======= PIP5K1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PIP5K1A
  * **<color #00a2e8>Official Name</color>**: phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8394|8394]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99755|Q99755]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PIP5K1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PIP5K1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603275|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during calcium-induced keratinocyte differentiation. Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, diacylglycerol and inositol 1,4,5-trisphosphate that mobilize internal calcium and drive keratinocyte differentiation. Together with PIP5K1C have a role during embryogenesis. Functions also in the nucleus where acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs. {ECO:0000269|PubMed:18288197, ECO:0000269|PubMed:19158393, ECO:0000269|PubMed:20660631}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PIP5K|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|1-phosphatidylinositol-4-phosphate 5-kinase activity|
|fibroblast migration|
|ruffle assembly|
|mRNA cleavage and polyadenylation specificity factor complex|
|ruffle organization|
|cell-substrate adherens junction assembly|
|focal adhesion assembly|
|adherens junction assembly|
|cell-substrate junction assembly|
|phosphatidylinositol phosphorylation|
|lipid phosphorylation|
|actin cytoskeleton reorganization|
|adherens junction organization|
|kinase binding|
|ruffle membrane|
|activation of GTPase activity|
|phosphatidylinositol biosynthetic process|
|regulation of phosphatidylinositol 3-kinase signaling|
|cell-matrix adhesion|
|phosphatidylinositol metabolic process|
|cell junction assembly|
|ameboidal-type cell migration|
|lamellipodium|
|protein localization to plasma membrane|
|cell-substrate adhesion|
|lipid modification|
|glycerophospholipid biosynthetic process|
|cell chemotaxis|
|cell junction organization|
|glycerolipid biosynthetic process|
|protein localization to cell periphery|
|phospholipid biosynthetic process|
|keratinocyte differentiation|
|glycerophospholipid metabolic process|
|epidermal cell differentiation|
|phagocytosis|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|skin development|
|nuclear speck|
|positive regulation of GTPase activity|
|epidermis development|
|focal adhesion|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|protein localization to membrane|
|regulation of GTPase activity|
|actin cytoskeleton organization|
|organophosphate biosynthetic process|
|chemotaxis|
|taxis|
|actin filament-based process|
|lipid biosynthetic process|
|epithelial cell differentiation|
|positive regulation of hydrolase activity|
|organophosphate metabolic process|
|cell adhesion|
|biological adhesion|
|cellular lipid metabolic process|
|cell migration|
|cell motility|
|localization of cell|
|cytoskeleton organization|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|lipid metabolic process|
|regulation of hydrolase activity|
|phosphorylation|
|locomotion|
|positive regulation of catalytic activity|
|ATP binding|
|movement of cell or subcellular component|
|cellular protein localization|
|cellular macromolecule localization|
|tissue development|
|positive regulation of molecular function|
|regulation of intracellular signal transduction|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.473|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.424|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2787
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PIP5K1A Expression in NALM6 Cells: 6.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>