======= PITX2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PITX2
  * **<color #00a2e8>Official Name</color>**: paired like homeodomain 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5308|5308]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99697|Q99697]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PITX2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PITX2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601542|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
|OAR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|prolactin secreting cell differentiation|
|cell proliferation involved in outflow tract morphogenesis|
|cell proliferation involved in heart morphogenesis|
|deltoid tuberosity development|
|cardiac neural crest cell migration involved in outflow tract morphogenesis|
|somatotropin secreting cell differentiation|
|cardiac neural crest cell development involved in outflow tract morphogenesis|
|cardiac neural crest cell differentiation involved in heart development|
|cardiac neural crest cell development involved in heart development|
|iris morphogenesis|
|adenohypophysis development|
|left/right axis specification|
|cell migration involved in heart development|
|left/right pattern formation|
|spleen development|
|hair cell differentiation|
|pituitary gland development|
|RNA polymerase II activating transcription factor binding|
|neural crest cell migration|
|RNA polymerase II transcription factor binding|
|outflow tract morphogenesis|
|transcription regulatory region sequence-specific DNA binding|
|diencephalon development|
|neural crest cell development|
|stem cell development|
|mesenchymal cell development|
|axis specification|
|neural crest cell differentiation|
|camera-type eye morphogenesis|
|cardiocyte differentiation|
|determination of left/right symmetry|
|odontogenesis|
|endocrine system development|
|determination of bilateral symmetry|
|specification of symmetry|
|eye morphogenesis|
|mesenchymal cell differentiation|
|stem cell differentiation|
|ameboidal-type cell migration|
|limb development|
|appendage development|
|bone development|
|transcription factor complex|
|mesenchyme development|
|heart morphogenesis|
|sensory organ morphogenesis|
|camera-type eye development|
|epidermal cell differentiation|
|transcription factor binding|
|regionalization|
|eye development|
|visual system development|
|sensory system development|
|forebrain development|
|gland development|
|epidermis development|
|sequence-specific DNA binding|
|pattern specification process|
|skeletal system development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|heart development|
|sensory organ development|
|cell population proliferation|
|hematopoietic or lymphoid organ development|
|immune system development|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|brain development|
|head development|
|circulatory system development|
|animal organ morphogenesis|
|cell migration|
|central nervous system development|
|neuron differentiation|
|cell motility|
|localization of cell|
|epithelium development|
|positive regulation of transcription by RNA polymerase II|
|locomotion|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-1.74|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|1.83|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.91|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|1.99|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2.26|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17249
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.38 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PITX2 Expression in NALM6 Cells: -2.38'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>