======= PHPT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PHPT1
  * **<color #00a2e8>Official Name</color>**: phosphohistidine phosphatase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29085|29085]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NRX4|Q9NRX4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PHPT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PHPT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610167|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Exhibits phosphohistidine phosphatase activity. {ECO:0000269|PubMed:19836471, ECO:0000269|PubMed:25574816}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ocnus|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of ATP citrate synthase activity|
|peptidyl-histidine dephosphorylation|
|regulation of ATP citrate synthase activity|
|protein histidine phosphatase activity|
|calcium channel inhibitor activity|
|negative regulation of T cell receptor signaling pathway|
|negative regulation of lyase activity|
|negative regulation of antigen receptor-mediated signaling pathway|
|positive regulation of insulin secretion involved in cellular response to glucose stimulus|
|regulation of actin cytoskeleton reorganization|
|regulation of T cell receptor signaling pathway|
|regulation of lyase activity|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|regulation of antigen receptor-mediated signaling pathway|
|positive regulation of insulin secretion|
|positive regulation of peptide hormone secretion|
|ion channel binding|
|positive regulation of hormone secretion|
|regulation of insulin secretion|
|regulation of peptide hormone secretion|
|protein dephosphorylation|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|negative regulation of transferase activity|
|positive regulation of peptide secretion|
|dephosphorylation|
|regulation of actin cytoskeleton organization|
|regulation of actin filament-based process|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of secretion|
|negative regulation of immune system process|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of peptide secretion|
|positive regulation of cell motility|
|regulation of hormone levels|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of locomotion|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|negative regulation of catalytic activity|
|regulation of secretion|
|regulation of cell motility|
|regulation of cellular localization|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|regulation of protein localization|
|negative regulation of molecular function|
|regulation of immune response|
|negative regulation of signal transduction|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of response to stimulus|
|regulation of immune system process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-2.4|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|-2.01|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.99|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|-1.95|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-1.86|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-1.71|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14725
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PHPT1 Expression in NALM6 Cells: 4.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>