======= PIH1D1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PIH1D1
  * **<color #00a2e8>Official Name</color>**: PIH1 domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55011|55011]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NWS0|Q9NWS0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PIH1D1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PIH1D1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611480|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (PubMed:17636026). Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription (PubMed:22368283, PubMed:24036451). Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (PubMed:20864032). Positively regulates the assembly and activity of the mTORC1 complex (PubMed:24036451). {ECO:0000269|PubMed:17636026, ECO:0000269|PubMed:20864032, ECO:0000269|PubMed:22368283, ECO:0000269|PubMed:24036451}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PIH1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase I upstream control element sequence-specific DNA binding|
|negative regulation of histone H3-K9 dimethylation|
|positive regulation of glucose mediated signaling pathway|
|regulation of TORC2 signaling|
|negative regulation of histone H4-K16 acetylation|
|regulation of histone H3-K9 dimethylation|
|regulation of glucose mediated signaling pathway|
|R2TP complex|
|negative regulation of histone H3-K9 trimethylation|
|negative regulation of histone H4 acetylation|
|snoRNA localization|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|
|regulation of histone H4-K16 acetylation|
|pre-snoRNP complex|
|positive regulation of histone H4 acetylation|
|establishment of protein localization to chromatin|
|positive regulation of histone H3-K9 acetylation|
|RNA polymerase I CORE element sequence-specific DNA binding|
|RNA polymerase I preinitiation complex assembly|
|box C/D snoRNP assembly|
|positive regulation of transcription of nucleolar large rRNA by RNA polymerase I|
|small nucleolar ribonucleoprotein complex assembly|
|regulation of histone H3-K9 trimethylation|
|negative regulation of histone H3-K9 methylation|
|regulation of histone H4 acetylation|
|regulation of transcription of nucleolar large rRNA by RNA polymerase I|
|regulation of histone H3-K9 acetylation|
|negative regulation of histone acetylation|
|establishment of protein localization to chromosome|
|positive regulation of TORC1 signaling|
|regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|
|negative regulation of peptidyl-lysine acetylation|
|negative regulation of histone methylation|
|negative regulation of protein acetylation|
|positive regulation of transcription by RNA polymerase I|
|regulation of histone H3-K9 methylation|
|protein localization to chromatin|
|regulation of histone H3-K4 methylation|
|transcription preinitiation complex assembly|
|positive regulation of histone acetylation|
|regulation of transcription by RNA polymerase I|
|positive regulation of peptidyl-lysine acetylation|
|phosphoprotein binding|
|transcription initiation from RNA polymerase I promoter|
|positive regulation of TOR signaling|
|transcription by RNA polymerase I|
|regulation of TORC1 signaling|
|positive regulation of protein acetylation|
|negative regulation of histone modification|
|regulation of histone acetylation|
|negative regulation of chromatin organization|
|regulation of peptidyl-lysine acetylation|
|protein localization to chromosome|
|regulation of histone methylation|
|regulation of protein acetylation|
|ATPase binding|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of cysteine-type endopeptidase activity|
|positive regulation of histone modification|
|regulation of TOR signaling|
|positive regulation of chromatin organization|
|histone binding|
|negative regulation of chromosome organization|
|regulation of histone modification|
|chromatin remodeling|
|positive regulation of chromosome organization|
|regulation of chromatin organization|
|protein-DNA complex assembly|
|rRNA processing|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|DNA-templated transcription, initiation|
|RNA localization|
|rRNA metabolic process|
|negative regulation of apoptotic signaling pathway|
|ribonucleoprotein complex assembly|
|regulation of cysteine-type endopeptidase activity|
|protein-DNA complex subunit organization|
|negative regulation of endopeptidase activity|
|ribonucleoprotein complex subunit organization|
|positive regulation of protein complex assembly|
|negative regulation of peptidase activity|
|ribosome biogenesis|
|positive regulation of protein serine/threonine kinase activity|
|regulation of chromosome organization|
|negative regulation of proteolysis|
|negative regulation of organelle organization|
|ncRNA processing|
|regulation of apoptotic signaling pathway|
|regulation of endopeptidase activity|
|establishment of protein localization to organelle|
|regulation of peptidase activity|
|regulation of protein complex assembly|
|negative regulation of hydrolase activity|
|ribonucleoprotein complex biogenesis|
|protein kinase binding|
|ncRNA metabolic process|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cellular component biogenesis|
|positive regulation of protein kinase activity|
|positive regulation of kinase activity|
|negative regulation of protein modification process|
|positive regulation of organelle organization|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|positive regulation of transferase activity|
|epithelial cell differentiation|
|chromatin organization|
|negative regulation of cellular component organization|
|regulation of proteolysis|
|protein localization to organelle|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|cellular protein-containing complex assembly|
|nucleolus|
|regulation of kinase activity|
|RNA processing|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cellular component biogenesis|
|regulation of transferase activity|
|negative regulation of cell death|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|negative regulation of protein metabolic process|
|epithelium development|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|RNA metabolic process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.7|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.71|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|1.79|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|1.79|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.82|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.83|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.89|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.93|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|2.11|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.11|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.31|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.35|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.75|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.8|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.83|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.84|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|3.32|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|3.51|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nfrkb|NFRKB]]|0.538|
|[[:human genes:u:uchl5|UCHL5]]|0.46|
|[[:human genes:r:rrm1|RRM1]]|0.456|
|[[:human genes:i:ino80c|INO80C]]|0.439|
|[[:human genes:a:actr5|ACTR5]]|0.429|
|[[:human genes:t:tfpt|TFPT]]|0.426|
|[[:human genes:z:zbtb17|ZBTB17]]|0.414|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4422
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PIH1D1 Expression in NALM6 Cells: 6.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>