======= PIK3R2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PIK3R2
  * **<color #00a2e8>Official Name</color>**: phosphoinositide-3-kinase regulatory subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5296|5296]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00459|O00459]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PIK3R2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PIK3R2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603157|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5- trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin- dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity). {ECO:0000250|UniProtKB:O08908, ECO:0000269|PubMed:23604317}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RhoGAP|
|SH2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|1-phosphatidylinositol-3-kinase regulator activity|
|phosphatidylinositol 3-kinase complex|
|phosphatidylinositol 3-kinase signaling|
|positive regulation of protein import into nucleus|
|positive regulation of protein import|
|phosphotyrosine residue binding|
|phosphatidylinositol phosphorylation|
|regulation of phosphatidylinositol 3-kinase activity|
|regulation of protein import into nucleus|
|receptor tyrosine kinase binding|
|regulation of protein import|
|regulation of lipid kinase activity|
|positive regulation of nucleocytoplasmic transport|
|lipid phosphorylation|
|vascular endothelial growth factor receptor signaling pathway|
|phosphatidylinositol-mediated signaling|
|inositol lipid-mediated signaling|
|positive regulation of protein localization to nucleus|
|regulation of phospholipid metabolic process|
|protein phosphatase binding|
|cellular glucose homeostasis|
|insulin receptor signaling pathway|
|regulation of nucleocytoplasmic transport|
|phosphatidylinositol biosynthetic process|
|regulation of protein localization to nucleus|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|Fc receptor mediated stimulatory signaling pathway|
|Fc-gamma receptor signaling pathway|
|positive regulation of intracellular protein transport|
|cellular response to insulin stimulus|
|positive regulation of protein kinase B signaling|
|negative regulation of MAPK cascade|
|phosphatidylinositol metabolic process|
|Fc-epsilon receptor signaling pathway|
|T cell receptor signaling pathway|
|glucose homeostasis|
|carbohydrate homeostasis|
|lipid modification|
|glycerophospholipid biosynthetic process|
|positive regulation of intracellular transport|
|regulation of protein kinase B signaling|
|glycerolipid biosynthetic process|
|response to insulin|
|regulation of intracellular protein transport|
|Fc receptor signaling pathway|
|phospholipid biosynthetic process|
|response to endoplasmic reticulum stress|
|cellular response to peptide hormone stimulus|
|antigen receptor-mediated signaling pathway|
|glycerophospholipid metabolic process|
|positive regulation of cellular protein localization|
|cellular response to peptide|
|phagocytosis|
|regulation of autophagy|
|regulation of small GTPase mediated signal transduction|
|regulation of intracellular transport|
|phospholipid metabolic process|
|leukocyte migration|
|glycerolipid metabolic process|
|response to peptide hormone|
|regulation of lipid metabolic process|
|negative regulation of protein phosphorylation|
|positive regulation of protein transport|
|negative regulation of phosphorylation|
|immune response-activating cell surface receptor signaling pathway|
|positive regulation of establishment of protein localization|
|response to peptide|
|immune response-regulating cell surface receptor signaling pathway|
|protein heterodimerization activity|
|negative regulation of intracellular signal transduction|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|organophosphate biosynthetic process|
|regulation of cellular protein localization|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|immune response-activating signal transduction|
|lipid biosynthetic process|
|negative regulation of protein modification process|
|immune response-regulating signaling pathway|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|activation of immune response|
|cellular response to nitrogen compound|
|regulation of protein transport|
|enzyme linked receptor protein signaling pathway|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of MAPK cascade|
|regulation of cellular catabolic process|
|positive regulation of immune response|
|regulation of kinase activity|
|organophosphate metabolic process|
|cellular homeostasis|
|response to hormone|
|regulation of cellular localization|
|cellular lipid metabolic process|
|cell migration|
|regulation of transferase activity|
|positive regulation of transport|
|regulation of catabolic process|
|response to organonitrogen compound|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|immune effector process|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|positive regulation of immune system process|
|regulation of immune response|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|phosphorylation|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|protein transport|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|amide transport|
|regulation of phosphorylation|
|establishment of protein localization|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|nitrogen compound transport|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|1.73|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|1.78|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|1.85|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5082
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PIK3R2 Expression in NALM6 Cells: 6.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>