======= PIK3CD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PIK3CD
  * **<color #00a2e8>Official Name</color>**: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5293|5293]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00329|O00329]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PIK3CD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PIK3CD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602839|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Phosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Have a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Have important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for its biological function. Isoform 2 may be involved in stabilizing total RAS levels, resulting in increased ERK phosphorylation and increased PI3K activity. {ECO:0000269|PubMed:20081091, ECO:0000269|PubMed:22020336}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PI3Ka|
|PI3K rbd|
|PI3K p85B|
|PI3 PI4 kinase|
|PI3K C2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|natural killer cell chemotaxis|
|mast cell differentiation|
|positive regulation of neutrophil apoptotic process|
|phosphatidylinositol-3,4-bisphosphate 5-kinase activity|
|phosphatidylinositol 3-kinase activity|
|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|
|mast cell chemotaxis|
|mast cell migration|
|B cell chemotaxis|
|neutrophil extravasation|
|respiratory burst involved in defense response|
|1-phosphatidylinositol-4-phosphate 3-kinase activity|
|regulation of neutrophil apoptotic process|
|positive regulation of myeloid cell apoptotic process|
|natural killer cell differentiation|
|1-phosphatidylinositol-3-kinase activity|
|T cell chemotaxis|
|phosphatidylinositol-3-phosphate biosynthetic process|
|mast cell degranulation|
|mast cell activation involved in immune response|
|mast cell mediated immunity|
|respiratory burst|
|phosphatidylinositol 3-kinase complex|
|mast cell granule|
|mast cell activation|
|T cell migration|
|positive regulation of leukocyte apoptotic process|
|regulation of myeloid cell apoptotic process|
|phosphatidylinositol 3-kinase signaling|
|cellular extravasation|
|lysosome localization|
|lymphocyte chemotaxis|
|phosphatidylinositol phosphorylation|
|natural killer cell activation|
|lipid phosphorylation|
|lymphocyte migration|
|phosphatidylinositol-mediated signaling|
|inositol lipid-mediated signaling|
|kinase activity|
|regulation of leukocyte apoptotic process|
|neutrophil chemotaxis|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|granulocyte chemotaxis|
|neutrophil migration|
|granulocyte migration|
|phosphatidylinositol biosynthetic process|
|myeloid leukocyte differentiation|
|regulation of phosphatidylinositol 3-kinase signaling|
|B cell receptor signaling pathway|
|myeloid leukocyte migration|
|T cell differentiation|
|leukocyte chemotaxis|
|cytokine production|
|B cell activation|
|positive regulation of protein kinase B signaling|
|phosphatidylinositol metabolic process|
|T cell receptor signaling pathway|
|lipid modification|
|glycerophospholipid biosynthetic process|
|cell chemotaxis|
|myeloid cell differentiation|
|regulation of protein kinase B signaling|
|glycerolipid biosynthetic process|
|T cell activation|
|lymphocyte differentiation|
|phospholipid biosynthetic process|
|axon guidance|
|neuron projection guidance|
|antigen receptor-mediated signaling pathway|
|glycerophospholipid metabolic process|
|leukocyte differentiation|
|establishment of organelle localization|
|axonogenesis|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|leukocyte migration|
|lymphocyte activation|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|immune response-activating cell surface receptor signaling pathway|
|neuron projection morphogenesis|
|immune response-regulating cell surface receptor signaling pathway|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|inflammatory response|
|positive regulation of cell migration|
|leukocyte degranulation|
|cell part morphogenesis|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|positive regulation of cell motility|
|organophosphate biosynthetic process|
|positive regulation of cellular component movement|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|cell morphogenesis involved in differentiation|
|hemopoiesis|
|immune response-activating signal transduction|
|lipid biosynthetic process|
|organelle localization|
|myeloid leukocyte activation|
|immune response-regulating signaling pathway|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|immune system development|
|neuron projection development|
|cytokine-mediated signaling pathway|
|positive regulation of cell death|
|regulated exocytosis|
|cell morphogenesis|
|leukocyte mediated immunity|
|innate immune response|
|exocytosis|
|neuron development|
|cellular component morphogenesis|
|regulation of cell migration|
|positive regulation of immune response|
|organophosphate metabolic process|
|regulation of cell motility|
|leukocyte activation|
|defense response to other organism|
|cellular lipid metabolic process|
|cell migration|
|protein phosphorylation|
