======= PINK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PINK1
  * **<color #00a2e8>Official Name</color>**: PTEN induced kinase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=65018|65018]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BXM7|Q9BXM7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PINK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PINK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608309|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcium-dependent protein kinase activity|
|regulation of free ubiquitin chain polymerization|
|positive regulation of free ubiquitin chain polymerization|
|negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway|
|regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway|
|positive regulation of cristae formation|
|cellular response to hydrogen sulfide|
|regulation of cristae formation|
|TORC2 complex binding|
|negative regulation of mitochondrial fission|
|negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide|
|response to hydrogen sulfide|
|mitochondrion to lysosome transport|
|mitochondrion-derived vesicle mediated transport|
|regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide|
|positive regulation of mitochondrial electron transport, NADH to ubiquinone|
|regulation of mitochondrial electron transport, NADH to ubiquinone|
|regulation of hypoxia-induced intrinsic apoptotic signaling pathway|
|maintenance of protein location in mitochondrion|
|negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway|
|negative regulation of hydrogen peroxide-mediated programmed cell death|
|Lewy body|
|positive regulation of mitochondrial ATP synthesis coupled electron transport|
|negative regulation of hydrogen peroxide-induced neuron death|
|negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway|
|regulation of hydrogen peroxide-induced neuron death|
|positive regulation of NMDA glutamate receptor activity|
|C3HC4-type RING finger domain binding|
|TORC2 signaling|
|positive regulation of histone deacetylase activity|
|positive regulation of dopamine secretion|
|positive regulation of synaptic transmission, dopaminergic|
|astrocyte projection|
|negative regulation of cellular response to hypoxia|
|regulation of mitochondrial ATP synthesis coupled electron transport|
|regulation of synaptic vesicle transport|
|positive regulation of deacetylase activity|
|positive regulation of mitophagy in response to mitochondrial depolarization|
|peptidyl-serine autophosphorylation|
|regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway|
|positive regulation of mitophagy|
|negative regulation of autophagy of mitochondrion|
|regulation of histone deacetylase activity|
|regulation of hydrogen peroxide-mediated programmed cell death|
|positive regulation of cellular respiration|
|positive regulation of oxidative phosphorylation|
|peptidase activator activity|
|protein kinase B binding|
|regulation of deacetylase activity|
|positive regulation of ATP biosynthetic process|
|positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization|
|regulation of autophagy of mitochondrion in response to mitochondrial depolarization|
|negative regulation of autophagosome assembly|
|regulation of cellular response to hypoxia|
|positive regulation of catecholamine secretion|
|positive regulation of mitochondrial fission|
|positive regulation of glutamate receptor signaling pathway|
|negative regulation of response to reactive oxygen species|
|regulation of synaptic transmission, dopaminergic|
|negative regulation of hydrogen peroxide-induced cell death|
|regulation of mitophagy|
|positive regulation of histone deacetylation|
|regulation of ATP biosynthetic process|
|positive regulation of autophagy of mitochondrion|
|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|response to mitochondrial depolarisation|
|negative regulation of oxidative stress-induced neuron death|
|negative regulation of cellular response to drug|
|integral component of mitochondrial outer membrane|
|regulation of hydrogen peroxide metabolic process|
|positive regulation of protein deacetylation|
|regulation of hydrogen peroxide-induced cell death|
|positive regulation of nucleotide biosynthetic process|
|positive regulation of purine nucleotide biosynthetic process|
|regulation of mitochondrial fission|
|regulation of oxidative stress-induced neuron death|
|regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|negative regulation of response to drug|
|TOR signaling|
|regulation of histone deacetylation|
|regulation of oxidative phosphorylation|
|positive regulation of release of cytochrome c from mitochondria|
|regulation of cellular respiration|
|positive regulation of response to drug|
|positive regulation of protein targeting to mitochondrion|
|positive regulation of ubiquitin-protein transferase activity|
|activation of protein kinase B activity|
|negative regulation of macroautophagy|
|regulation of response to reactive oxygen species|
|positive regulation of signaling receptor activity|
|positive regulation of amine transport|
|regulation of autophagosome assembly|
|regulation of cellular response to drug|
