======= PITPNB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PITPNB
  * **<color #00a2e8>Official Name</color>**: phosphatidylinositol transfer protein beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23760|23760]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P48739|P48739]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PITPNB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PITPNB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606876|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IP trans|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatidylcholine transporter activity|
|phosphatidylinositol transfer activity|
|phosphatidylcholine binding|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|phosphatidylinositol binding|
|phospholipid transport|
|organophosphate ester transport|
|nucleus organization|
|lipid transport|
|lipid localization|
|Golgi vesicle transport|
|organic anion transport|
|anion transport|
|Golgi membrane|
|endoplasmic reticulum membrane|
|lipid metabolic process|
|ion transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-4.67|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-3.06|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.87|
|[[:results:exp131|L-74142 5μM R03 exp131]]|-2.12|
|[[:results:exp495|IWR1 50μM R08 exp495]]|-2.04|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.85|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-1.84|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.77|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.81|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|2.26|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|4.38|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|6.63|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rab11a|RAB11A]]|0.48|
|[[:human genes:t:trappc10|TRAPPC10]]|0.433|
|[[:human genes:t:trappc9|TRAPPC9]]|0.426|
|[[:human genes:t:tm9sf2|TM9SF2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18880
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PITPNB Expression in NALM6 Cells: 6.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>