regulation of actin filament bundle assembly|
|positive regulation of embryonic development|
|regulation of gastrulation|
|negative regulation of cell-matrix adhesion|
|regulation of extracellular matrix organization|
|cell leading edge|
|intermediate filament cytoskeleton|
|regulation of cell-substrate junction assembly|
|regulation of focal adhesion assembly|
|negative regulation of cell-substrate adhesion|
|regulation of adherens junction organization|
|negative regulation of wound healing|
|regulation of stress fiber assembly|
|regulation of epithelial to mesenchymal transition|
|negative regulation of response to wounding|
|regulation of cell junction assembly|
|regulation of actomyosin structure organization|
|regulation of actin filament bundle assembly|
|regulation of cell-matrix adhesion|
|regulation of embryonic development|
|negative regulation of supramolecular fiber organization|
|regulation of wound healing|
|negative regulation of cytoskeleton organization|
|regulation of response to wounding|
|regulation of morphogenesis of an epithelium|
|regulation of microtubule cytoskeleton organization|
|regulation of cell-substrate adhesion|
|regulation of microtubule-based process|
|negative regulation of cell migration|
|regulation of actin filament organization|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|negative regulation of cellular component movement|
|cadherin binding|
|negative regulation of locomotion|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|negative regulation of response to external stimulus|
|negative regulation of organelle organization|
|regulation of actin filament-based process|
|focal adhesion|
|microtubule cytoskeleton organization|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|microtubule-based process|
|regulation of cell adhesion|
|negative regulation of cellular component organization|
|regulation of cell migration|
|regulation of cell motility|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|cytoskeleton organization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|positive regulation of developmental process|
|regulation of response to stress|
|establishment of protein localization|
|negative regulation of response to stimulus|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5514
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PHLDB2 Expression in NALM6 Cells: 5.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>