======= PICK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PICK1
  * **<color #00a2e8>Official Name</color>**: protein interacting with PRKCA 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9463|9463]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NRD5|Q9NRD5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PICK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PICK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605926|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function. {ECO:0000269|PubMed:20403402}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PDZ|
|Arfaptin|
|BAR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|postsynaptic early endosome|
|negative regulation of Arp2/3 complex-mediated actin nucleation|
|changes to DNA methylation involved in embryo development|
|DNA methylation involved in embryo development|
|Arp2/3 complex binding|
|negative regulation of actin nucleation|
|dendritic spine maintenance|
|neuronal ion channel clustering|
|regulation of Arp2/3 complex-mediated actin nucleation|
|long-term synaptic depression|
|DNA methylation involved in gamete generation|
|monoamine transport|
|positive regulation of receptor internalization|
|regulation of actin nucleation|
|protein kinase C-activating G protein-coupled receptor signaling pathway|
|dendritic spine organization|
|neuron maturation|
|neuron projection organization|
|cellular response to glucose starvation|
|aggresome|
|cellular component maintenance|
|receptor clustering|
|DNA methylation|
|DNA alkylation|
|positive regulation of receptor-mediated endocytosis|
|protein kinase C binding|
|regulation of receptor internalization|
|negative regulation of synaptic transmission|
|DNA methylation or demethylation|
|G protein-coupled receptor binding|
|endocytic vesicle membrane|
|presynaptic membrane|
|localization within membrane|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|postsynapse organization|
|DNA modification|
|trans-Golgi network membrane|
|positive regulation of endocytosis|
|regulation of receptor-mediated endocytosis|
|phospholipid binding|
|glial cell development|
|synaptic vesicle|
|negative regulation of supramolecular fiber organization|
|anatomical structure maturation|
|negative regulation of cytoskeleton organization|
|cellular response to starvation|
|cell maturation|
|regulation of actin filament polymerization|
|glial cell differentiation|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|protein C-terminus binding|
|regulation of synaptic plasticity|
|response to starvation|
|cellular response to decreased oxygen levels|
|postsynaptic membrane|
|actin filament binding|
|regulation of endocytosis|
|gliogenesis|
|cellular response to oxygen levels|
|regulation of protein polymerization|
|cellular response to nutrient levels|
|developmental maturation|
|protein domain specific binding|
|macromolecule methylation|
|postsynaptic density|
|regulation of actin filament organization|
|cellular response to extracellular stimulus|
|synapse|
|synapse organization|
|methylation|
|neuron projection|
|cellular response to external stimulus|
|signaling receptor binding|
|regulation of actin cytoskeleton organization|
|enzyme binding|
|regulation of supramolecular fiber organization|
|cellular process involved in reproduction in multicellular organism|
|response to decreased oxygen levels|
|cytoskeleton|
|Golgi vesicle transport|
|negative regulation of organelle organization|
|regulation of cellular component size|
|response to oxygen levels|
|regulation of actin filament-based process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of protein complex assembly|
|protein localization to membrane|
|response to nutrient levels|
|regulation of anatomical structure size|
|response to extracellular stimulus|
|regulation of cytoskeleton organization|
|cell junction|
|regulation of vesicle-mediated transport|
|gamete generation|
|perinuclear region of cytoplasm|
|negative regulation of cellular component organization|
|DNA metabolic process|
|neuron development|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|membrane organization|
|regulation of cellular component biogenesis|
|protein phosphorylation|
|embryo development|
|Golgi apparatus|
|positive regulation of transport|
|multi-organism reproductive process|
|intracellular protein transport|
|neuron differentiation|
|identical protein binding|
|plasma membrane bounded cell projection organization|
|response to abiotic stimulus|
|cell projection organization|
|positive regulation of cellular component organization|
|mitochondrion|
|phosphorylation|
|regulation of organelle organization|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|reproductive process|
|reproduction|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|cell development|
|cellular response to stress|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.7|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|1.77|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.77|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|1.77|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16506
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PICK1 Expression in NALM6 Cells: 1.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>