======= PID1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PID1
  * **<color #00a2e8>Official Name</color>**: phosphotyrosine interaction domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55022|55022]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z2X4|Q7Z2X4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PID1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PID1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612930|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Increases proliferation of preadipocytes without affecting adipocytic differentiation. {ECO:0000269|PubMed:16815647}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PID|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of ATP biosynthetic process|
|positive regulation of fat cell proliferation|
|negative regulation of purine nucleotide biosynthetic process|
|negative regulation of nucleotide biosynthetic process|
|regulation of mitochondrial fusion|
|regulation of fat cell proliferation|
|positive regulation of ATP biosynthetic process|
|negative regulation of glucose import|
|negative regulation of glucose transmembrane transport|
|cellular response to leptin stimulus|
|negative regulation of purine nucleotide metabolic process|
|regulation of ATP biosynthetic process|
|negative regulation of nucleotide metabolic process|
|mitochondrion morphogenesis|
|positive regulation of nucleotide biosynthetic process|
|negative regulation of protein localization to plasma membrane|
|positive regulation of purine nucleotide biosynthetic process|
|response to leptin|
|negative regulation of protein localization to cell periphery|
|negative regulation of ATP metabolic process|
|negative regulation of protein localization to membrane|
|cellular response to interleukin-6|
|negative regulation of insulin receptor signaling pathway|
|negative regulation of cellular response to insulin stimulus|
|response to interleukin-6|
|regulation of purine nucleotide biosynthetic process|
|regulation of nucleotide biosynthetic process|
|positive regulation of ATP metabolic process|
|positive regulation of purine nucleotide metabolic process|
|positive regulation of nucleotide metabolic process|
|cellular response to fatty acid|
|regulation of glucose import|
|energy reserve metabolic process|
|regulation of insulin receptor signaling pathway|
|regulation of mitochondrial membrane potential|
|regulation of cellular response to insulin stimulus|
|regulation of glucose transmembrane transport|
|response to fatty acid|
|negative regulation of small molecule metabolic process|
|regulation of protein localization to plasma membrane|
|positive regulation of reactive oxygen species metabolic process|
|fat cell differentiation|
|negative regulation of cellular protein localization|
|regulation of protein localization to cell periphery|
|negative regulation of transmembrane transport|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|positive regulation of small molecule metabolic process|
|regulation of reactive oxygen species metabolic process|
|regulation of mitochondrion organization|
|regulation of protein localization to membrane|
|cellular response to acid chemical|
|energy derivation by oxidation of organic compounds|
|cellular response to tumor necrosis factor|
|response to tumor necrosis factor|
|response to acid chemical|
|negative regulation of protein phosphorylation|
|generation of precursor metabolites and energy|
|regulation of small molecule metabolic process|
|regulation of membrane potential|
|mitochondrion organization|
|negative regulation of phosphorylation|
|negative regulation of transport|
|cell part morphogenesis|
|cellular response to lipid|
|regulation of cellular protein localization|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of transmembrane transport|
|negative regulation of protein modification process|
|cellular response to hormone stimulus|
|cellular component morphogenesis|
|response to lipid|
|response to hormone|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|oxidation-reduction process|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|response to cytokine|
|negative regulation of protein metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-1.78|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.76|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18097
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PID1 Expression in NALM6 Cells: -1.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>