======= PIWIL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PIWIL1
  * **<color #00a2e8>Official Name</color>**: piwi like RNA-mediated gene silencing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9271|9271]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96J94|Q96J94]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PIWIL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PIWIL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605571|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Endoribonuclease that plays a central role in postnatal germ cells by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Strongly prefers a uridine in the first position of their guide (g1U preference, also named 1U-bias). Not involved in the piRNA amplification loop, also named ping-pong amplification cycle. Acts as an endoribonuclease that cleaves transposon messenger RNAs. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability. Required to sequester RNF8 in the cytoplasm until late spermatogenesis; RNF8 being released upon ubiquitination and degradation of PIWIL1. {ECO:0000250|UniProtKB:Q9JMB7}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Piwi|
|GAGE|
|PAZ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mRNA cap binding complex binding|
|piRNA binding|
|dense body|
|polysome binding|
|spermatogenesis, exchange of chromosomal proteins|
|sperm chromatin condensation|
|chromatoid body|
|P granule|
|piRNA metabolic process|
|spermatid nucleus differentiation|
|regulation of transposition|
|negative regulation of transposition|
|endoribonuclease activity|
|histone exchange|
|single-stranded RNA binding|
|ATP-dependent chromatin remodeling|
|RNA phosphodiester bond hydrolysis, endonucleolytic|
|gene silencing by RNA|
|nucleus organization|
|spermatid development|
|gene silencing|
|spermatid differentiation|
|nucleosome organization|
|RNA phosphodiester bond hydrolysis|
|mRNA binding|
|chromatin remodeling|
|DNA packaging|
|meiotic cell cycle|
|protein-DNA complex subunit organization|
|germ cell development|
|DNA conformation change|
|nucleic acid phosphodiester bond hydrolysis|
|regulation of translation|
|cellular process involved in reproduction in multicellular organism|
|regulation of cellular amide metabolic process|
|protein kinase binding|
|ncRNA metabolic process|
|posttranscriptional regulation of gene expression|
|spermatogenesis|
|male gamete generation|
|developmental process involved in reproduction|
|gamete generation|
|chromatin organization|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|multi-organism reproductive process|
|chromosome organization|
|cell cycle|
|reproductive process|
|reproduction|
|cell development|
|RNA metabolic process|
|negative regulation of gene expression|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:l:lig1|LIG1]]|0.416|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9089
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.94 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PIWIL1 Expression in NALM6 Cells: 1.94'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>