|negative regulation of JNK cascade|
|regulation of NMDA receptor activity|
|regulation of cofactor metabolic process|
|negative regulation of organelle assembly|
|autophagy of mitochondrion|
|maintenance of protein localization in organelle|
|mitochondrion disassembly|
|regulation of purine nucleotide biosynthetic process|
|regulation of nucleotide biosynthetic process|
|regulation of dopamine secretion|
|regulation of vacuole organization|
|regulation of autophagy of mitochondrion|
|regulation of protein deacetylation|
|regulation of protein targeting to mitochondrion|
|positive regulation of protein dephosphorylation|
|negative regulation of stress-activated protein kinase signaling cascade|
|negative regulation of cellular response to oxidative stress|
|negative regulation of oxidative stress-induced cell death|
|positive regulation of purine nucleotide metabolic process|
|positive regulation of nucleotide metabolic process|
|positive regulation of ATP metabolic process|
|negative regulation of stress-activated MAPK cascade|
|negative regulation of response to oxidative stress|
|regulation of release of cytochrome c from mitochondria|
|response to ischemia|
|regulation of ubiquitin-protein transferase activity|
|negative regulation of mitochondrion organization|
|negative regulation of reactive oxygen species metabolic process|
|positive regulation of dephosphorylation|
|positive regulation of establishment of protein localization to mitochondrion|
|regulation of catecholamine secretion|
|regulation of oxidative stress-induced cell death|
|organelle disassembly|
|regulation of glutamate receptor signaling pathway|
|positive regulation of macroautophagy|
|positive regulation of cation channel activity|
|regulation of mitochondrial membrane potential|
|establishment of protein localization to mitochondrion|
|regulation of establishment of protein localization to mitochondrion|
|cell body|
|regulation of cellular response to oxidative stress|
|maintenance of protein location in cell|
|regulation of neurotransmitter receptor activity|
|mitochondrial intermembrane space|
|protein localization to mitochondrion|
|kinase activity|
|regulation of protein targeting|
|negative regulation of autophagy|
|regulation of response to oxidative stress|
|positive regulation of histone modification|
|regulation of amine transport|
|maintenance of location in cell|
|negative regulation of intrinsic apoptotic signaling pathway|
|regulation of response to drug|
|protease binding|
|positive regulation of ion transmembrane transporter activity|
|positive regulation of chromatin organization|
|positive regulation of peptidyl-serine phosphorylation|
|lysosomal transport|
|maintenance of protein location|
|respiratory electron transport chain|
|positive regulation of transporter activity|
|chromatin|
|positive regulation of protein ubiquitination|
|positive regulation of mitochondrion organization|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|positive regulation of autophagy|
|regulation of ATP metabolic process|
|positive regulation of translation|
|positive regulation of protein polymerization|
|growth cone|
|positive regulation of protein modification by small protein conjugation or removal|
|regulation of peptidyl-serine phosphorylation|
|positive regulation of small molecule metabolic process|
|regulation of protein dephosphorylation|
|vacuolar transport|
|positive regulation of cation transmembrane transport|
|negative regulation of neuron apoptotic process|
|regulation of histone modification|
|positive regulation of cellular amide metabolic process|
|positive regulation of synaptic transmission|
|positive regulation of intracellular protein transport|
|positive regulation of ion transmembrane transport|
|regulation of generation of precursor metabolites and energy|
|regulation of intrinsic apoptotic signaling pathway|
|macroautophagy|
|mitochondrial outer membrane|
|maintenance of location|
|positive regulation of protein kinase B signaling|
|negative regulation of MAPK cascade|
|cellular respiration|
|regulation of cation channel activity|
|regulation of macroautophagy|
|regulation of signaling receptor activity|
|peptidyl-serine phosphorylation|
|positive regulation of chromosome organization|
|positive regulation of apoptotic signaling pathway|
|protein stabilization|
|regulation of reactive oxygen species metabolic process|
|regulation of mitochondrion organization|
|electron transport chain|
|regulation of proteasomal protein catabolic process|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of JNK cascade|
|cellular response to hypoxia|
|regulation of chromatin organization|
|positive regulation of peptidase activity|
|protein autophosphorylation|
|cellular response to decreased oxygen levels|
|peptidyl-serine modification|
|regulation of protein ubiquitination|
|positive regulation of transmembrane transport|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|positive regulation of intracellular transport|
|cellular response to acid chemical|
|regulation of dephosphorylation|
|cellular response to toxic substance|
|magnesium ion binding|
|cellular response to oxygen levels|
