======= PHOX2B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PHOX2B
  * **<color #00a2e8>Official Name</color>**: paired like homeobox 2B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8929|8929]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99453|Q99453]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PHOX2B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PHOX2B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603851|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum- response element.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|efferent axon development in a lateral line nerve|
|retrotrapezoid nucleus neuron differentiation|
|retrotrapezoid nucleus development|
|medullary reticular formation development|
|lateral line nerve development|
|lateral line system development|
|medulla oblongata development|
|noradrenergic neuron development|
|hindbrain tangential cell migration|
|neural crest cell migration involved in autonomic nervous system development|
|brainstem development|
|noradrenergic neuron differentiation|
|sympathetic ganglion development|
|enteric nervous system development|
|regulation of respiratory gaseous exchange by nervous system process|
|cell migration in hindbrain|
|regulation of respiratory system process|
|ganglion development|
|cell differentiation in hindbrain|
|parasympathetic nervous system development|
|sympathetic nervous system development|
|regulation of respiratory gaseous exchange|
|negative regulation of cell cycle arrest|
|positive regulation of G2/M transition of mitotic cell cycle|
|positive regulation of cell cycle G2/M phase transition|
|dopaminergic neuron differentiation|
|central nervous system neuron axonogenesis|
|autonomic nervous system development|
|skeletal muscle cell differentiation|
|cranial nerve development|
|neural crest cell migration|
|neural nucleus development|
|positive regulation of mitotic cell cycle phase transition|
|nerve development|
|neural crest cell development|
|central nervous system neuron development|
|mesenchymal cell development|
|stem cell development|
|neural crest cell differentiation|
|positive regulation of cell cycle phase transition|
|positive regulation of cold-induced thermogenesis|
|cellular response to BMP stimulus|
|response to BMP|
|regulation of cell cycle arrest|
|neuron migration|
|skeletal muscle tissue development|
|skeletal muscle organ development|
|regulation of cold-induced thermogenesis|
|positive regulation of mitotic cell cycle|
|hindbrain development|
|mesenchymal cell differentiation|
|stem cell differentiation|
|glial cell differentiation|
|ameboidal-type cell migration|
|central nervous system neuron differentiation|
|inner ear development|
|regulation of G2/M transition of mitotic cell cycle|
|respiratory system development|
|regulation of cell cycle G2/M phase transition|
|gliogenesis|
|mesenchyme development|
|ear development|
|negative regulation of neuron differentiation|
|nuclear chromatin|
|striated muscle tissue development|
|positive regulation of cell cycle process|
|negative regulation of neurogenesis|
|muscle organ development|
|muscle tissue development|
|negative regulation of nervous system development|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|negative regulation of cell cycle process|
|negative regulation of cell development|
|positive regulation of neuron differentiation|
|sensory system development|
|axonogenesis|
|positive regulation of cell cycle|
|axon development|
|regulation of mitotic cell cycle phase transition|
|cell morphogenesis involved in neuron differentiation|
|regulation of cell cycle phase transition|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|positive regulation of neurogenesis|
|muscle structure development|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cellular response to growth factor stimulus|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|cell part morphogenesis|
|response to growth factor|
|positive regulation of nervous system development|
|positive regulation of cell development|
|sensory organ development|
|cell morphogenesis involved in differentiation|
|negative regulation of cell cycle|
|regulation of system process|
|regulation of mitotic cell cycle|
|regulation of neuron differentiation|
|neuron projection development|
|negative regulation of cell population proliferation|
|negative regulation of cell differentiation|
|cell morphogenesis|
|brain development|
|regulation of cell cycle process|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|cell migration|
|positive regulation of cell differentiation|
|central nervous system development|
|neuron differentiation|
|cell motility|
|localization of cell|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|locomotion|
|positive regulation of developmental process|
|nervous system process|
|response to endogenous stimulus|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12891
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PHOX2B Expression in NALM6 Cells: -2.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>