|regulation of locomotion|
|regulation of cellular component movement|
|secretion by cell|
|cellular response to cytokine stimulus|
|neuron differentiation|
|positive regulation of intracellular signal transduction|
|export from cell|
|cell activation|
|localization of cell|
|cell motility|
|immune effector process|
|response to cytokine|
|secretion|
|plasma membrane bounded cell projection organization|
|positive regulation of immune system process|
|regulation of immune response|
|cell projection organization|
|lipid metabolic process|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|ATP binding|
|intracellular transport|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|neurogenesis|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|negative regulation of gene expression|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|immune response|
|vesicle-mediated transport|
|positive regulation of gene expression|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-2.23|
|[[:results:exp114|A-196 10μM R03 exp114]]|-2.04|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2.04|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-1.78|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-1.77|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.76|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|-1.74|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.7|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.71|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.71|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.75|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|1.76|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.79|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.79|
|[[:results:exp453|B02 10μM R08 exp453]]|1.83|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.88|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.88|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.88|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.92|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.93|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.95|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|2.17|
|[[:results:exp292|Menadione 5μM R06 exp292]]|2.18|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.2|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|2.24|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.29|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.3|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|2.34|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.37|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.4|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|2.43|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.51|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.51|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.53|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.61|
|[[:results:exp275|Citral 75μM R06 exp275]]|2.71|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.75|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|2.78|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.82|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.86|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.88|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|3.07|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|3.22|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|3.42|
|[[:results:exp116|AICAR 240μM R03 exp116]]|3.83|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|4.09|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|4.16|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|4.25|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|4.27|
|[[:results:exp134|MS023 2μM R03 exp134]]|4.31|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|4.39|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|4.57|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rhoh|RHOH]]|0.78|
|[[:human genes:c:cd19|CD19]]|0.761|
|[[:human genes:m:mapkap1|MAPKAP1]]|0.747|
|[[:human genes:s:syk|SYK]]|0.746|
|[[:human genes:c:cd81|CD81]]|0.712|
|[[:human genes:r:rictor|RICTOR]]|0.702|
|[[:human genes:a:akt2|AKT2]]|0.675|
|[[:human genes:i:igll1|IGLL1]]|0.667|
|[[:human genes:e:ergic1|ERGIC1]]|0.593|
|[[:human genes:p:pdpk1|PDPK1]]|0.566|
|[[:human genes:c:cd79b|CD79B]]|0.565|
|[[:human genes:m:mlst8|MLST8]]|0.539|
|[[:human genes:c:cd79a|CD79A]]|0.533|
|[[:human genes:a:akt1|AKT1]]|0.471|
|[[:human genes:b:bcl2l11|BCL2L11]]|0.467|
|[[:human genes:v:vezf1|VEZF1]]|0.463|
|[[:human genes:d:dph5|DPH5]]|0.456|
|[[:human genes:p:pik3r1|PIK3R1]]|0.437|
|[[:human genes:m:mmd|MMD]]|0.433|
|[[:human genes:g:gnas|GNAS]]|0.425|
|[[:human genes:d:dph1|DPH1]]|0.423|
|[[:human genes:s:ssr2|SSR2]]|0.417|
|[[:human genes:p:pds5a|PDS5A]]|0.409|
|[[:human genes:g:ganab|GANAB]]|0.405|
|[[:human genes:t:tox4|TOX4]]|0.402|
|[[:human genes:m:mocs3|MOCS3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4286
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PIK3CD Expression in NALM6 Cells: 7.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>