|mitochondrial transport|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of protein kinase B signaling|
|regulation of organelle assembly|
|regulation of protein polymerization|
|negative regulation of apoptotic signaling pathway|
|regulation of protein modification by small protein conjugation or removal|
|regulation of intracellular protein transport|
|regulation of stress-activated MAPK cascade|
|energy derivation by oxidation of organic compounds|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of stress-activated protein kinase signaling cascade|
|protein kinase activity|
|cellular response to oxidative stress|
|positive regulation of protein complex assembly|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|regulation of ion transmembrane transporter activity|
|process utilizing autophagic mechanism|
|autophagy|
|positive regulation of DNA-binding transcription factor activity|
|regulation of transmembrane transporter activity|
|protein-containing complex binding|
|positive regulation of ion transport|
|regulation of transporter activity|
|regulation of protein stability|
|ubiquitin protein ligase binding|
|axon|
|negative regulation of catabolic process|
|regulation of neuron death|
|positive regulation of cellular protein localization|
|activation of protein kinase activity|
|regulation of autophagy|
|regulation of cation transmembrane transport|
|response to hypoxia|
|response to acid chemical|
|regulation of chromosome organization|
|regulation of intracellular transport|
|regulation of translation|
|response to decreased oxygen levels|
|positive regulation of proteolysis|
|protein serine/threonine kinase activity|
|positive regulation of cellular catabolic process|
|cytoskeleton|
|negative regulation of organelle organization|
|response to oxygen levels|
|regulation of protein catabolic process|
|response to oxidative stress|
|mitochondrial inner membrane|
|regulation of apoptotic signaling pathway|
|cellular component disassembly|
|positive regulation of secretion by cell|
|regulation of cellular amide metabolic process|
|cellular response to drug|
|negative regulation of protein phosphorylation|
|generation of precursor metabolites and energy|
|positive regulation of protein transport|
|regulation of DNA-binding transcription factor activity|
|regulation of small molecule metabolic process|
|regulation of membrane potential|
|establishment of protein localization to organelle|
|positive regulation of catabolic process|
|positive regulation of secretion|
|mitochondrion organization|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of peptidase activity|
|negative regulation of phosphorylation|
|regulation of protein complex assembly|
|positive regulation of establishment of protein localization|
|regulation of ion transmembrane transport|
|negative regulation of intracellular signal transduction|
|response to toxic substance|
|positive regulation of cellular component biogenesis|
|posttranscriptional regulation of gene expression|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|positive regulation of protein kinase activity|
|response to inorganic substance|
|regulation of cellular protein localization|
|modification-dependent macromolecule catabolic process|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of transmembrane transport|
|positive regulation of kinase activity|
|proteolysis involved in cellular protein catabolic process|
|negative regulation of protein modification process|
|cellular protein catabolic process|
|positive regulation of organelle organization|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of transferase activity|
|protein catabolic process|
|protein ubiquitination|
|perinuclear region of cytoplasm|
|positive regulation of cell death|
|regulation of ion transport|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of proteolysis|
|regulation of cellular response to stress|
|protein localization to organelle|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|protein modification by small protein conjugation|
|regulation of protein kinase activity|
|regulation of secretion|
|regulation of cellular catabolic process|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|cellular macromolecule catabolic process|
|regulation of cellular localization|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|oxidation-reduction process|
|protein phosphorylation|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|regulation of catabolic process|
|negative regulation of cell death|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|organonitrogen compound catabolic process|
|negative regulation of protein metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|mitochondrion|
|negative regulation of signal transduction|
|proteolysis|
|regulation of hydrolase activity|
|phosphorylation|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|ATP binding|
|regulation of apoptotic process|
|regulation of programmed cell death|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11784
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PINK1 Expression in NALM6 Cells: 4.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>